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Hypothyroidism Research Paper

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Hypothyroidism Hypothyroidism happens due to a lack of production of thyroid hormone from the thyroid gland. Hypothyroidism may be primary or central, primary being the more common one. The most common cause of primary hypothyroidism is autoimmune thyroiditis which is characterized by inflammation and destruction of thyroid tissue. This happens due to infiltration of autoreactive T lymphocytes and circulating thyroid autoantibodies. Hypothyroidism is related to many genetic risk factors and is associated with many other autoimmune disorders such as hashimoto thyroiditis, subacute thyroiditis, painless thyroiditis, and postpartum thyroiditis. One type of hypothyroidism is congenital hypothyroidism which is when an infant is born without thyroid …show more content…
Some of the symptoms involves with congenital hypothyroidism are difficulty eating, hoarse cry, and protruding tongue. Skeletal growth might also be stunted caused by impaired protein synthesis, poor absorption of nutrients, and lack of bone mineralization. Pathophysiology of hypothyroidism involves the loss of thyroid function cause by the lack of production of thyroid hormone and increased release of thyroid stimulating hormone and thyrotropin-releasing hormone. The causes of primary hypothyroidism include autoimmune thyroiditis, surgical loss of the thyroid, and medications.The causes of central hypothyroidism include pituitary failure to stimulate the release of TSH and TRH and example of a reason this would happen is a pituitary tumor, brain injury, subarachnoid hemorrhage, or pituitary infarction. Some of the clinical manifestations of hypothyroidism is decrease metabolism, low basal metabolic rate, cold intolerance, lethargy, and lower basal body temperature. Other signs include myxedema. The treatment for hypothyroidism includes hormone replacement …show more content…
Both deal with hyperglycemia due to defects of insulin secretion. Type one diabetes is one of the most prevalent pediatric diseases. Autoimmune type one diabetes mellitus is autoimmune t-cell mediated and destroys beta cells that reside in the pancreas. The destruction of these beta cells could be caused by genetic susceptibility and environmental factors. The genes or environmental factors cause autoantigens to be expressed on pancreatic beta cells. This then causes cellular and humoral immunity and in turn destruction and apoptosis of the beta cells. This then causes insulin synthesis to decline and cause hyperglycemia. This leads to an increase in glucagon which increases blood glucose by stimulating glycogenolysis and gluconeogenesis. Some of the clinical manifestations include issues with metabolism of fat, protein, and carbohydrates. Glucose will accumulate in the blood and polyuria and thirst. Protein and fat may be broken down due to the lack of insulin which in turn causes weight loss. Some of the short term effect are hypoglycemia, ketoacidosis. Some long term effects are eye problems such as cataracts, kidney disease, and nerve damage. Type two diabetes mellitus is also due to genetic and environmental factors. Some of the more prevalent ones are age, obesity, hypertension, physical inactivity, and family history. The pathophysiology of type two diabetes mellitus involves insulin resistance, chronic

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