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Bystander Effect Essay

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Theoretically when cells are irradiated with ionizing radiation, the biological effects of this is expected in the cell population that received the radiation and not the in the cells that haven’t received any radiation. However, this was disproved by the occurrence of radiation induced bystander effect.
Bystander effect was first demonstrated back in 1954 when cells exposed to low doses of LET radiation were found to have an indirect effect in producing a plasma—borne factor, which led to chromosome breakage and cytogenic abnormalities in human bone marrow or lymphocytes and caused tumors in rats [1]. An experiment conducted by Nagasawa in 1992 proved the existence of Bystander effect. The study showed that irradiation of 1% cells with alpha …show more content…
Addition of the blood serum from the previously mentioned people to a non-irradiated cell culture resulted in chromosomal damage [3]. This effect is mor pronounced in cells that have gap junctions and hence, intercellular relationships between cells is necessary for transfer of signals of radiation induced bystander effects [4].
In other words RIBE is a phenomenon through which the cells irradiated with ionizing radiation release some signaling molecules that affect the non-irradiated cells by transferring through the medium or gap junctions. RIBE possess a challenge to nuclear medicine i.e. utilization of ionizing radiation for the treatment of various diseases.
This can lead to a possible assumption that radiation of a localized area (e.g. radiotherapy) could result in systemic damages and even cause carcinogenesis events. A manisfestation of this can be seen in secondary cancer cases, which have incidence of lung cancer among people who have had radiation therapy to treat prostate cancer [5,6]. Understanding the mechanisms behind these effects can help better target radiotherapy and reduce phenomenon like secondary

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