...The Post Position Draw of the entries for the Kentucky Derby was held Wednesday, April 29, 2015 at the Churchill Downs Racetrack clubhouse.[8] American Pharoah was installed as the 5-2 morning line favorite.[9] The day after the draw, Todd Pletcher scratched Stanford, stating that the horse was "fine," but they were not pleased with the draw and had been "on the fence" about running in the Derby.[10] On May 1, El Kabeir was scratched due to a possible hoof problem,[11] however the also-eligible Tale of Verve did not get a chance to run since the scratch was made after the cutoff time that allows also-eligible runners to gain a start in the race.[11] Early on race day International Star was also scratched after having problems with his left-front foot.[12] Overall, the 2015 field was considered "the deepest and most talented in decades". Trainer Bob Baffert had the top two favorites: American Pharoah and Dortmund. [13] Dortmund, winner of the Santa Anita Derby, was an undefeated 6–0 entering the race, a feat matched by 1977 winner Seattle Slew and 2004 winner Smarty Jones. American Pharoah was 4–1, having placed fifth in his debut before running off four straight victories, including an eight-length win in the Arkansas Derby.[13] Baffert described the experience as like being "on pins and needles all week long," as reporters and fans expected one of his two horses to win.[13] Other notable horses in the field included the undefeated Florida Derby champion Materiality; Frosted...
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...Autor: santhanam.vikram 09 December 2013 Tags: Words: 723 | Pages: 3 Views: 86 Read Full Essay Join Now! CASE STUDY: TIMBUK2 1.) Consider the two categories of products that Timbuk2 makes and sells. For the custom messenger bag, what are the key competitive dimensions that are driving sales? Are their competitive priorities different for the new laptop bags sourced in China? Some of the competitive advantage which are the key factors of Timbuk2 bags are:- Quality Durable Reliable Not prone to defects Custom made bags for each of the customers The quick delivery of bags The rave review which the company gets for its bags i.e. it basically carries a good name in the market For its laptop bags, even though they are manufactured in china, the designing is done in San Francisco. so the exclusivity remains Cost effective manufacture of laptop bags in china Being able to adopt to changes in demand and fashion By manufacturing the bags in china the company saved the manufacturing cost but lost their niche of manufacturing and selling in America itself. The general perception of it being a Chinese product led to customers felling little betrayed. Also unlike their custom messenger bags they need not worry so much about the delivery time of laptop bags as it is manufactured in advance. 2.)Compare the assembly line in China to that in San Francisco along the following dimensions:(1) volume or rate of production...
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...Timbuk2 is a San Francisco-based company that specializes in manufacturing ready-made and custom-made messenger bags. A messenger bag is also called a courier bag. It is a type of sack, usually made out of some kind of cloth worn over one shoulder and often used by bicycle messengers. To its owner, a Timbuk2 bag is a dependable, everyday companion. Many Timbuk2 bags are worn daily for a decade, or more. It is common for a Timbuk2 bag to outlive jobs. Timbuk2 messenger bags commonly incorporate certain technical features that make them suitable for cycling such as specialized fittings for loosening and tightening the main strap, reflective materials, compression and stabilization straps, and waterproof lining. Timbuk2 is popular among bicycle messengers and cycling enthusiasts. Over the years, Timbuk2 messenger bag has outgrown its working-class roots. It is now increasingly adopted by a growing number of urban, students, and young professionals as a stylish alternative to the ever-present two-strap day pack and the formal black briefcase. Timbuk2 remains faithful as ever to its working-class urban roots, while expanding its city-bred sensibilities to a broader range of products and a wider audience. All its new products share a sense of style, toughness, attention to detail and dedication to quality. Messenger bags are often used as a fashion accessory. Timbuk2 messenger bags are often commonly employed by men to carry bulky items that do not fit into pockets, or a large...
