...a) Why does JJM want to switch Pepcid to OTC when the patent is good for another six years? What would be the optimal time to switch and factors that affect this decision? Would it be the same for all competitors? Firstly, the OTC (over-the-counter) market growth is a huge attraction to pharmaceutical companies, great potential profit can be expected from OTC market. Fierce competition is not avoidable after the patent expires, which may drive down the profit margin. However, some examples, such as Listerine, indicated that OTC product can maintain in the market for a much longer time, because consumers have the tendency to self-diagnose their common ailments, and obtain a drug without prescription. Secondly, Pepcid is a safe drug, and its indication is a common chronic problem in public that is relatively easy to self-diagnose and self-treat. By making such a drug an OTC product, the company can gain access to a larger consumer base and thus gain more profit. Pepcid as a prescription drug has already gained its market as a brand name drug. This creates a demand for the general public for OTC version of Pepcid. Additionally, usually FDA takes several years to process the approval of a prescription-to-OTC switch. Before the patent expires, JJM can take the advantage of patent protection and enter the OTC without competition and thus occupy a larger consumer market earlier. Factors include indication, drug safety, and brand awareness. The indication has to be a common and...
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...Jonathan Frost 1-8-14 Single Phase AC Motors Single phase AC motors are a type of motor that is what the name implies which is one phase. In a single phase AC motors, a single phase motor has voltage and it splits into two phase currents to create a rotating magnetic field to generate the rotor. There are four different types of single phase AC motors and they are called split phase, capacitor, shaded pole, and repulsion. Capacitor and shaded pole is the most common motors they have. A capacitor run motor is connected between a main and auxiliary winding to create a phase shift in between the windings and a rotating flux. Split phase has main and auxiliary winding a centrifugal switch open and remove the auxiliary winding. It reverses at low speed, relatively cheap cost, and it has rapid acceleration. A single coil of a single phase motor doesn’t produce a rotating magnetic field, but a pulsating field could reach maximum intensity at 0 degrees and 180 degrees electrical. A single phase current and can produce two counter rotating magnetic field phases. Permanent-split capacitor motor have one way to solve a single phase problem is to build a 2- phase motor. It requires a motor with 2 windings spaces away 90 degrees electrical and displace two phases of current with 90 degrees in time. Permanent – split capacitor motor has increased current magnitude and also has a backwards time shift as the motor generates the speed pace. The motor works well...
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...requirements for redundant “A” and “B” feeds. | | | |Sec. 4.2 – Clarified requirements for redundant “A” and “B” feeds. | | | |Sec. 9 – Clarified requirement for modem numbering. | |R33c |01/22/2003 |Updated headers and footers. No content changes. | |WARNING: Electrical requirements are specified for Continuous Computing hardware. | |In this document, AC requirements are specified for systems installed in the U.S.A. or Canada. | |For other hardware, and for AC systems in countries other than the...
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...Big as it is, Canepa Design is easy to miss. The discreet boxy building sits just off a busy street in the quiet northern California town of Scotts Valley, just up the winding highway from Santa Cruz. But for car lovers, this place beams like St. Peter’s, an inviting treasure chest stuffed with classic automobiles worthy of pilgrimage. Vintage racing Porsches rub sheetmetal shoulders with iconic ‘60s Ferraris, which sit mere wheel-wells away from the last Shelby Cobra to exit the factory gates. Some vehicles are being restored for their wealthy owners, others are being spiffed up to hit Canepa Design’s showroom, while a few enjoy some mechanical pampering before being returned to their places of honor upstairs in the on-site motorsports museum. “I never get tired of coming to work,” says Bruce Canepa, the racing driver who since 1980 — the heyday of his professional exploits behind the wheel of all manner of Porsche beasts — has quietly turned Canepa Design into one of the foremost auto restoration and classic car sales shops in the nation. “Besides, I’m too obsessed with being in control of all the details to stop coming in.” Obsession and control can be a dangerous cocktail. But not in Canepa’s case. His hands-on personality means the cars coming out of this 70,000-square-foot shop often exceed the exacting standards of his monied clientele. When Canepa leans over the exposed engine bay of the aforementioned 1967 Cobra 427, he points out that “everything on this car...
