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Impotence

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Dengue fever transmission has two generics both epidemic dengue or hyperendemic has become a pandemic ever since the Second World War II, widespread and it is an endemic in more than a hundred over countries in the tropical and subtropical region over the globe. The dengue fever is regulated by both the vector and regulated by the host. It is transmitted to humans through mosquito bites of the genus Aedes eminently A. aegypti but other susceptible species that can transmit this disease are the A.albopictus, A.polynesiensis, and A.scutellaris. The virus is of a single genome RNA type flavivirus derived from the family flaviviridae of which it have four serotypes namely DEN-1, DEN-2, DEN-3, and DEN-4. Upon biting, the dengue virions bind to the Langerhans cells which are crucial in the infectivity of the translation of the viral protein embarking with the entry of RNA virus into the cytoplasm after the fusion of the cell membrane with the virus in an acidified endocytic vesicle. Then the RNA virus is translated and a negative-strand viral RNA is formed which serves as the template for the production of other RNA viruses. It is released to the bloodstream via exocytosis and more reticulocytes will be infected. In a hyperendemic dengue fever, it is delineated by the interminable circulation of multifarious viral serotypes in a place of susceptible hosts.
The aftermath of an Aedes bite is detrimental to the health. Speaking from my friend’s experience that is, she had a gruesome week which started with a high fever and a severe cephalgia as well as aforestated arthralgia and muscle pain which worsened her conditions. Following all these was the starting of rashes which is placed all over her body superseded by the inexorable itch. My friend whom I am talking about is no longer here with us anymore, and the deceased passed away due to hemorrhagic fever which is the austere form of dengue fever. It is saddened that how lowly the public is educated for them to have realized the manifestation of the disease if not my friend could have been saved. As seen here the brunt of dengue fever is that it leads to a high mortality rate, and as estimated by the WHO, there are about 2 billion people around the globe who are at peril. Besides that, dengue fever has become the leading foregoer of child mortality amongst the Asian and some of South American countries.
I do not have a standing ovation on whether life attenuated viral vaccine is the solution but I do agree in some ways it could be one of the ways to cure dengue fever. Quoting an example would be the live attenuated influenza H5N1 vaccine that is constructed using the weakened form of viral H5N1 that codes the genes of the altered and modified H5 hemagglutinin (HA) and a wild-type N1 nueraminidase. The finding shows that it is possible to create such viral vaccine based on the single H5N1 virus which provided protection in the animals that has been used as the guinea pig (mice and ferrets). As these animals show similar anatomical structure to human, they can be used on humans as well.
In any cases, prevention is always better than cure. For that, everyone should be aware of the outbreak of dengue especially the Asians. Simple steps can be taken to avoid miserable results in the future.

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