...Toxicity Paper ENV/410 Toxicity Paper Chemicals that produce systemic toxicity do not always produce the same degree of toxicity in all organs. Instead, one or two organs are usually the target of most of the toxicity produced by the toxic chemical in question. These are the target organs for the toxicity for that chemical. The organ that is the target of toxicity most commonly involved in systemic effects is the central nervous system followed by skin, blood circulation system, liver, lungs and kidneys. Muscle and bones as well as the male and female reproductive systems often suffer debilitating impacts from many substances. Target organs can also refer to an organ is targeted to receive a therapeutic dose of irradiation. An example would be beaming gamma rays to the renal area of a kidney for the treatment of a tumor. Another example of a target organ is the thyroid gland, when the anterior pituitary gland secretes a thyroid stimulating hormone (Silbergeld, 2011). Target organ toxicity is when a toxins adverse effects or disease states manifest in specific organs in the body. The higher the cardiac output, the higher the exposure. Organs each have specialized tissues and cells with differentiated cellular processes and receptors while some toxicants and metabolites may have specific reactive pathways. As pointed out previously, toxicants do not always affect all organs to the same extent. There could be several sites of action and target organs for a particular...
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...Toxicity Paper Chemicals that produce systemic toxicity do not always produce the same degree of toxicity in all organs. Instead, one or two organs are usually the target of most of the toxicity produced by the toxic chemical in question. These are the target organs for the toxicity for that chemical. The organ that is the target of toxicity most commonly involved in systemic effects is the central nervous system followed by skin, blood circulation system, liver, lungs and kidneys. Muscle and bones as well as the male and female reproductive systems often suffer debilitating impacts from many substances. Target organs can also refer to an organ is targeted to receive a therapeutic dose of irradiation. An example would be beaming gamma rays to the renal area of a kidney for the treatment of a tumor. Another example of a target organ is the thyroid gland, when the anterior pituitary gland secretes a thyroid stimulating hormone (Silbergeld, 2011). Target organ toxicity is when a toxins adverse effects or disease states manifest in specific organs in the body. The higher the cardiac output, the higher the exposure. Organs each have specialized tissues and cells with differentiated cellular processes and receptors while some toxicants and metabolites may have specific reactive pathways. As pointed out previously, toxicants do not always affect all organs to the same extent. There could be several sites of action and target organs for a particular toxicant. The same organ could...
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...PWSRCAC September, 2008 ii Abstract This report is a review of the literature on oil spill dispersants published from 1997 to August, 2008. The report identifies and focusses on recent advances in dispersant effectiveness, toxicity, and biodegradation. Other topics such as application, use, behaviour and fate are also covered. The prime motivation for using dispersants is to reduce the impact of oil on shorelines, thus the application must be successful and effectiveness high. As some oil would come ashore, discussion remains on what effectiveness is required to significantly reduce the shoreline impact. A major issue is the actual effectiveness during spills so that these values can be used in estimates for the future. The second motivation for using dispersants is to reduce the impact on birds and mammals on the water surface. The benefits of using dispersants to reduce impacts on wildlife still remain unknown. The third motivation for using dispersants is to promote the biodegradation of oil in the water column. The effect of dispersants on biodegradation is still a matter of dispute. Some papers state that dispersants inhibit biodegradation others indicate that dispersants have little effect on biodegradation. The most recent papers, however, confirm that inhibition is a matter of the surfactant in the dispersant itself and the factors of environmental conditions. It is clear, on the basis of current literature that the surfactants in some of the current dispersant...
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...Impact of Toxic chemical There are many materials used in the workplace that can be hazardous. However, in order for them to affect your health, they must contact the body or be absorbed into the body. When assessing the potential health effects from working with a particular material it is necessary to understand difference between "toxicity" and "hazard". 1. TOXICITY is the ability of a substance to produce an unwanted effect when the chemical has reached a sufficient concentration at a certain site in the body. The more toxic a material is, the smaller the amount of it necessary to be absorbed before harmful effects are caused. The lower the toxicity, the greater the quantity of it necessary to be absorbed. The toxicity of a chemical is generally measured by experiments on animals (quite often rats). If it is measured in terms of the amounts of material necessary to cause death in 50% of the test animals. These values are called LD50 (lethal dose) or LC50 (lethal concentration), and are usually given in weight of material per kg of body weight or airborne concentration of material per set time period respectively. 2. HAZARD is the probability that this concentration in the body will occur. Toxicity is an inherent property of the material. A material may be very toxic, but not hazardous, if it is handled properly and is not absorbed into the body. On the other hand, a material may have a very low toxicity, but be very hazardous. Example: 1. An open container...
