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Propofol Research Paper

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Propofol is an approved synthetically derived hypnotic agent used in the induction and maintenance of anaesthesia or sedation. After its approval, it replaced thiopental as the anaesthetic of choice by hospitals. It was estimated in the year 2010 that propofol accounted for at least 75% of anesthetics given in the U.S.
Pharmacology
Propofol is a small strongly lipophilic molecule which is usually housed in an oil-in-water emulsion. It is administrated through intravenous infusion at a strength of 10mg/100ml, and due to its lack of analgesic potency and may be injected with an analgesic drug.Propofol in the blood plasma is highly protein bound (97-99%) by serum albumin and hemoglobin. The onset of action is usually rapid and unconsciousness can be induced within 15-40sec of administration on average. This is mostly due to the molecules large volumes of distribution and fast distribution from plasma to CNS. Propofol induces hypnosis by significantly increasing the activity of GABAA (β3, β2) receptors and consequently decreasing neuronal activity. Induction of GABAA β3 receptors is theorized to lead to immobility, …show more content…
Propofol should not be used with drugs that cause CNS depression as the drug-drug interaction can increase CNS depression induced by propofol. This, like an overdose of propofol, will lead to cardiorespiratory depression and eventually death if not treated. Based on Rat and Mice Models when an overdose was administrated intravenously death occurred within minutes and was due to respiratory depression. When an Oral overdose was administrated the majority of animal subjects dead within 1-3 days and those that were able to recover from the anaesthesia exhibited decreased activity, locomotor incoordination, hunched posture and

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