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Discuss the Transmission, Treatments and Global Impacts of Tb and Hiv

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TB

Symptoms: - feelings of sickness or weakness, weight loss, fever, and night sweats. The symptoms of TB disease of the lungs also include coughing, chest pain, and the coughing up of blood. Symptoms of TB disease in other parts of the body depend on the area affected.

Trasmission: TB is an airborne disease. Germs are put into the air when a person with TB disease of the lungs or throat coughs, sneezes or speaks. If an individual breathes in these pathogens they can become infected.

Life cycle of pathogens: Stage 1: Onset (1-7 days)
The bacteria os inhales through the air and is engulfed by the alveolar macrophages. Depending on the strain disease and antimycobacterial capabilities of macrophage the disease will pro cress differently. In many cases the bacteria will reproduce and start the infection.

Stage 2: Symbiosis (7-21 days)
If the macrophages do not successfully kill the bacteria they will reproduce until the macrophage bursts.Then the bacteria are engulfed by other macrophages that arrive from the blood stream. Neither the host or the bacteria id harmed.

Stage 3: Initial Caseous Necrosis (14-21 days)

Development of decease begins when bacterial reproduction slows. The growth of the bacteria slows because as the bacteria reproduce they kill the surrounding macrophages and have fewer cells that they can divide within. The increased number of bacteria also produce anoix condition and reduce the pH. At this point the bacteria can no longer reproduce but can stay alive for long periods of time. The host will kill its own tissues to prevent the spread of disease and the host will test positive for tuberculin.
At this stage the T cells start to recognize the tuberculosis bacteria, which causes the T cells to produce cytokines e.g. INF-gamma.

Stage 4: Interplay of Tissue-Damaging and Macrophage Activating Immune

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