...Hindawi Publishing Corporation Obstetrics and Gynecology International Volume 2013, Article ID 173184, 11 pages http://dx.doi.org/10.1155/2013/173184 Review Article Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction Andrea Ciavattini,1 Jacopo Di Giuseppe,1 Piergiorgio Stortoni,1 Nina Montik,1 Stefano R. Giannubilo,1 Pietro Litta,2 Md. Soriful Islam,3 Andrea L. Tranquilli,1 Fernando M. Reis,4 and Pasquapina Ciarmela3 1 Woman’s Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, Italy Department of Gynaecological Sciences and Human Reproduction, University of Padova, Via Giustiniani 3, 35128 Padova, Italy 3 Department of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60126 Ancona, Italy 4 Department of Obstetrics and Gynecology, Federal University of Minas Gerais and National Institute of Hormones and Women’s Health, 30130-100 Belo Horizonte, MG, Brazil 2 Correspondence should be addressed to Andrea Ciavattini; ciavattini.a@libero.it Received 28 February 2013; Revised 10 June 2013; Accepted 13 August 2013 Academic Editor: Hilary Critchley Copyright © 2013 Andrea Ciavattini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Uterine leiomyomas (fibroids...
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...15 January 2011; Accepted 17 March 2011 Academic Editor: Marian Ludgate Copyright © 2011 J. Lindholm and P. Laurberg. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The last part of the 19th century was a period of great achievements in medicine and endocrinology. The thyroid gland evolved from being considered a rudimentary structure to an organ related to specific diseases. The singular importance of iodine became acknowledged. Graves-Basedow’s disease was described. Surgical treatment evolved with extraordinary speed. Theodor Kocher observed that the clinical picture in patients after total thyroidectomy was similar to the one seen in cretinism. In 1850, the first case of hypothyroidism or myxedema was described. Less than 50 years later, effective treatment was introduced. Another 50 years later, autoimmune thyroiditis was ascertained as the most frequent cause of hypothyroidism (in areas with no iodine deficiency). This paper gives a short survey of the history of hypothyroidism and its treatment. 1. Introduction During the 50 years preceding World War I, medicine saw a wealth of new ideas and novel procedures, not in the least within the field of endocrinology. Among major achievements of this period were the recognition of the importance of the pituitary gland, first suggested by Oscar Minkowski (1858–1931)...
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...Clinical guidelines Diagnosis and treatment manual for curative programmes in hospitals and dispensaries guidance for prescribing 2010 EDITION © Médecins Sans Frontières – January 2010 All rights reserved for all countries. No reproduction, translation and adaptation may be done without the prior permission of the Copyright owner. ISBN 2-906498-81-5 Clinical guidelines Diagnosis and treatment manual Editorial Committee: I. Broek (MD), N. Harris (MD), M. Henkens (MD), H. Mekaoui (MD), P.P. Palma (MD), E. Szumilin (MD) and V. Grouzard (N, general editor) Contributors: P. Albajar (MD), S. Balkan (MD), P. Barel (MD), E. Baron (MD), M. Biot (MD), F. Boillot (S), L. Bonte (L), M.C. Bottineau (MD), M.E. Burny (N), M. Cereceda (MD), F. Charles (MD), M.J de Chazelles (MD), D. Chédorge (N), A.S. Coutin (MD), C. Danet (MD), B. Dehaye (S), K. Dilworth (MD), F. Fermon (N), B. Graz (MD), B. Guyard-Boileau (MD), G. Hanquet (MD), G. Harczi (N), M. van Herp (MD), C. Hook (MD), K. de Jong (P), S. Lagrange (MD), X. Lassalle (AA), D. Laureillard (MD), M. Lekkerkerker (MD), J. Maritoux (Ph), J. Menschik (MD), D. Mesia (MD), A. Minetti (MD), R. Murphy (MD), J. Pinel (Ph), J. Rigal (MD), M. de Smet (MD), S. Seyfert (MD), F. Varaine (MD), B. Vasset (MD) (S) Surgeon, (L) Laboratory technician, (MD) Medical Doctor, (N) Nurse, (AA) Anaesthetist-assistant, (Ph) Pharmacist, (P) Psychologist We would like to thank the following doctors for their invaluable help:...
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...ANIMAL PROCEDURES COMMITTEE REVIEW OF COST-BENEFIT ASSESSMENT IN THE USE OF ANIMALS IN RESEARCH JUNE 2003 REPORT OF THE COST-BENEFIT WORKING GROUP OF THE ANIMAL PROCEDURES COMMITTEE PREFACE Letter to the Minister from Michael Banner, Chair of the Animal Procedures Committee 17 June 2003 Dear Ms Flint ANIMAL PROCEDURES COMMITTEE: RECOMMENDATIONS ON COST-BENEFIT ASSESSMENT UNDER THE ANIMALS (SCIENTIFIC PROCEDURES) ACT 1986 On behalf of the Animal Procedures Committee I enclose the Committee’s report on cost-benefit assessment. In it we address the adequacy of the current cost-benefit assessment performed in the course of evaluating project licence applications. We have sought to look at the many issues which arise in relation to this important element of the regulation of the use of animals, but would draw attention to three particular aspects of our work. In the first place we have addressed the fundamental question as to scientific validity of the use of animals. We believe that our considerations and conclusions offer an important clarification of the debate and fulfil the request made by your predecessor, Mike O’Brien, to provide advice on this issue. Secondly, while we conclude that some uses of animals may yield scientific knowledge, we argue that this does not settle the question of justification. We go on to elucidate the full range of factors which must be considered for there to be a rigorous application of the cost-benefit assessment. Thirdly, we also consider how...
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