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HPA Stress Response Paper

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Studies have shown that in rodents and nonhuman primates there are individual genetic differences that are influenced by maternal care. This includes, but may not be limited to behavioural responses and the HPA stress response. The development of the HPA stress response in rodents is altered by maternal behaviour by localized tissue effects on gene transcription. This also affects the expression of glucocorticoid receptor in the forebrain, an activity that inhibits HPA activity via negative feedback inhibition. Childhood adversity and familial function are linked to altered HPA responses to stress and are associated with a heightened risk of several forms of psychopathology. Scientific evidence suggests that many psychopathological risk factors linked to suicide, schizophrenia and mood disorders, are associated with decreased hippocampal glucocorticoid receptor expression. …show more content…
McGowan et al. (2009) investigated the effects of this receptor and the promoter in hippocampal samples from victims of suicide, while those that died suddenly due to unrelated causes were used as control subjects. Specifically, the study focused on the NR3Cl promoter of the homolog of the exon 17 section in a rat that is also expressed in the hippocampus of humans. To separate the effects of child abuse from those as a result of suicide, the suicide victims were categorized into groups of those that had suffered child abuse in the past and those that had not. The controls had never suffered child abuse in the past. Structured Clinical Interviews for DSM-III-R I were used to obtain psychiatric diagnoses and 12 hippocampal samples were retrieved from the Quebec Suicide Brain Bank. Genotyping, methylation mapping and expression analyses were studied for the

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