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Bystander Effect Research Paper

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Radiation Induced Bystander Effect
Bystander effect was first demonstrated back in 1954 when cells exposed to low doses of LET radiation were found to have an indirect effect in producing a plasma—borne factor, which led to chromosome breakage and cytogenic abnormalities in human bone marrow or lymphocytes and caused tumors in rats [2]. An experiment conducted by Nagasawa in 1992 proved the existence of Bystander effect. The study showed that irradiation of 1% cells with alpha particles resulted in a chromatid exchange in more than 30% of the cells. Since the effect was observed in the cells that were not targeted but were in close proximity to the targeted cells; therefore they were called bystander cells and the effect was collect the bystander

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