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Deathcap Mushroom

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Lunette Russell
Death cap Mushroom

As suggested by the name, Death cap mushrooms are lethal © Martin Newcombe
Death cap is still the commonest cause of [mushroom] poisoning in Europe’ says Newcombe. A notorious fungus, it is part of the Amanita genus that contains around 600 species, some of which are the most highly toxic in the world. It is believed that this genus alone is responsible for approximately 95% of all mushroom poisonings, with 75% of fatal fungal poisonings attributed to death caps (Amanita phalloides) and the related destroying angel (A. virosa).1The toxicity of the Amanita species is due to the presence of two groups of toxins known as amatoxins and phallotoxins, both multicyclic peptides. It is believed that the death cap contains six related phallotoxins and five or more amatoxins. 2Geoffrey Kibby, a research associate at the Royal
Botanic Gardens at Kew in the UK says that death cap ‘smells like gone-off, sickly sweet honey and they apparently taste really good. But you only need one cap to kill an adult; they are pretty nasty things to eat.’
After someone has eaten the deadly mushrooms, ‘there’s usually a delay between six to 30 hours from ingestion before the symptoms start to present themselves,’ explains Kibby. ‘Typically the person will experience food poisoning-type symptoms: severe abdominal pain, sickness and diarrhea, briefly followed by a day or so of apparent recovery,’ he says. ‘However, the patient

Lunette Russell
Death cap Mushroom

will then relapse and deteriorate quite rapidly due to severe renal and liver failure’ often leading to death.
The less-harmful phallotoxins are responsible for the initial gastrointestinal symptoms, but it is the amatoxins that cause the most damage internally. In particular, α-amanitin has a high specificity for RNA polymerase II in the liver. By inhibiting this enzyme it prevents the formation of mRNA and stops protein synthesis, resulting in cell death and subsequent liver failure. When filtered through the kidneys, the toxin can then be reabsorbed into the bloodstream and re-circulated around the body, causing repeated liver and kidney damage. 3

The amatoxin alpha-amanitin is accountable for causing death, by death caps
The death rate has certainly decreased over the years, thanks to the advances in treatments, according to Kibby. ‘In the US, they have more cases than we do [in the UK], so they’ve had more opportunity to try different treatments. Standard treatments usually involve large doses of penicillin and vitamin C, as well as keeping the liver and kidneys going,’ he says. Blood can be filtered using carbon-column haemodialysis units or attempting organ transplants in severe cases. ‘The latest chemical they are trialing is called Silibilin, which seems to have very effective results,’ says Kibby. Research shows that the drug works by preventing the uptake of the amatoxins by the liver cells and thereby protecting undamaged liver tissue. It also stimulates
DNA-dependent RNA polymerases, resulting in an increase in RNA synthesis.4
But treatment is not always successful and it very much depends on how quickly people are diagnosed after ingestion. Victims who are hospitalized and given treatment almost immediately after ingestion have a mortality rate of around 10%, whereas those admitted 60 hours or more after ingestion have a 50–90% mortality rate.5 In spite of years of detailed research into its toxins, death cap is still the most deadly fungus known, and there’s still no known antidote for humans. Lunette Russell
Death cap Mushroom

REFERENCES

http://www.microscopy-uk.org.uk/mag/indexmag.html?http://www.microscopy-uk.org.uk/mag/artjun00/jpfungi.html http://cbm.msoe.edu/images/contentImages/smartTeams/alumni/2007-08/St.Dominic_RNAPol.pdf http://www.ncbi.nlm.nih.gov/pubmed/9604278 http://www.google.com/patents/WO2014043403A1?cl=en http://www.rsc.org/chemistryworld/2013/03/chemistry-mushroom-fungus
1 J R Hanson, The chemistry of fungi, RSC Publishing, Cambridge, 2008
2 G Kibby, Guide to mushrooms of Britain and Europe, Octopus Publishing, 2006
3 R Phillip, Mushrooms and other fungi of Great Britain and Europe, Pan, London, 1981
4 K Hruby, G. Csomos, M Fuhrmann and H Thaler, Human Toxicology 1983, 2, 183 (DOI:10.1177/096032718300200203)
5 The Bad Bug Book, US Food and Drug Administration, 2nd edn, 2012, p200 http://1.usa.gov/XO6DF6
6 Australian National Botanical Gardens http://bit.ly/10gSeRl
7 M Beuhler, DC Lee and R Gerkin, Ann. Emerg. Med., 2004, 44, 114 (DOI:10.1016/j.annemergmed.2004.03.017)
8 V J Marmion and T E J Wiedemann, J. R. Soc. Med., 2002, 95, 260 (DOI: 10.1258/jrsm.95.5.260)

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