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...cell LH binding capacity, whereas no difference could be detected in the binding affinity of LH to its receptor. Treatment with 8-bromo-cAMP produced a significant increase in specific LH binding; concurrent treatment with PRL (30 ng/ml) produced a significant attenuation of 8-bromo-cAMP action. In addition, treatment with FSH increased the intracellular accumulation of cAMP, and concurrent treatment with PRL did not result in inhibition of the FSH action, as assessed by the generation of intracellular cAMP. Taken together, these findings suggest that the ability of PRL to interfere with FSH action with regard to the induction of LH receptors is exerted at sites distal to those involved in cAMP generation. The effect of PRL on LH receptor messenger RNA (mRNA) levels was not significant during the increase in receptors, whereas after the maximal level of receptor expression was reached, the effect of PRL was apparent. Cotreatment with FSH (30 ng/ml) and increasing doses of PRL inhibited the levels of...
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...------------------------------------------------- Instant Messenger has become one of the most common means of communication. Nearly everyone has it, nearly everyone uses it, and those who use it use it nearly every day. Josh Keys, a guest columnist for the BG News, observes, "As I walked down the hallway to a friend's dorm room, I couldn't help being distracted by a distinct, yet now common tone coming from almost every room in the hall.... Every day since I've been here, I hear the same tunes: . . . the sound of the very trendy AOL Instant Messenger service (Keys 4). According to a survey that I conducted among students at Bowling Green State University, 30 out of 46 respondents said that they spent as much or more time on conversations through Instant Messenger as through e-mail and/or phone. Twenty-one of these respondents reported that they typically spend more than an hour per day using Instant Messenger. (Survey). In a certain sense this is to be expected. Throughout history, old forms of communication have continually been replaced by new ones. Face-to-face conversations were the only way to communicate before the written word. Communication then advanced from letters to telephone conversations, to e-mail, and now on to Instant Messenger. There are many reasons for accepting this new form of communication. It is more convenient, it is popular, and it allows people to control the conversation and project any image they wish. However, the main reason that Instant Messenger is so widely used is that it...
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...Sanil Modi Biol-4910 Summer 2014 M-F Dr. De Vries, Christopher T. Fields The Effects Of Toll Like Receptor 2 Deletion on Social Behavior Neural Network Introduction During this past summer I had the opportunity to conduct research at the Neuroscience Institute at Georgia State University. The research I participated in was under Christopher T. Fields who is working on getting his doctorial degree. In these last few months I have worked on many exiting projects, learned how create experiments and analyze them. From the first day of lab I learned to work with many different lab instruments, software and mastered the structures of the mice brain. The instruments I started working with were a digital microscope and its software Stereo Investigator that took pictures at HD quality of mice brain. Shortly after came the analysis of the pictures we captured and the software used was ImageJ and Excel. In ImageJ you can measure different thresholds of the mice brain and get analysis which is imputed into excel and then the numbers from excel are put into a statistical software where graphs are made and you can check if your experiments had any change from the control. What I also learned was how mice brains are put on a slide. First you would use a cryostat, which slices the mice brain at the amount of thickness needed. While you are slicing the mice brains you are putting them onto a slide. Then they are taken from the slide put into a buffer solution, which lets you add to another...
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...In translation, a cell reads an mRNA message and assembles a polypeptide accordingly; translation can be divided into the same three phases as transcription: initiation, elongation, and termination. During initiation, an mRNA molecule transcribed from DNA is longer than the genetic message it carries. A sequence of nucleotides at either end of the molecule is not part of the message but help the mRNA bind to the ribosome. The role of the initiation process is to establish exactly where translation will begin. This ensures that the mRNA codons are translated into the correct sequence of amino acids. A large ribosomal subunit binds to a small one, creating a function ribosome. The initiator tRNA sits in the P site on the large ribosomal subunit of the ribosome. The P site will hold the growing polypeptide. The other tRNA-binding site called the A site is vacant and read for the next amino acid bearing tRNA. Used tRNAs exit via the E site. An mRNA molecule binds to a small ribosomal subunit. The initiator tRNA with its anticodon, UAC, binds to the start codon, AUG on the mRNA. The initiator tRNA always carries the amino acid methionine (Met). During elongation, the polypeptide chain elongates. The amino acids that make up the polypeptide take their places one at a time once the first amino acids is added. Each addition occurs in a three step elongation process: codon recognition, peptide bond formation, and translocation. During codon elongation, the anticodon of an incoming tRNA...
