...Septic Shock Medical Careers Institute NUR 255 November 19, 2014 Instructor Y. Rogers Introduction Septic shock is the most common type of circulatory shock. Sepsis or septic shock is systemic inflammatory response syndrome (SIRS) secondary to a documented infection. This response is a state of acute circulatory failure characterized by persistent arterial hypotension despite adequate fluid resuscitation or by tissue hypoperfusion (manifested by a lactate concentration >4 mg/dL) unexplained by other causes. Sepsis can occur in stages that may progress from uncomplicated sepsis, to severe sepsis, to shock. Despite efforts to decrease shock with the use of antibiotics, the incidences continue. Septic shock is the leading cause of death in noncoronary ICU patients. More than 18 million cases of severe sepsis occur each year, this results in 1,400 deaths worldwide every day (Hinkle, 2014). Background In the past, the terms sepsis and septicemia have referred to several ill-defined clinical conditions present in a patient with bacteremia. These 2 terms have often been used interchangeably; however, only about half of patients with signs and symptoms of sepsis have positive results on blood culture. Serious bacterial infections at any site in the body, with or without bacteremia, are usually associated with important changes in the function of every organ system in the body. These changes are mediated mostly by elements of the host immune system against infection...
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...Learner 2 ECS® Program for Nursing Curriculum Integration (PNCI®) Sepsis, Septic Shock and Multiple Organ Dysfunction Syndrome © 2008 METI, Sarasota, FL; Original Authors: Jami Nininger and Dawn Hughes, Mount Carmel College of Nursing, and Thomas J. Doyle, METI. Reviewer: Jami Nininger, Mount Carmel College of Nursing v.4 August 2008 References 1. Differentiate the following terms: • Systemic Infl ammatory Response Syndrome (SIRS) • Sepsis • Severe sepsis • Septic shock • Multiple Organ Dysfunction Syndrome (MODS) 2. Identify the nursing priorities in the care of the patient with sepsis and septic shock. 3. What class of bacteria is responsible for more than one half of the cases of septic shock? What are some common causes of this? 4. Explain why myocardial depression is almost always present in a patient with septic shock despite an initial rise in cardiac output. 5. Discuss the cascade of host infl ammatory responses that produce the major detrimental effects seen in sepsis due to gram-negative bacteria. 6. What is early goal directed therapy in the management of sepsis? 7. Identify the treatment guidelines currently recommended for the management of sepsis and septic shock. 8. Discuss how the drug dobutamine affects cardiac output. Identify the nursing implications with the administration of this drug. 9. Discuss how norepinephrine works and its indications for use. Identify the nursing implications with the administration of this drug. 10. Discuss...
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...Sepsis Alert and Importance of Rapid Treatment for Sepsis Patients Brooke Blackstock Delaware Technical Community College Sepsis remains a huge source of morbidity and mortality in the United States. Although, the mortality rate from severe sepsis was noted to decrease from 39% in 2000 to 27% in 2007 in the United States, more patients required discharge to a long-term care facility. (Kumar, et al., 2011) Due to it’s high morbidity and mortality rate along with the cost for prolonged treatments a number of efforts have now been directed towards improving patient outcomes. Early intervention/treatment for patients suspected of shock is crucial in order to ensure the optimal outcome for the patient. “Early-goal directed” therapy such as patient specific sepsis bundles ordered by physicians, as well as standardized sepsis order sets has been consistently shown improvement in areas such as: time to antibiotics, time to fluid resuscitation, lactate clearance, and mortality. Ensuring that the administration of the appropriate broad-spectrum antibiotics is another important factor that has also decreased mortality. (Hayden, et al., 2016) In order to recognize the need for these interventions in a timely manner, the sepsis alert or “best practice alert” system is implemented into the electronic charting systems used by the facility. This alert system is programed into the hospital’s patient charting system to screen each electronic medical record for patients presenting with...
