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Fluids and Electrolyte Imbalance

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Lung cancer arises from the epithelial of the respiratory track. Lung cancer is the most severe cancer compare to the other cases of cancer. Lung cancer is the number one killer in United States and the world. In this country alone, there are 219440 new cases yearly and 159390 death yearly which is almost 57% of death yearly form lung cancer. These cases of lung cancer account for 14% of all cancer in men and 15% in women every year. (McCance, Huether, Brashers, & Rote, 2010, p. 1299). Although tobacco smoking is the number causes of lung cancer, there are some new cases of lung cancer arising every year without any cause. Cigarette smoking accounts for almost 90% of all lung cancer (http://www.cdc.gov/cancer/lung/basic_info/index.htm) . Other causes of lung cancer can include radon, asbestos, second hand smoking, family history, diet and air pollution. Lung cancer arises from a single changed epithelial cell in the tracheobronchial airways. A carcinogen from cigarette smoke or other predisposing factor like inherited gene bind to a cell DNA and damages it thereby resulting in multiple genetic abnormalities in bronchial cell which include deletion of chromosomes, activation of oncogenes and inactivation of tumor suppressing genes. This damage results in cellular changes, abnormal cell growth and eventually a malignant cell. The DNA undergoes further changes and becomes unstable as the DNA is passed to daughter’s cell. With the accumulation of genetic changes, the pulmonary epithelium undergoes malignant transformation from normal epithelium to eventual invasive carcinoma. Invasive carcinomas can finally metastasis to distant organ in the body like brain, spinal cord, and liver.
In the early stage the clinical manifestation are non-specific and can be insidious. Furthermore, the signs and symptoms depend on the location, degree of metastasis to other regional organ

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