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Pathology and Disease Profile Report

1.Primary Major Dx: Paranoid Schizophrenia

2. Definition/Process/Manifestation (Signs and Symptoms): Schizophrenia is a devastating brain disease that affects a person’s thinking, language, emotions, social behavior, and ability to perceive reality accurately. It is described as a psychotic disorder. The term “psychotic” refers to delusions, any prominent hallucinations, disorganized speech, or disorganized catatonic behavior. The lifetime prevalence of schizophrenia is 1% world-wide with no differences related to race , social status, culture, or environment. The most typical age for onset of schizophrenia is during the late teens and early twenties, although cases of onset at age 5 or 6 have been reported. Earlier onset usually happens in males 18-25 y/o, with later onset in females 25-35y/o. These later onset individuals have less evidence of structural brain abnormalities, and have better outcomes. Schizophrenia most likely occurs as result of a combination of inherited genetic factors and extreme non-genetic factors e.g. (virus infection, birth injuries, nutritional factors)., which can affect the genes governing the brain or injure the brain directly. Schizophrenia is not a single disease but a syndrome that involves neurobiochemical and neuroanatomical abnormalities with strong genetic links. It does have a high heritability rate of about 80%.
Substance a buse disorders along with nicotine dependence is very common and may be as high as 80-90%. Depressive symptoms occur, with suicide being the leading cause of premature death in this population.
Early symptoms reveals that during adolescence, the person was withdrawn from others, lonely, and perhaps depressed, and expressed vague or unrealistic plans regarding the future. The person may exhibit dissociative features. As anxiety mounts, indications

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