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...diagnosed in more than 750,000 patients per year and has mortality rates as high as 28%-50%. Septic shock: Is the presence of sepsis with hypotension despite fluid resuscitation along with the presence of inadequate tissue perfusion. Multiple organ dysfunction syndrome (MODS): Is the failure of two or more organ systems in an acutely ill patient such that homeostasis cannot be maintained without intervention. Identify the nursing priorities in the care of the patient with sepsis and septic shock: Oxygenation -Provide supplemental O2 Intubation/mechanical ventilation, if necessary Monitor SvO2 or ScvO2 Circulation- Aggressive fluid resuscitation End points of fluid resuscitation: CVP 15 mm Hg Pawp 10-12 mm Hg Drug Therapies- Antibiotics as ordered Vasopressors (dopamine) Inotropes (dobutamine) Anticoagulants (low molecular –weight heparin) Drotrecogin alfa (xigris) for patients with high risk death Supportive Therapies- Obtain cultures (blood, wound ) before beginning antibiotics Monitor temperature Control blood glucose Stress ulcer prophylaxis What class of bacteria is responsible for more than one half of the cases of septic shock? What are some common causes of this? The main organisms that cause sepsis are gram- negative and gram- positive bacteria. Parasites, fungi, and viruses can also lead to the development of sepsis and septic shock. Explain why myocardial depression is almost...
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...Definitions of systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and multiple organ dysfunction syndrome Systemic inflammatory response syndrome Two or more of the following clinical signs of systemic response to endothelial inflammation: • Temperature > 38°C or < 36°C x Heart rate > 90 beats/min • Tachypnoea (respiratory rate > 20 breaths/min or hyperventilation (Paco2 < 4.25 kPa)) • White blood cell count > 12 ⋅ 109/l or < 4 ⋅ 109/l or the presence of more than 10% immature neutrophils In the setting (or strong suspicion) of a known cause of endothelial inflammation such as: • Infection (bacteria, viruses, fungi, parasites, yeasts, or other organisms) • Pancreatitis x Ischaemia x Multiple trauma and tissue injury x Haemorrhagic shock x Immune mediated organ injury x Absence of any other known cause for such clinical abnormalities Sepsis Systemic response to infection manifested by two or more of the following: • Temperature > 38°C or < 36°C x Raised heart rate > 90/min • Tachypnoea (respiratory rate > 20 breaths/min or hyperventilation (Paco2 < 4.25 kPa)) • White blood cell count > 12 × 109/l or < 4 × 109/l or the presence of more than 10% immature neutrophils Septic shock Sepsis induced hypotension (systolic blood pressure < 90 mm Hg or a reduction of >40 mm Hg from baseline) despite adequate fluid resuscitation Multiple organ dysfunction syndrome Presence of altered organ...
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...Physicians | Today | S/P (Status/Post) R total knee replacement | McNasty Ortho surgeon | Scenario Data | Learning Objectives | Note: This simulation is part of a Microbiology course (MICRO 290). The main learning objective is to use a simulation of sepsis to facilitate student visualization and understanding of the mechanisms of key chemical and biochemical events in the human body during a human pathological scenarioBy the end of this scenario, the participant will be able to: 1. Observes and discusses the use of patient history and assessment data in the early identification and management of patients at risk for or with sepsis, septic shock and multi-system organ dysfunction (ANALYSIS). 2. Observes and discusses the possible diagnostic orders and therapies including medications for the management of patients with sepsis, septic shock and multi-system organ dysfunction. Uses factor analysis to calculate doses of medication (COMPREHENSION, APPLICATION). 3. Applies the microbiology concepts learned throughout the course to explain the physiological outcomes involved in sepsis (COMPREHENSION, APPLICATION, ANALYSIS). The microbiology concepts are the following: a. Sepsis and the immune system – Relate the signs (including labs) and symptoms to the processes in the immune system - Ex....
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...“Evidence-based medicine is the integration of best research evidence with clinical expertise and patient values." (Sackett D, 2009) The nursing profession is liable to humanity for providing high-quality, cost-effective care for patients and families. Thus, the care provided by nurses must be continuously appraised and upgraded on the basis of new and polished research knowledge. The value of the outcome of nursing research not only affected the quality of care delivered to patient but also the power of nurses in making decisions in the health care delivery system. Evidence –Based Practice (EBP) is a continuing process, to address a practical problem with a quality study findings .It is a dynamic integration of ever-evolving clinical expertise and external evidence in day-to-day practice. The definitive goal of nursing process in an EBP is to promotes quality, cost-effective outcomes for patients, families, health care providers, and the health care system (Brown, 2009; Craig & Smyth, 2007; Cullum, Ciliska, Haynes, & Marks, 2008). Second to heart attacks, sepsis is the leading cause of death. As many as 750,000 patients progress into severe sepsis each year in U.S. hospitals, and approximately 200,000 of these patients do not survive yet it is preventable. September is Sepsis Awareness Month and September 13th is World Sepsis Day to raise awareness of sepsis in the hope to increase knowledge resulting in fewer preventable sepsis deaths. In treating sepsis,...
