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Dmd Research Proposal

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Proposal: “The effects of taking a break during physical therapy for patients with Duchenne muscular dystrophy”
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Background:
Duchenne Muscular Dystrophy (DMD) or medically known as pseudohypertrophic muscular dystrophy is a genetic, degenerative disorder found predominantly in males. It is a recessive X-linked chromosome that affects approximately 1 in 3,500 male’s worldwide.3 The boys found with Duchenne’s have an absence of the protein, dystrophin, leaving them with continuing loss of muscular function.7
Regardless of current efforts, by the age of twelve, most who suffer from DMD depend upon a wheelchair for mobility.13 The purpose of the study is to delay the progression of DMD in boys between five to ten years of age. The intervention for the study is to apply a period of rest in their physical therapy to allow for their central nervous system to process the information. The central nervous system can take between seven to fourteen days to process information in order for the body to recover.2 With the recovery time given to these patients, we can determine a successful intervention or one that further deteriorates muscle mass. The time breaks allow the central nervous system (CNS) a set period of recovery in order to determine a change in the muscular degeneration rate.
Corticosteroids are a steroid hormone produced in the adrenal cortex. It can also be synthetically made and regularly prescribed to patients with DMD. Corticoid steroids, along with physical therapy, are used to help prolong muscle strength, time frame of walking and standing, and diminish spinal deformities.14
The life expectancy for those with DMD is approximately twenty-five years of age.4 With this concept of delaying the degeneration rates of muscular tissue, we can look at lengthening and preserving life for those who suffer from DMD. This study could be a breakthrough in

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