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...1 A Critical Evaluation of the Use of Neonicotinoid Insecticides on Human Health Jess A. White School of Health, University of Northampton (2015). Insecticides are universally used, not just by farmers, but by household gardener’s as a way to prevent, mitigate or repel pests. Due to outbreaks of infectious disease in honey bees and amphibians, the use of systematic insecticides has significantly increased over the last 20 years (Mason et al., 2012). And is now thought to be the preferred choice; because of their toxicity and mechanistic action. One type, in particular, seen to show a usage increase is – neonicotinoids - a class of agrochemicals derived from nicotine (a substance found in cigarettes). It is thought this derivative form is solely based on the chemical similarity of the two (Calderon-Segura et al., 2012). First introduced within the 1990’s, neonicotinoids were principally used for their systematic nature. While most insecticides are placed on the surfaces of yielding crops, neonicotinoids are taken up by the roots and translocated to separate areas. This, therefore, makes the plant toxic to certain insect species (Pisa et al., 2014). It is this mechanism of action that has now simultaneously been linked to the adverse impacts on several other invertebrate and vertebrate species (Sluijs et al., 2014). There are currently, five authorised neonicotinoid insecticides available for use in the UK, including (1) acetamiprid, (2) clothianidin, (3)...
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...residential homeowner burning trash has been for centuries the means of disposing refuse in areas that do not have organized garbage collection. As the modern industrial chemical production continues to increase, making products that make everyday life in the modern world more accessible, burning that waste stream at low temperatures products highly toxic compounds releasing not only in the air via smoke but also in ash runoff, and smoke fume condensation on possible food sources. Countless toxicological studies have been conducted on dioxins, furans and polychlorinated biphenyl (PCBs). That information will be leveraged here to compliment the toxicity and pollutant effects of these chemicals, yet the emphasis is not political, environmental, nor humanitarian. It is about highlighting the non-industrial emissions, choices in some cases, and for others the realization, that these toxic chemicals are a result of disposing product we receive from the modern industrialized world. Dioxins, furans and PCBs are unwanted by-products of burning of household trash, oil heating, burning wood stoves, and diesel exhaust smoke, and certain industrial processes. The EPA, now considers non-industrial burning of household wastes in burn barrels to be the largest emissions source of dioxins, furans and PCBs (Dow Chemical, 2014). Dioxins, furans, and PCBs, are all considered toxic to...
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...1. Introduction Packaging has become an integral part of the processing, preservation, distribution, marketing, and even the cooking of foods. Food packaging materials include paper, cellulose products, cellophane, tinplate, aluminium, stainless steel, ceramics, glass, rubber, aluminium foil, plastics and laminates (Mercer, 1990). Since its introduction in the 1950’s, the use of plastic in the packaging industry has increased at a greater rate than any other packaging material due to their low cost and outstanding functional service properties (Hernandez and Giacin, 1998). Packaging materials provide protection for microbiological, chemical, and physical contamination (World Packaging Organisation, 2009). However, components of the packaging material must be safe to the product as well as to the consumers. Food may interact with the packaging materials and this may change the initial mechanical and barrier properties as well as the safety of the product (Sablani and Rahman, 2007). Three types of food packaging interaction are distinguished: (i) migration, (ii) permeation, (iii) and absorption. Migration is the transfer of chemical components from the packaging material to the contained food product (Paneva et al., 2005). The migration of potentially toxic substances from packaging material to foods is a major concern in the selection and use of materials for food packaging because of the possible effect upon human health. In addition, migration of other components...
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...Research Paper: Toxicant MOS 5425 – Advanced Toxicology 2/3/2015 Background This paper will compare and contrast a toxin that affects the nervous system, one that affects the endocrine system and another that affects the cardiovascular system. Identify the characteristics that are shared by these toxins and characteristics of these toxins make these toxins vulnerable to toxicity of these specific systems? Central Nervous System Environmental contamination has exposed humans to various metal agents, including mercury. This exposure is more common than expected, and the health consequences of such exposure remain unclear. Mercury in the past was used in a numerous different activities, and now, exposure to this metal from both natural and artificial sources is significantly increasing. According to Azevedo, et al (2012), numerous studies show that high exposure to mercury can induce the following changes to humans such as the central nervous system, potentially resulting in irritability, fatigue, behavioral changes, tremors, headaches, hearing and cognitive loss, dysarthria, incoordination, hallucinations, and death. Endocrine System According to the Canadian Centre for Occupational Health and Safety, Endocrine disruptors are found in synthetic chemicals used in industrial solvents, lubricants, and their byproducts such as polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dixons. Other examples of endocrine disruptors include bisphenol A (BPA)...
