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Ependymin Synthesis

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Ependymin, a secretory glycoprotein that relates to long-term memory, had only been found in vertebrate species. The protein was proposed to be vertebrate-specific molecules that explain the evolution of the chordate nervous system (Landers et al., 2001; Venter et al., 2001; Ponting and Russell, 2002). Yet the gene that relates Ependymin were found in sea cucumber Holothuria glaberrima in the experiment, which was not found from invertebrates before. Using cDNA synthesis and analysis by common reverse transcription polymerase chain reactions (RT-PCRs), an ependymin-related gene from the sea cucumber H. glaberrima (EpenHg) and cloned related ependymin expressed sequence tags (ESTs) from two other echinoderms (Holothuria Mexicana and Lytechinus

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