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EBP Searchable Clinical Questions Graded Assignment #2

Armon A. Copeland

NR 500 Foundational Concepts and Applications

Chamberlain College of Nursing

June 8th, 2013

Chamberlain College of Nursing NR 500 Foundational Concepts and Applications

EBP Searchable Clinical Questions

Graded Assignment #2

1. Clinical Question:

In patients with AIDS, what is the average life expectancy among those who take single antiretroviral drugs versus those who do the aggressive Highly Active Antiretroviral Therapy (HAART)? P = Patients with AIDS I = HAART C = single antiretroviral drug O = maximum life expectancy

The reason I chose HIV/AIDS as a topic of study is that I strongly believe that treatment interventions can eliminate the belief that the diagnosis is a death sentence. I have also worked with patients with HIV/AIDS. When patients with HIV develop AIDS, it is important for them to know what treatment options are available to them. As of now, the treatment options are extreme. They entail the administration of antiretroviral drugs that are often used alone depending on the needs of the patient. Antiretroviral “Antiretroviral therapy suppresses the replication of the HIV virus in the body,” (AIDS, 2011). However, the use of combination therapy and highly active antiretroviral therapy (HAART) are becoming increasingly common in the treatment of AIDS. HAART has the potential to be “very effective in reducing the number of HIV particles in the bloodstream,” (AIDS, 2011). However, these are extreme interventions that require the full cooperation not just of patient but of the entire medical team. Patients taking HAART need to be closely, caringly, and conscientiously monitored for side effects. The side effects can be extreme, and the “drugs must be taken every day for the rest of a person’s life,” (“HIV/AIDS, 2011). A patient can become resistant to the treatment; therefore monitoring patients using HAART is crucial. This preliminary investigation simply addresses the difference between outcomes of patients taking singular antiretroviral drugs for AIDS, versus those taking HAART. I fully understand that there are variables that cannot be taken into account in a search like this: such as individual differences in patients and co-existing conditions that might preclude a patient from using HAART or benefitting from the administration of HAART antiretroviral therapy. Chamberlain College of Nursing NR 500 Foundational Concepts and Applications

2. Search: PubMed/MEDLINE

Search Number |P |I |C |O |# of Results |Notes | |1 | |HAART | | |16699 |I searched only for HAART | |2 | | |antiretroviral therapy | |31409

|I cleared the search and searched only for antiretroviral. | |3 | | | |Life expectancy |23962 |I searched only for “life expectancy” | |4 |AIDS | | |Life expectancy |769

|I combined the patient population (AIDS) with “life expectancy.” | |5 |4 |1 |2 |3 |125

|I was surprised to find that when I used all the search terms related to the PICO, I still received 125 hits. There was nothing else I could do to narrow the search so I stopped. | |3. Search: EBSCO/CINAHL

Search Number |P |I |C |O |# of Results |Notes | |1 |AIDS | | | |11946 |Using a basic EBSCO search, I went to CINAHL and searched just for “AIDS” to see how many hits I would get. | |2 | | | |Life expectancy |1717 |I also searched CINAHL and only for the term “life expectancy.” | |3 | | |antiretroviral | |3238 |The term antiretroviral in CINAHL. | |4 | |HAART | | |746 |I cleared and only searched for HAART. | |5 | |4 |3 |2 |11 |This time, I conducted an advanced search in CINAHL and entered HAART, antiretroviral, and life expectancy. Because HAART is a term used almost exclusively with AIDS research, it was not necessary to include the extra field. The results were 11 hits, which is why I stopped. | |4. Search: Google Scholar

Search Number |P |I |C |O |# of Results |Notes | |1 |AIDS | | | |1,980,000 |Just for fun, I wanted to see how many hits just typing AIDS would bring. | |2 | |HAART | | |82500 |HAART alone yielded 82500 hits. | |3 | | |antiretroviral | |290,000 |Just the term antiretroviral yielded a lot of hits. | |4 | | | |Life expectancy |407000 |The term life expectancy yielded a lot of hits, too. | |5 |1 |2 |3 |4 |6040 |I went to “Advanced Scholar Search” and typed in antiretroviral, HAART, and life expectancy. With 6040 hits, I needed to continue narrowing the search but realized that my research question might be too broad to make Google Scholar worthwhile. | |

Chamberlain College of Nursing NR 500 Foundational Concepts and Applications

References

• “AIDS.” The New York Times. 25 Sept 2011. Retrieved online: http://health.nytimes.com/health/guides/disease/aids/overview.html

• “HIV/AIDS.” (2011). CDC. Retrieved online: http://www.cdc.gov/hiv/default.htm

• “Introduction to HIV and AIDS Treatment.” (2011). retrieved online: http://www.avert.org/treatment.htm

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