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Antidepressants and the Body

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Antidepressants and the Body

Many people in America take millions of pills, syrups and potions and ingest it in some form or another on a daily basis. It is helpful to know exactly what happens inside our bodies when we take some form of medication. Medicines work in a variety of ways depending on what they are taken for and in what form. Medication has a route and form in which they are taken. Medications can be taken in oral which would be a pill or liquid, sublingual in tablet or drops, topically in cream or ointment, inhalation, drops etc. The type of medication and the route will have an effect on where the drug will enter the body and what areas the drug will focus on. In this paper I will explain how antidepressants work with chemicals in the body and also the good and bad of taking antidepressants. About 20 million people in the United States suffer from some form of depression (Schimelpfening, 2012). Depression occurs in someone when endogenous chemicals in the brain are used by the central nervous system to help communicate signals from one area to another. This imbalance in neurotransmitters, such as Serotonin, Dopamine and Norepinephrine plays a role in clinical depression. Decreased production of these neurotransmitters, a lack of receptor sites able to receive these neurotransmitters, and the inability of these neurotransmitters to reach a receptor site plays in an important factor in depression. The most common and effective drug used for people with depression are Tricyclic antidepressants. This medication works by increasing the release of norepinephrine. According to National Science Digital Library, the action of the Tricyclic drugs depends on the central ring of the atoms which looks like the shape of a twist. The side chain must have at least 2 carbons. The amine group is either tertiary or secondary. The goal of tricyclic antidepressants is to block the re-uptake of norepinephrine at nerve terminals. The potency and selectivity for the inhibition of the uptake of norepinephrine, serotonin, and dopamine vary greatly among the different chemicals. The tertiary amine tricyclic take over the serotonin uptake pump, whereas the secondary amine is better at switching off the NE pump. For instance, imipramine is a potent and selective blocker of serotonin transport, while desipramine inhibits the uptake of norepinephrine (Whitten, 2010). Research published in "Geriatrics" in 2008 reports that 25 percent of prescription drugs in the United States are used by the elderly, often for anxiety, and that the prevalence for abuse is approximately 11 percent among females who are depressed. The research also reported that use of benzodiazepines may have caused physical dependence, but tolerance and dose escalation were less common in the older patient (Culberson, 2008). Prescription drug abuse seems to be a continuous and trending issue in the US. This may be because so many Americans are prescribed antidepressants. If America remains in the same state such as poor economy, people without insurance and less access to healthcare; this number is doomed to increase. Many people cannot function through their normal routines of daily living because of depression. Their only hope would be therapy and of course the antidepressants. These drugs may be effective, but like all medications there are side effects. The side-effects can include blurred vision, weight gain or loss, headaches, sedation and many others. If and at all if; an individual will get the side-effects totally depends on the person. Some people may think that taking the antidepressants actually cause physical brain damage. The medication works and adjusts the brain chemistry not the physical parts of the brain. I work as a medication aide at an Alzheimer’s care facility. Dealing with Alzheimer’s patients can have some very stressful moments. As a caregiver you must have skills and lots of patience. Alzheimer’s disease is irreversible and progressive. Many people over the age of 65 may start to show symptoms of the disease, this memory loss and poor judgment are not a normal part of aging. The way the disease slowly kills the brain is it causes plaques and tangles in the brain. These are two of the main features of Alzheimer’s disease. The third is the loss of connections between nerve cells (neurons) in the brain. According to a study done by the National Academy of Science, patients who have had brain scans that have taken antidepressants during adulthood reveal fewer clumps of protein amyloid-beta, a target of Alzheimer’s prevention strategies, when compared with people who have not taken the drugs(6). The absence of Serotonin, Dopamine and Norepinephrine in the brain causes room for the body to have a malfunctioning system. To fix this imbalance doctors rely on these magic pills we call antidepressants. Either way people perceive them as good or bad; I think the good outweigh the bad. People with this type of disorder are able to function and lead a fulfilling life.

References
1. Schimelpfening,Nancy.”How Antidepressants Work”.About.com.October,17,2012.November21,2012.”http://depression.about.com/cs/brainchem101/a/howadswork.htm”
2. Culberson, JW.”Geriatrics-Prescription Drug Misuse”.Geriatrics.com.September08,2008.November 22,2012. “<Geriatrics"; Prescription Drug Misuse/Abuse in Elderly; Culberson, J.W.; Sep 1 2008>".
3. Whitten,Kenneth.”Chemical Education Digital Library”.ChemED DL. 2010.November 26,2012.”http://www.chemeddl.org/alfresco/service/org/chemeddl/nsdl/groups?id=chemeddl_5149&guest=true”
4. Sanders,Laura.”Antidepressants show signs of countering Alzheimers”.Science News.com.August 22,2011.November 28,2012. “http://www.sciencenews.org/view/generic/id/333548/title/Antidepressants_show_signs_of_countering_Alzheimer%E2%80%99s”.

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