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...only to examiners who were trained by John E. Reid and Associates. KEELER POLYGRAPH MODEL 6338 The 'Keeler Polygraph' Model 6338 shown here was the first 'Plethysmic Polygraph' manufactured by 'Associated Research' of Chicago, Illinois in the early 1950's. This instrument is the first in the 'Pacesetter Series' which incorporated for the first time a integral photo/optical plethysmograph. The Model 6338 was introduced as a four channel instrument, which recorded simultaneously changes in relative blood pressure, heart rate, pulse wave amplitude, blood volume, oxygenation of the blood, respiration and electrical skin resistance. These reading are obtained by utilizing electronic and pneumatic monitoring. The 6338 required a 115 volt AC current. It weighs twenty-four pounds and is 18" x 11" x 6". The 6338 incorporated newly designed printed circuits, and a new inking system where the pens are fed from removable, individually capped ink bottles with colored ink available. The newly designed vent valves have a positive lock to prevent leak KEELER POLYGRAPH PACESETTER SERIES MODEL 6308 The Model 6308 shown here was manufactured by 'Keeler Polygraph' which was a division of 'Associated Research' of Chicago, Illinois. This instrument was...
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...Instruction Worksheet 1 of 3 Synchronous Motor Load Characteristic n, IL, cos φ, Pout, η = f(M) Objective / Outcome: To recognise the synchronous motor operation. To determine the load characteristics of a synchronous motor. Procedure: 1. Establish the connections according to the diagram below. Experiment 7.1 Instruction Worksheet 2 of 3 Synchronous Motor Load Characteristic n, IL, cos φ, Pout, η = f(M) Experiment 7.1 2. Turn on the DC power supply and adjust the value of the rated excitation current according to the machine name plate. Then, start the motor by using the three phase AC power supply. 3. Measure the speed, armature current, excitation current, power factor and input power from 0 N.m until 2.5 N.m, including the rated torque/load value of 1.72 N.m. 4. Then, calculate the output power, reactive power and efficiency based on the measurements. 5. Represent the speed, armature current, power factor, output power and efficiency as functions of torque/load in a single graph and indicate the rated load on the graph. Analysis and Discussions Provide analysis and discussions based on the graph. Instruction Worksheet 3 of 3 Synchronous Motor Load Characteristic n, IL, cos φ, Pout, η = f(M) Experiment 7.2 Objective / Outcome: To determine the load characteristics of a synchronous motor at constant power factor, cos = 1. Procedure: 1. Establish the connections according to the previous diagram. 2. Apply...
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...This experiment was to determine the amount of Red 40 present in M&M, Skittle and Mike and Ike using the spectrophotometer to determine the wavelength and absorbency. Red 40, also known as Allura Red AC or E129, is a red dye that may cause serious health issues and is also linked to ADHD in children. Based on the article by Vinita Sharma and others “Artificial food colorants are commonly used around the word to enhance the appearance of food.” The stock solution was prepared using 0.168 g/8 L Red Dye 40 the diluted to generate a five-point standard curve for absorbance at 500 nm. A total of nine candies were use three of each type and weighted and recorded. Candies were diluted in 10 ml of distilled water, filter and then poured in 100 ml flask. Distilled water was added to make 100ml solution then a sample was placed in the spectrophotometer for analysis. Figure 1. Plot of Red 40 The mass of Red 40 was 496.42 g /mol. The concentration was calculated to be 4.23*10-5 M. Table 1. Candy Data. Based on the data collected the amount of Red 40 present in red M&M and red Skittle was close to that of the 25% solution created from the stock solution. This amount is a significant amount seen that it is present in all red M&M and Skittle. Even though the Mike and Ike was an orange candy it had a small amount of Red 40 within it. Certainly, Red 40 is present in red M&M, red Skittle, Mike & Ike and also possible in other red or orange candies. This amount...
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...7) econtour Edentulous Ridges—Removal of redundant soft tissue makes impression R taking and fitting complete and partial dentures more accurate and comfortable. Ideal for preparation of ovate pontic sites. Electrode recommendations: #T2; T5; #T8; #T16; #P4. Caution Federal Law restricts this device to sale by or on the order of a properly licensed practitioner. 8) emoval of Hyperplastic and Hypertrophic Tissue—Ideal in case of medication-induced R gingival hyperplasia. Electrode recommendations: #T2; #T5; #T8; #T16; #P4. 9) ericoronitis—Fast, easy removal of pericoronal tissue above partially-erupted third P molars. Electrode recommendations: #T5; #T8; #T16. 1 P 0) erforming Gingivectomy or Gingivaplasty—Predictably reduce depth of shallow periodontal pockets. Electrode recommendations: #T2; #T5; #T8; #T16; #P4. 1) renectomy—Relieve excess muscle tension and tissue pull and improve esthetics. 1 F Electrode recommendation: #T2. 1 2) xposing Teeth with Delayed Eruption—Allow orthodontic eruption to proceed. E Electrode recommendations: #T2; #T5; #T8; #T16. 1 P 3) erforming Tissue Biopsy—Controlled removal of suspect lesions with minimal tissue damage. Electrode recommendations: #T2; #T5. 1 E 4) xposing Pre-Placement Implant Sites—Clean, smooth gingival incisions with control of bleeding for fast exposure of the implant placement site. (IMPORTANT: AVOID CONTACT WITH THE BONE.) Electrode recommendations: #T2; #T8; #T16. 1 )P 5 ...
