Skeletal muscle is one of the three major muscle types (besides cardiac and smooth muscle). They are a form of striated muscle tissue that is controlled by the somatic nervous system. Muscle fibers make up the individual components and are formed from the fusion of myoblast (the cells). Myofibers are multinucleated cells made up from the thin filaments called actin and thick filaments myosin myofibrils (long protein bundles) which are repeated as sarcomere, which act as the machinery for muscle contraction and gives it the striated appearance. Cardiac Muscle Smooth Muscle Skeletal Muscle
The eukaryotic cell is composed of a numerous membrane bound organelles which work together to make a cell function based on the proteins expressed. These cellular components make the endomembrane system. Some of its major components are the Golgi apparatus which functions by modifying proteins and lipids. The cytoplasm is the fluid portion containing the organelles and the cytosol containing the cytoskeleton of the cell. The nuclei contain the genetic material, and functions by controlling gene expression and replicating and transcribing DNA. The endoplasmic reticulum is made up of the rough ER and the smooth ER and has several functions such as facilitates protein folding, protein transport, insertion of proteins, secretion of proteins, and calcium sequestration in the smooth ER.

Calcium is the main regulation and signaling molecule in muscles. The sarcoplasmic reticulum, an internal membrane of the smooth endoplasmic reticulum, which stores and acts as a source for calcium during muscle contraction and sink during muscle relaxation. Assembly of the sarcoplasmic reticulum is determined by calcium concentrations and distribution. (Jorgensen 1977) The skeletal muscle cells are responsible for voluntary