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...Introduction Timbuk2 has been a San Francisco original since 1989 and has reputation and a loyal following among real-life, hard-working bicycle messengers and cycling enthusiasts. In the case of “The Tao of Timbuk2” the company took some risk of losing its loyal customer base by moving its new productions to China. This paper will address the three questions for the case. 1. Consider the two categories of products that Timbuk2 makes and sells. For the custom messenger bag, what are the key competitive dimensions that are driving sales? Are their competitive priorities different for the new laptop bags sourced in China? The key competitive dimensions driving sales for Timbuk2 are quality and speed of delivery. Product or service is defined by the two characteristics; design quality and process quality allowing for establishing a level of design quality that focuses on the requirement of the customer. (Chase) The most impressive competitive dimension for Timbuk2 is their custom bags are Delivery Speed. Once the order is completed by the customer on the Timbuk2 web site, a custom designed bag reaches the customer two days later. Customers and end consumers now dictate what will be produced, when products will be delivered and what they will pay for that level of service. The local manufacturing for Timbuk2 focus of custom messenger bag is a direct example of the driving need for speed in manufacturing to meet the expectation of customer. Internet ordering capability focuses...
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...It has been suggested that alternative splicing plays a forefront role in creating a complex collection of expressed sequences (mRNA) from a smaller number of genes in humans. In fact, Walter Gilbert had expressed that a variety of mRNA isoforms of one gene arises from different combinations of exon-splicing known as alternative splicing (Modrek & Lee, 2002). Alternative splicing can be classified into several types, with each type being different among species. Exon skipping is a type wherein a cassette exon and its bordering introns are spliced out of the transcript. This type is prevalent in higher eukaryotic forms. Two other types of alternative splicing are alternative 3’ splice site (3’ SS) and 5’ SS selection in which two or more splice sites are identified at one end of an exon. These two types account for a small percentage of alternative splicing in higher eukaryotes. Another type of alternative splicing is intron retention, characterized by an intron persisting in the mature mRNA transcript. It is the rarest type of alternative splicing in both vertebrates and invertebrates, but the most prevalent in plants, fungi, and protozoa (Keren et al., 2010). In the wake of discovering these alternative mRNA forms that diversify protein functions of the same gene, there, however, exists a problem of how to differentiate truly functional forms from those that are not, biologically or otherwise, which further opens up an avenue towards the risk of outright designating a discovered...
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...[pic] NORTHCENTRAL UNIVERSITY ASSIGNMENT COVER SHEET Student: James R Williams THIS FORM MUST BE COMPLETELY FILLED IN Follow these procedures: If requested by your instructor, please include an assignment cover sheet. This will become the first page of your assignment. In addition, your assignment header should include your last name, first initial, course code, dash, and assignment number. This should be left justified, with the page number right justified. For example: |WilliamsJMBA5140-8 | Save a copy of your assignments: You may need to re-submit an assignment at your instructor’s request. Make sure you save your files in accessible location. Academic integrity: All work submitted in each course must be your own original work. This includes all assignments, exams, term papers, and other projects required by your instructor. Knowingly submitting another person’s work as your own, without properly citing the source of the work, is considered plagiarism. This will result in an unsatisfactory grade for the work submitted or for the entire course. It may also result in academic dismissal from the University. | | | |32744 |Dr. Patrick Karbon ...
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...Chapter 7: Timbuk2: The Message Is in the Bag (Summary) Timbuk2, founded in San Francisco more than 15 years ago by former bicycle messenger Rob Honeycutt, manufactures what seems to be a specialized product: messenger bags for cyclists who make their living delivering documents door to door. Today, Timbuk2 still manufactures professional bags for bike messengers. The firm has expanded its offerings to include fashion bags for other consumers-and its goals and plans are much broader than they were fifteen years ago. "Our goal for the future is to remain faithful to our working-class urban roots, while expanding our unique qualities and design sensibilities to a broader range of products and a wider audience," states Timbuk2's Web site. "The difference between strategy and goals is, goals are the endpoint and strategy is the way to get there. The actual steps you take would be the tactics," Dwight explains. Timbuk2's current goal is to move from a tiny, specialized market into a broader market. "Our roots are in the bicycle messenger market ... a subculture that is very interesting.... However, it isn't really a market; there's no growth there. So what we're trying to do is build from that heritage, that authenticity that gives value to our brand as a lifestyle brand," says Dwight. "Then, when we go to sell the company or take it public, there's value there." So every effort, from the development of new products to the marketing of existing ones, focuses...