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...Chapter 01 1.1 Introduction: A storage device may be used to store energy from renewable energy source in DC form which can be converted to AC power by using power inverter. Pulse Width Modulated (PWM) technique may be used to control output rms voltage of the inverter. As the load is variable, the power consumed by the load (PL) may be smaller than the power generated from the renewable energy source (PR). Therefore a Flexible AC Transmission System (FACTS) Controller may be used to supply the additional power (PR – PL) from the renewable energy source to the grid. On the other hand if the power consumed by the load (PL) is greater than the power generated from the renewable energy source (PR) therefore the same FACTS controller may be used to absorb the additional power (PR – PL) from the grid to the load. In this case the FACTS controller must allow bi-directional power flow. If all the active houses are connected to the grid in the same way (proposed way), the active houses that generate more power than the load can be supplied to the active houses that generate less power than the load. Therefore a suitable FACTS controller should be designed in such a way that it can control the power flow in both directions. The idea is illustrated in the following figure. 1.2 Objectives: • Study on different FACTS controllers • Study on different renewable energy sources • Study on different...
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...User Guide Contents Chapter 1. Getting Started 4 7 22 25 30 Before You Start Safety Precautions Proper Posture During Computer Use Overview Turning the Computer On and Off Chapter 2. Using the Computer 33 36 40 42 45 48 49 50 53 56 65 Chapter 1 Getting Started Keyboard Touchpad External-type CD drive (ODD, To be purchased) Multi Card Slot (Optional) Connecting an External Display Device Connecting an External Digital Device Adjusting the Volume Wired Network Wireless Network (Optional) Using the TPM Security Device (Optional) Slim Security Slot Chapter 3. Settings and Upgrade 67 68 69 71 74 75 Chapter 4. Backup/Restore 80 LCD Brightness Control Easy Settings (Optional) BIOS Setup Setting a Boot Password Changing the Boot Priority Battery Samsung Recovery Solution (Optional) Chapter 5. Appendix 92 93 95 97 110 111 112 114 Q&A Important Safety Information Replacement Parts and Accessories Regulatory Compliance Statements WEEE Symbol Information Samsung Packaging Take-Back Program Product Specifications Glossary 2 Chapter 1. Getting Started Before You Start 4 Safety Precautions 7 Proper Posture During Computer Use 22 Overview 25 Turning the Computer On and Off 30 Before You Start Before reading the User Guide, first check the following information. •• Optional items, some devices and software...
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...Model: GH-PAC-12E1 Model: GH-PAC-12E1HP WITH HEAT 12,000 BTU Portable Air Conditioner Operating Instructions Thank you for choosing a Soleus Air Powered by Gree Portable Air Conditioner. This owner’s manual will provide you with valuable information necessary for the proper care and maintenance of your new product. Please take a few moments to thoroughly read the instructions and familiarize yourself with all the operational aspects of your new Portable Air Conditioner. For your own records, please attach a copy of your sales receipt to this manual. Also, write the store name/location, date purchased, and serial number below: Store Name: ____________________________________________________ Location: ______________________________________________________ Date Purchased: _________________________________________________ Serial Number (located on back of unit): ______________________________ IMPORTANT INSTRUCTIONS Before installing and using your portable air conditioner, please read this owner’s manual carefully. Store this manual in a safe place for future reference. 1) Always place the unit on a level surface. 2) Never use or store gasoline or other flammable vapor or liquid near this unit unless instructed by this manual. 3) Maintain at least 12 inches (50 cm) clearance space around this unit. Do not block or cover air inlet or outlet grilles. 4) The unit must be connected to a correctly grounded power supply. 5) Do not start or stop the unit by inserting or pulling...
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...I.0 PROJECT DESCRIPTION I.0 PROJECT DESCRIPTION US ARMY North requires new furniture and equipment for its office located at 1835 Army Blvd, Fort Sam Houston, TX 78235, bldg 2000. The purpose of this procurement is to obtain systems furniture, case goods, and associated design, delivery and installation services for the project. The furniture supplier shall meet with ARMY North representative to determine the functional and aesthetic requirements for 24 workstations equal to or better than ALUR Panel Based system. It shall provide complete specifications including a detailed floor plan, specific model numbers complete with options and finish designations to satisfy the requirements of the customer. The approximate useable square footage (USF) for each room is as follows: Room 2215A -414 sq ft Chaplain-345 sq ft Room 2023-1240 sqft Room 2032-375 sqft Room 2230B-210 sqft The client agency Point of Contact (POC), also noted as the US Army North Project Manager (PM), will be the liaison at all times between the Furniture Contractor and other stakeholders. The Furniture Contractor will be required to comply with the requirements set forth by the Building Owner. The total number of new workstations is approximately 24. Separate sections in this RFQ package include: Attachment A Statement of Work Attachment B Furniture Typicals Attachment C Pricing Forms Attachment E Furniture Technical Characteristics Compliance Matrix Forms 2.0 GENERAL CONDITIONS 2.0 GENERAL...
