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Major Depression Hypothesis

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Major depression (MD) is a heterogeneous group of neuropsychiatric disease associated with significant morbidity, mortality and disability [1,2].. Recently, Diagnostic and Statistical Manual of Mental Disorders (DSM-V), characterized MD by these symptoms depressed mood, diminished interest or pleasure, significant increase or decrease in weight or appetite, insomnia or hypersomnia, pscychomotor agitation or retardation, fatigue, feeling of worthlessness or excessive or inappropriate guilt, inability to concentrate or indecisiveness, and suicidal thoughts. These symptoms reflect alternation in cognitive, psychomotor, biological, motivational, behavioral and emotional processes [1,2]. It is also affects the quality of daily life of community …show more content…
Although this hypothesis in its simple form is insufficient as an explanation of depression, pharmacological manipulation of monoamine transmission remains the most successful therapeutic approach. [11, 12] Therefore, treatment with clinically available antidepressants drug such as nor-epinephrine reuptake inhibitors like amitriptyline, selective serotonin reuptake inhibitors like fluoxetine, atypical antidepressants like trazodone, monoamine oxidase inhibitors like selegiline etc., are effective only in a certain portion of the patients is often associated with more side-effects or adverse effects such as Nausea, vomiting, gastrointestinal discomfort, sexual dysfunction and weight loss, etc. Occasionally, some patients may experience excitement, anxiety, insomnia, restlessness or seizure, blurred vision, difficulty passing urine, and orthostatic hypotension, hypertensive crisis, insomnia, restlessness and these are collectively affected cognition and behavior [10-11]. To obtain better therapeutic benefits and minor adverse reactions, search for alternative antidepressant from natural source i.e., herbal remedies, used traditionally, now documented with safe profile. Therefore, objective of the present review is to explore or enlist some of tradition medicinal plant or plant based formulation and their active phytoconstituents for their anti-depressant like activity using different rodent animal of depression

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