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Naked Mole Rat

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Submitted By gbizzel12
Words 890
Pages 4
Gary Brewer
Dr. Manar Kolta
Biology 1010
16 November 2015
Naked Mole Rat
Naked mole rats are very interesting indeed. They are a result of living underground for long periods of time and they don’t really show the aging process like most other mammals. The live-span of a naked mole rat is crazy long to other mammals up to 30 years [1]. Naked mole rats have a unique way that makes it impossible for cancer to be present in their bodies. The naked mole rat has extremely high super sugar called high-molecular-mass Hyaluronan and mutations in the gene that comes up with it. I chose the naked mole rat because I want the cure to cancer to be found soon. I watched my grandpa suffer from cancer and I don’t think anybody should have to go through it.
No one has ever found cancer in naked mole rats; they appear to be resistant to the disease. Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammals. The naked mole rat lives underground and can live up to 30 years old. They haven’t found any cancer cells in the rodents. This biochemical and physiological characteristics lead to a popular model for cancer research. In this research article there was research done on the rodents in the naked mole rats 66 NMR were detected in them that weren’t detected in 11 other animals. A total of 89 genes were present in the 11 animals that weren’t in the Rodent. [2] Out of these 89 genes 3 are known to be related to cancer. The 11 animals had proteins that were consistent to cancer that the naked mole rat didn’t have. This is results that will narrow down the possible search for genes involved in cancer.
They are the longest-lived rodents, with a lifespan of up to 30 years. The research of the naked mole rat has showed that the brain health is very long for the rodent which is essential to the long life-span of the rat. The naked mole rat live so long due to the conditions they live in; they live under ground. Which they do not see most of the time. Most of the time the naked mole rats close their eyes when they travel through to tunnels. [3] Which the tunnels can be up to six football fields. The naked mole rat has to guard against foreign mole rats and snakes the scientists are trying to find out what genes and the proteins that cause this healthy long levity life. Once found this will be a hall mark in the aging process and help humans live longer lives. The scientists have found 13 proteins that are possible candidates for the wellness of the animal. [4] New possible aspects of the aging process keep getting found out because of the naked mole rat. The proteins are key to finding out the secrets of the aging process to resist against aging.
The naked mole rats anti-aging. The health span in the naked mole rat is crazy compared to other mammals. The molecular attributes that are associated with the naked mole rate are still trying to be studied today. They are being studied so that humans can learn from the aging process of the naked mole rat, to live heathier longer live spans without aging as bad. The scientists found nine proteins that were much altered levels of phosphorylation that are present in the ageing process. [5] These altered proteins are involved in the very slow aging process in the naked mole rat. The high levels of autophagy that was found to be produced the whole lives of the naked mole rat help the aging process. These studies are still on going to see if it can help humans live longer healthier lives.
In conclusion the naked mole rat is the key factor to finding out a lot of human problems from aging to the worst deadly disease known to man in the 21st century aka cancer cells. The naked mole rat in many ways can solve a lot of secrets that need to be solved. We can learn how to stay cancer free. Or we can learn how to live longer healthier lives. The rodent can teach us about the different proteins that can help aging and brain health. Many lives could be saved with more studies on the naked mole rat.

Work Cited
[1] “Naked Mole Rat.” "Web of Science [v.5.19] - All Databases Full Record." Web of Science [v.5.19] - All Databases Full Record. N.p., Oct.-Nov. 2015. Web. 29 Oct. 2015.
[2] “Naked Mole Rat.” "Web of Science [v.5.19] - All Databases Full Record." Web of Science [v.5.19] - All Databases Full Record. N.p., Oct.-Nov. 2015. Web. 29 Oct. 2015.
[3] Nature.com. Nature Publishing Group, 2015. Web. 20 Nov. 2015
[4] “Naked Mole Rat.” "Web of Science [v.5.19] - All Databases Full Record." Web of Science [v.5.19] - All Databases Full Record. N.p., 4 Aug. 2015. Web. 29 Oct. 2015.
[5] “Naked Mole Rat.” "Web of Science [v.5.19] - All Databases Full Record." Web of Science [v.5.19] - All Databases Full Record. N.p., 4 Aug. 2015. Web. 29 Oct. 2015.

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