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Invertebrate Haemoglobin

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1 Introduction
Analysis of globins allow for the evolutionary history of genes and proteins to be deduced (Goodman and Moore, 1973). A globin is a form of protein consisting of eight alpha helices (Dickerson and Geis, 1983 cited in Roesner, et al., 2004). One type of globin in-cludes the myoglobin, which functions within muscles of the heart and skeletal muscles (Hardison, 2012). The haemoglobin, on the other hand, is located within erythrocytes, and conveys oxygen from the lungs, throughout the body, and back to the lungs where it deposits carbon dioxide in exchange for oxygen (Roesner, et al., 2004). This form of protein is constructed by two alpha and two be-ta subunits, which are coded for by eight different haemoglobin genes, which in …show more content…
However, as suggested by Hardison (1998), invertebrate and vertebrate globins should be plotted onto differing clades of the phylogenetic tree. In comparison, the inver-tebrate protein sequence of the mountain pine beetle is plotted onto Fig-ure 1 near the haemoglobin gene zeta and the myoglobin protein se-quence. This may be due to the fact that the present analysis utilized a relatively limited amount of protein sequences from invertebrate animals to compare against the wider range of sequences of vertebrate …show more content…
University of St Andrews, St Andrews, Scotland.
Goldman, N., Anderson, J.P. and Rodrigo, A.G. 2000. Likelihood-Based
Tests of Topologies in Phylogenetics. Systematic Biology, 49(4), pp.652-670.
Goodman, M. and Moore, W. 1973. Phylogeny of Hemoglobin. Syste matic Zoology, 32, pp.508-532.

Hardison, R. 1998. Hemoglobins from bacteria to man: evolution of different patterns of gene expression. Journal of Experimental Biology, 201(8), pp.1099-1117.

Hardison, R.C. 2012. Evolution of Hemoglobin and Its Genes. Cold Spring Harbor Laboratory Press, pp.1-18

Paradis E., Claude J. and Strimmer K. 2004. APE: analyses of phylog enetics and evolution in R language. Bioinformatics 20: 289 290.

R Core Team (2013). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/.

Roesner, A., Fuchs, C., Hankeln T. and Burmester, T. 2004. A Globin Gene of Ancient Evolutionary Origin in Lower Vertebrates: Evidence for Two Distinct Globin Families in Animals. Mo lecular Biology and Evolution, 22, pp.12-20.

Schliep K.P. 2011. phangorn: phylogenetic analysis in R. Bioinformat-ics, 27(4) 592-593

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