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Radiotherapy Bystander Effect

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Radiotherapy is used by more than 50% of the cancer patients as a tumor treatment [17]. There can be a few worries even after the treatment is successful, such as a relapse. The risk of secondary cancer caused by radiation exposure only adds to this. This complication of radiotherapy can result in a decrease of the overall survival following the treatment of primary cancer. One the impediment of radiation exposure is bystander effect. This can cause chromosomal damage and may result in carcinogenesis risk in distal cells and tissues. Studies have also shown that the bystander effect is more conspicuous in fractionated doses [19]. Several major cancers that could have a link with the radiation induced bystander effects including cancers of the lung, bronchus, …show more content…
There has been evidence of high incidence of lung cancer in patients with rectal, cervical and ovarian cancer radiotherapy [20, 31, 35]. These results have led to the possible conclusion of a vital role being played by the Bystander effect in their occurrence.
One of the most commonly used cancer treatment is radiation therapy. However, it can lead to damage of healthy tissues and various undesirable, sometimes deadly side effects including local or systemic acute reactions during or a short time after radiotherapy. The effects can in some cases be observed after many years of the therapy. A possible after effect of radiotherapy is an enhanced risk of initiation of new carcinogenic processes and development of further primary cancers; the cumulative incidence of second primary malignancies in patients treated by radiotherapy is estimated to be as high as 20% [36, 37]. New Insights into the mechanisms of the bystander responses, coupled with technological advances in targeting of cells in experimental systems has led to a better understanding of the bystander effect. Irradiated cells communicate signals via bystander effects that result in damage to nearby, non-irradiated cells and eventually

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