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...TIMBUK2 1. company overview Timbuk2 is a San Francisco based messenger bags company, established in 1989 by former bike messenger Rob Honeycutt. Just-in-time manufacturing fascinated the founder. He studied the Toyota manufacturing model and developed the Timbuk2 Classic Messenger bag pattern to accommodate custom orders from local bike dealers. Later in 1999 they launched the first online customizer. Its product line has since expanded beyond custom bags, now manufacturing bicycle messenger bags, computer carrying cases and other urban-lifestyle bags. 2. SWOT assessment |Strengths |Weaknesses | |-innovative ideas |staff resitance for new implenatation | |- growing revenues | | |- new product implementation | | |- e-business growth | | |- solidly profitable | | |innovative within the brand | ...
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...Describe how proteins are synthesized Protein synthesis is extremely important for the survival of cells. This process is tightly regulated in order to ensure protein production is properly controlled. Assembly of a protein occurs in several steps, however the two major processes can be outlined as transcription and translation.1 Before understanding the details of how proteins are synthesized, one needs to understand the general notions of DNA. DNA is found within a cell’s nucleus, and protein synthesis occurs in the cytoplasm; therefore genetic information must be transferred from the nucleus to the cell. The first step of protein synthesis is transcription, which involves the formation of messenger RNA (mRNA) from DNA. mRNA holds information about a specific gene which will be carried out of the nucleus. mRNA is single stranded and is the template for protein synthesis. mRNA is simply a complementary copy of one of the strands of the DNA double helix that encodes for a specific protein.2 Transcription can be divided into three main steps: initiation, elongation, and termination. To initiate transcription, the enzyme RNA polymerase binds to a promoter sequence on the DNA strand.3 As a result, the binding causes the double stranded DNA to denature, revealing the template strand and formation of a transcription bubble. mRNA is synthesized within this transcription bubble through the addition of ribonucleotides complementary to the DNA template strand by RNA polymerase....
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...Timbuk2 began like many entrepreneurial businesses—it was started by someone whose need wasn’t being met by the marketplace. A San Francisco bike messenger designed a rugged and stylish shoulder bag to carry during his workday. It was so popular with friends and acquaintances that he soon quit his job to start making the custom bags. The new company attracted devoted customers among young professionals both male and female—and fellow bike messengers—but within a few years it was nearly bankrupt. Backed by private investors and a venture capital firm, Mark Dwight bought Timbuk2 a few years ago and swiftly turned the company around. It now produces more than 30 different products, and its San Francisco factory turns out a bag every 15 minutes. Business has been so good that Timbuk2 recently distributed a total of $1 million in bonuses to its 40 non-management workers to celebrate a banner year with sales of more than $10 million. Production has doubled; more than 1000 specialty retailers in the outdoor, bicycle, and personal computer markets carry Timbuk2 bags nationwide. The company’s e-business arm has tripled in size. Most important, the firm now operates with a positive cash flow and is solidly profitable. When he bought the ailing form, Dwight knew he would have to bring in experienced managers and impose a carefully thought out vision for the future. He put together a team of industry veterans and with their help mapped out a detailed five-year plan that...
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...In “Busy Is a Sickness” Scott Dannemiller argues that there is two different types of busyness and why he needs to change his ways because he is taking what he has for granite. The two types of busyness are “busyness with control” which is created by self-created stress and “busyness without control” that usually affects the poor because the have to work multiple jobs to maintain a healthy lifestyle for themselves and family. In “Busy Is a Sickness” Scott describes that his busyness is busyness with control and that he created his own stress by always having the urgency to rush because of a full schedule that he created. Scott gives an example by explaining how he rushes his kids in the morning to eat fast and to hurry so they won't be late...
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