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Catheter Research Paper

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Introduction
Invasive medical devices are used mainly for diagnostic and therapeutic purposes. Catheter, one of invasive medical devices, is the tubes extruded from different kind of medical grade materials, such as silicone rubber, polyurethane, polyethylene terephthalate and so on.1 They were inserted into a vessel, duct or body cavity.

Background of Medical Problem
Intravascular catheter-associated infections (CAI) always bother the doctors due to bacterial adhesion and biofilm formation. In USA alone, more than 5 million central venous catheters used annually and more than 80,000 of them resulted in CAI.2

Strategies currently used
Metallic Material
Silver has been an antimicrobial material since antiquity and silver nanoparticle are used in modern medical devices. The antimicrobial mechanisms of silver nanoparticle were demonstrated in some reviews.3–5 First, the nanoparticles with large surface area can not only attach to the cell membrane but also penetrate the bacteria, resulting in death.6 Second, silver ion released from silver nanoparticles can react with enzyme or interact with DNA, resulting in prevention of DNA replication.7 …show more content…
8
Hydrophilic coating
Self-autoassembled monolayers (SAMs) was a method for coating. SAMs with hydrophilic moieties (OH, NH2) can reduce bacterial adhesion compared to hydrophobic surface (CH3).9 In addition, heparin or hyaluronic acid can be added to the coating due to hydrophilic properties. 10
Steric barrier structure

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