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Multiple Sclerosis (MS)

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What is multiple sclerosis?
Multiple sclerosis (MS) is the prototypical inflammatory demyelinating disease of the central nervous system (CNS) and the most common cause of disability among young adults. Most patients present with a relapsing-remitting illness, characterized by discrete episodes of focal neurological deficit with temporal and anatomical dispersion in the CNS. Although the underlying cause of MS remains unknown, studies have suggested that the pathology of MS begins with the activation and proliferation of T cells in the peripheral lymphoid organs. With the help of MMPs and adhesion mollecules, T cells cross the blood brain barrier(BBB), where they recognize components of the myelin sheath, triggering cytoking relsease and subsequent disruption of the myelin sheath. Damage can be accumulated over time and result in progressive axonal loss and brain atrophy.

What is EAE model? …show more content…
Several different models of MS exist, but by far the best understood and most frequently utilized is the rodent model of experimental autoimmune encephalomyelitis (EAE), which is a T-helper (Th) cell-mediated autoimmune disease characterized by T-cell and monocyte infiltration in the CNS associated with local inflammation. Besides, it is the most widely used model with the closest pathology to MS, displaying features such as axon loss, inflammation and demyelination similar to that of multiple sclerosis (MS). In most animal models of EAE, the diesease can be induced in genetically susceptible animals by active immunization with myelin antigen(s), or by adoptive transfer of myelin-reactive CD4+ T

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