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...CURRICULUM VITAE 1. NAME: Professor Emmanuel Egwu Oti (MFS) 2. MAILING ADDRESS: Department of Fisheries and Aquaculture P.M.B.053, Abakaliki, Ebonyi State. RESIDENTIAL ADDRESS: No 9 Umuoji Street Abakaliki, Ebonyi State. 3. E-Mail ADDRESS: otiegwuemmanuel@yahoo.com 4. DATE OF BIRTH: 24th January 1962 5. LOCAL GOVT. AREA: Afikpo North 6. STATE OF ORIGIN: Ebonyi state 7. NATIONALITY: Nigeria 8. MARITAL STATUS: Married 9. LIST OF DEPENDANTS: (i) Emmanuella Chinyere Oti (wife) (ii) Sandra Ijeoma Egwu-Oti(daughter) (iii) Juliet Chinenye Egwu-Oti (daughter) (iv) Genevieve Chiamaka Egwu-Oti (daughter) (v) Treasure Ifeoma Egwu-Oti (daughter) (vi) Bob-Manuel Chidiebere Egwu-Oti (son) 10. POSOTION AND SALARY SCALE: Professor / UASS 78 11. EDUCATIONAL BACKGROUND: DURATION (i) Ngodo/Amachi Primary School Afikpo. 1970-1975 (ii) Government Secondary School Afikpo. 1975-1980 (iii) Alvan lkoku College of Education, Owerri. 1980-1983 (iv) University of Jos, Jos Nigeria. ...
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...WMRC Greening School’s Green Chemistry Lesson Glue From Milk GS005-008 Objectives 1. Examine how a chemical reaction can change into a new product, 2. Understand how renewable resources can be used in our everyday lives Materials • • • • • • • • • • • • • 2 one-ounce medicine cups Safety goggles Plastic spoon (reuse) Basket-type coffee filter 2 9-once clear (reusable) plastic cups 3-quart package of powdered non-fat milk 1 ½ cups vinegar 8 ounce box of baking soda set of measuring spoons Measuring cup Hot water (1/3 – ½ cup) Plastic or newspaper (to cover table if necessary) Paper for gluing Towels for cleanup Green Chemistry Principles • • Safety first and last Use renewable resources IL State Standards (Science) 11.A, 12.B, 12.C, 12.E, 13.B • Levels Middle School (Use as a demonstration for elementary school) Vocabulary Curd, Whey, Casein, Rennin Time One class period Overview Utilizing renewable resources in the classroom visually illustrates the principles of Green Chemistry. The Milk and Glue activity demonstrates to the students that you can take a renewable resource-milk in this case, and through a chemical reaction, turn it into a usable product such as glue. The activity also shows the students that chemistry can be fun. One batch of glue will be made, although this glue does not have a long shelf life. Procedure 1. 2. 3. 4. Measure ¼ cup of hot water Pout into a clear 9-ounce cup Add 2 tablespoons of powdered mil to the water and...
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...Introduction The Deseret Chemical Depot (DCD) is located 20 miles south of Tooele City and about 50 miles southwest of Salt Lake City. Since its inception, the depot has stored over 42% of the nation’s stockpile of chemical weapons. The stockpile has been stored at the depot since World War II, and the activities needed to administer and destroy the muntions have provided employment for the surrounding communities for more than two generations. These communities lived with this stockpile since before our nation’s movement toward environmental awareness, during (and nearby) land-based nuclear testing and downwind cancer scares, and concurrent today’s convoluted environmental processes mandated by the National Environmental Protect Act (NEPA). While the communities may express a desire to ensure a healthy environment, they also maintain a desire for the depot to continue operating to ensure their own prosperity. They also understand that the government must destroy the stockpile to comply with an international treaty. These concerns may seem to conflict and have resulted in multiple communities that, while voicing their concerns, are willing to remain living near what they consider a potential health risk. To examine this assertion, I will present the public comments submitted for a recent DCD-related Human Health Risk Assessment (HHRA), which also apply to a follow-on Environmental Risk Assessment (ERA). The primary document discussed herein, is a compilation of public comments...
