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Lipid Case Study Essay

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DISCUSSION
In the first part of this case control study, we note that VaD participants tend to have a higher lipid profile, do less exercise, and engage less frequently in social interaction and educational or reading activity. They have less fresh vegetables, fish and offal, but more deep fried food. This underscores the recommendation of a healthy lifestyle for the prevention of vascular cognitive impairment.
Lipid disorder
Elevated low-density lipoproteins cholesterol levels increases the risk for VaD in stroke patients,51 52 and also affects amyloid β processing and deposition causing dementia, in particular Alzheimer’s disease. 53
Although statin drugs are effective in preventing recurrent stroke both because of their lipid lowering effect and also their plaque-stabilising effects on vascular function and control over atherosclerosis, their effect on dementia is uncertain. A recent systematic review and …show more content…
Exercise
Higher levels of physical activity seems to be protective for development of VaD, even in the presence of white matter changes, independent of age, education, and other risk factors.33
A systematic review found an association more physical activity was associated with reduced risk of vascular dementia (odds ratio 0.62) when analysing 5 studies with 10,482 patients.58
There is a trial which found that a multidomain intervention (including regular exercise) could improve or maintain cognitive functional abilities in the elderly.59 60
Our observational study appears to support exercise is protective against VaD (controls vs subjects of VaD; OR = 4.2). However, ours is only observational and people with VaD might have less capacity to exercise, therefore result needs to be interpreted with care.
Socialisation and late life cognitive activities
Lower educational level is associated with increased prevalence of VaD. 61

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