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Late Onset Alzheimer's Disease

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Genetics of Late Onset Alzheimer’s Disease

Late-onset Alzheimer’s disease (LOAD) is a frightening and expensive disease. Studies show that in 2010 over $215 billion dollars were spent on dementia care, and the condition is among one of the highest diseases that people currently fear getting, second only to cancer (PBS). Scientists are actively searching for clues to determine cause of this disease. Due to the fact that the genetics and risk factors of late-onset are not fully understood, scientists around the globe are actively researching Alzheimer’s disease (AD) and developing theories and finding clues that may help with identifying the causes, genetic risks, and biomarkers or early indicators of the disease. Research into these areas …show more content…
Of the approximately 5 million Americans are afflicted with Alzheimer’s, only about 5% of these patients have actually inherited the early-onset form (which occurs between the ages of 30-60) this form has been shown to be inherited and caused by genetic mutation (NIA). Although LOAD is the most common form of the disease, it is the least understood in terms of the actual cause and probability of inheritance (rare nih).
In the past 25 years there has been major advancements in our understanding of the disease and currently researchers suspect that the late-onset form is a complex condition (rare nih). Complex conditions show evidence of appearing in multiple individuals in families, but it is not a clear-cut pattern of inheritance and even individuals who should be at high risk in developing the disease based on their families’ genetic history may never develop Alzheimer’s. Therefore, it is thought that the disease may be linked to a combination of certain genes and factors such a lifestyle and environment (rare …show more content…
The e2 form of the APOE appears to reduce the risk of Alzheimer’s and is the least common type, e3 is the most common and does not appear to affect the risk, and the e4 variety is fairly common and studies show that this type seems to increase the risk of developing the disease (mayo clinic). You inherit one form of this gene or allele from each parent (PBS). Your risk of developing AD is 3 to 15 times stronger if you acquire one or two of the e4 variants (PBS). Although the e4 type of APOE increases the risk of acquiring the disease, it is important to note that “not everyone who has one or even two e4 genes develops Alzheimer’s. The disease also occurs in many people who do not even have the APOE e4” (mayo). This suggests that other genetic and environmental factors lead to the development of Alzheimer’s, and that APOE e4 does affect the risk but is not the cause of the disease

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