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Scrapie Research Paper

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Scrapie is a specific type of prion which could cause a central nervous system disease among sheep and goats. Prion is a kind of abnormally folded protein which has “extreme resistance to ionizing and ultraviolet.” (Prusiner, 2) According to current researches, scrapie prions are converted from normal cellular PrP by changing some α-helices into β-sheets. This converting process would change the solubility of the protein and also prevent the protein from digested by proteases. Since researcher has invented techniques to transfer scrapie prions from sheep into mice, scrapie has become the prion people studied the most. As Prusiner mentions in his book, transgenetic studies in prion discovered that “PrPSC acts as a template upon which PrPC is

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