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...Pepcid AC Racing to the OTC Market Done by:Nikhil Jain H2014020 PGDM-1, HCM Goa institute of Management Case Background Advisers to FDA – Recommended against JJM to sell Pepcid AC (OTC-Version). Companies aiming for OTC Market SmithKline Beecham (TAGAMET) - Treatment only claim Glaxo Eli Wellcome (ZANTAC) - Treatment claim & Prevention claim Lilly (AXID) (PEPCID AC) - Treatment claim & Prevention claim JJM Early mover will have Benefits. OTC ???????????????????????????????????????????? Patent Expiry Why OTC Significant Growth Generic competition Concepts Tested 1. Lasts 8 Hrs/4 times Longer than antacids. 2. Prevents & Treat heartburns and stomach upset. 3. Prescription heritage. 4. One tablet dosage BASES II Results Efficacy – After-use repeat purchase intent. Treatment as preferred choice. Purchase intention (two-top boxes) 82% - Heavy users. 76% - All antacids users. – 11% of population. – 34% of predicted volume. Dual user – Highest trial rate (29%). Pepsid’s First year sales – 2/3rd from existing antacid. – 1/3rd from prescription market. Cannibalization – From Mylanta - 11% of Pepcid AC’s sales. – From Pepsid - 8% of Pepcid AC’s sales. Priced at $2.95 for 6 tablets – would surpass the internal dollar volume hurdle. Focus Groups and Physician & Pharmacists Acid Controller appeared a viable product description. Product endorsement...
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...Pepcid AC: Racing to the OTC Market Case (HBR - 9-500-073) Managers at the Johnson & Johnson/Merck Consumer Pharmaceutical Co. (JJM) are deciding to introduce a new over-the-counter (OTC) heartburn drug. Pepcid has been available by prescription for some time, and JJM was following a trend that began in the 1980s of switching a drug to OTC status before its patent expired. The FDA's advisory group has just recommended against allowing JJM to claim that Pepcid in its lower strength OTC form prevented and relieved heartburn. JJM knew that Pepcid AC's competitors, Smithkline Beecham's Tagamet, Eli Lilly's Axid, and Glaxo Wellcome's Zantac would be available OTC within months of one another, so speed to market was a significant concern. Questions 1. Why does Merck want to switch Pepcid to OTC status when the patent is good for another six years? What would be the optimal time to switch? What determines this optimal time? Would the optimal time be the same for Tagamet, Zantac, Pepcid, and Acid? 2. How will the sales of OTC Pepcid affect the sales of the prescription version? How will cannibalization affect the sales of JJM's Mylanta antacid? Why did JJM buy Malanta if it was planning to switch to Pepcid? 3. What are the relative merits of positioning Pepcid as a "treatment" as opposed to "prevention" of heartburn\indigestion? How does FDA view them? The consumer? JJM? How important is positioning in this market? 4. How can Pepcid simultaneously...
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...Effectiveness of Antacid Tablets by Trisha Dwivdi, 2002 Abstract The purpose of this project was to figure out if antacid tablets are effective in neutralizing the human stomach. Effective was defined to mean that the tablet did not neutralize too much of the solution or too little of the solution compared to other brands. I titrated a solution that had a pH that was similar to the human stomach and tested four brands of popular antacid tablets. The four brands were Pepcid AC®, Zantac 75®, Rolaids®, and Alka Seltzer®. Rolaids® was the only brand that did not neutralize the solution. The other three antacid tablets did work and I decided that antacid tablets are effective in neutralizing the human stomach since they did not neutralize all of the stomach solution or they did not just neutralize a small amount of it. This experiment was all relative to the other tablets, because I had no background information on what defines an antacid tablet to be effective so I had to base it on the results of the other tablets. Rolaids® took an irregular amount of stomach solution compared to the other tablets to neutralize, so I based my results on this observation. Introduction The purpose of doing this project was to figure out if antacid tablets work effectively since there are many tablets out there on the market. I predicted that the antacid tablets will neutralize the stomach solution I made and therefore be effective. I worked in the Breck School Science Lab under...
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