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...comes responsibility to use it wisely and ethically. We torture and heartlessly kill creatures that we arrogantly consider lesser beings simply at our disposal. For something as simple as eye makeup animals are tortured and blinded by tests performed at the laboratory. Where they are hardly fed, often forced to live in filth, and sometimes have their vocal cords removed to keep them quiet (CAAT). We are systematically cutting down the last forest that provides their shelter to farm cattle; we dump toxic chemicals and sewage into the waters in which they live; we wear and display the tusks of the last few of their species in our homes, and we pour cosmetic products into their eyes and body parts to determine the harmful effects they might cause on humans, even though the physiological differentiation between humans and the animals they use is drastic. On a daily basis most people do not see their own degree of unintentional support towards this global dilemma, but when compiled on paper one must question how mankind can, with conscience, commit these acts which shame us as human beings. Animals possess the same kinds of feelings and emotions as human beings, and without anesthesia, they are subjected to the pain as well. Mankind often fails to give animals the respect and rights they deserve, they are treated as lifeless, unfeeling scientific specimens and items that we may manipulate at our own convenience and for vanity’s sake. The Facts of Animal Tests - Laboratory research involving...
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...NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE The Case of the Missing Bees: High Fructose Corn Syrup and Colony Collapse Disorder by Jeffri C. Bohlscheid, School of Food Science, University of Idaho, Moscow, ID Frank J. Dinan, Department of Chemistry & Biochemistry, Canisius College, Buffalo, NY Part I – Changes in the Lives of Bees Almond butter is a delicious, upscale alternative to peanut butter and we love it. But its price has increased nearly three-fold over the last two years while that of peanut butter has changed very little. The reason for this is surprising: almonds are much more dependent on honeybees for pollination than are peanuts. The California almond crop, by far the world’s largest, used an unbelievable 40 billion honeybees to pollinate it in 2005 and about a third of that number of bees is no longer available (Benjamin and McCallum, 2009). Since 2007, nearly a third of the honeybees in North America, Europe, and South America have died for unknown reasons. How important is this to our lives? A U.S. Department of Agriculture/Cornell University study estimates that honeybees pollinate nearly a third of everything that we eat (beeculture.com, 2000). If these bees disappear, fruits, vegetables, and nuts will go with them, meat production will severely decline, and we will be in very bad shape, indeed. Two significant changes have occurred in the world of honeybees in the United States since the mid1970s: (1) there has been a steady increase in the...
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...Green chemistry, also called sustainable chemistry, is a philosophy of chemical research and engineering that encourages the design of products and processes that minimize the use and generation of hazardous substances. Whereas environmental chemistry is the chemistry of the natural environment and of pollutant chemicals in nature, green chemistry seeks to reduce the negative impact of chemistry on environment by preventing pollution at its source and using fewer natural resources. As a chemical philosophy, green chemistry applies to organic chemistry, inorganic chemistry, biochemistry, analytical chemistry, physical chemistry and even chemical engineering. While green chemistry seems to focus on industrial applications, it does apply to any chemistry choice. Click chemistry is cited as a style of chemical synthesis that is consistent with the goals of green chemistry. The focus is on minimizing the hazard and maximizing the efficiency of any chemical choice. In 2005 three key developments in green chemistry were identified: use of superficial carbon dioxide as green solvent, aqueous hydrogen peroxide for clean oxidations and the use of hydrogen in asymmetric synthesis. Examples of applied green chemistry are supercritical water oxidation, on water reactions and dry media reactions. Bioengineering is also seen as a promising technique for achieving green chemistry goals. A number of important process chemicals can be synthesized in engineered organisms, such as shikimate, a Tamiflu...
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...Abstract There is strong interest in "going green," including using products that cause less environmental damage when they are disposed of. In this environmental sciences project, you will compare the toxicity of "green" and conventional liquid detergents using worms as test organisms. Objective The objective of this environmental sciences project is to determine if green detergents are safer for the environment than conventional detergents. Introduction Reduce, reuse, recycle. These are typically known as the three R's of the environment. Every year, Americans throw away billions of containers and other packaging materials that end up in landfills. Reducing the amount of waste you produce is one way to help the environment. Another way to help the environment is to recycle. Many of the things we use every day, like paper bags, soda cans, and milk cartons, are made out of materials that can be recycled. Recycled items are put through a process that makes it possible to create new products out of the materials that come from the old ones. Reusing is another way to help protect the environment. The idea is simple: instead of throwing things away, try to find ways to use them again. The use of grey water to irrigate plants is an example. Grey water is the water produced by showering, cleaning clothes, washing dishes, etc. It does not include human waste (that is called black water, and is not safe to use for irrigation). Clearly, if grey water is to be used for growing...
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