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...What is Sepsis? Sepsis is the most common deadly diseases in the world. Sepsis is serious, often life-threatening illness that happens when an infection cause damage to your tissues and results in an overactive response from your body. Early detection and treatment came make all the difference in your chance of recovery. How can you get sepsis? Sepsis is a result of infection. Four types of infections that are often linked with sepsis are: lungs (pneumonia)kidney (urinary tract infection) skin gut The most frequently identified germs that cause infections that develop into sepsis include: Staphylococcus aureus (staph) Escherichia coli (E. coli) some types of Streptococcus ("What is sepsis?" January 23, 2018, direct quote) Instead of fighting the infection, your immune system response is to attack your body. Anyone can get an infection, and almost any infection can lead to sepsis. Certain people are at higher risk: Adults 65 or older. People with chronic medical conditions, such as diabetes, lung disease, cancer, and kidney disease People with weakened immune systems Children younger than one("What is sepsis?" January 23, 2018, direct quote) Symptoms of Sepsis are Fever and chills, Fast heart rate, confusion, low blood pressure low urine output and rapid breathing are a few signs you should look for. Treatment for sepsis has to happen fast. Doctors and Nurses have to work together to treat it very quickly in order to offer the patient the best chance at recovery. Treatment...
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...As stated earlier, sepsis is a worldwide problem. Sepsis strategies/guidelines are imperative to utilize to make a positive outcome. Becker and Dorman share that “sepsis affects more than 1 million patients a year in the United States and even more patients around the globe and is one the leading causes of death,” (2017, para 1 p 807). With these astounding statistics, it is prudent of nursing educators to perform their part in educating the nursing students on life saving strategies against sepsis. Proactive healthcare is one of the ways this author has grown through her discovery as being a leader in healthcare. Prevention to illnesses is preferred than reacting to the severity of illness. Although not all sepsis cases can be prevented,...
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...C.C. is a previously healthy 27-year-old man admitted to the critical care unit after an accident in which he was hit by a car and dragged along the pavement for nearly 100 feet. He suffered a frontal contusion, fractured clavicle and ribs, and extensive abrasions on his arms, legs, side, back, and buttocks. He was tachycardic, hypotensive, unresponsive, and ventilating poorly when admitted. He was placed on a mechanical ventilator and given IV fluids for shock. C.C. responded well to fluids, with an increase in blood pressure and an improvement in urine output. 1. Based on his case history and responsiveness to fluid therapy, what type of shock was C.C. experiencing? Hypovolemic shock 2. What other clinical findings would be helpful in confirming the type of shock? Capillary refill, tenting on skin turgor, pale skin due to perfusion, and may feel dizzy, faint, nauseated, or very thirsty. 3. Because of his many open wounds and invasive lines, C.C. is at risk for sepsis and septic shock. What clinical findings would suggest that this complication has developed? Bacteremia, high fevers, hot, flushed skin, elevated heart rate, hyperventilation, altered mental status, swelling, and low blood pressure 4. What is the link between sepsis and multiple organ dysfunction syndrome (MODS)? Sepsis causes MODS because the inflammatory and anti-inflmammatory reactions in the body, which cause the clotting cascade to be more active. Resulting in multiple thrombi forming throughout...
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...SHOCK, SURGICAL INFECTIONS & TRAUMA Choose the best answer: 1) More commonly, wound infections following surgery become evident on: A. Between third and fifth day B. Between eight and eleventh day C. Between first and third day D. Between fourth and seventh day E. Between twelfth and sixteenth day 2) The following is an example of Class III surgical wound: A. Urinary bladder surgery B. Herniorrhaphy C. Gastrectomy D. Resection of obstructed bowel E. Surgical drainage of pelvic abscess 3) A 70 yr old victim of an auto-pedestrian accident develops manifestation of severe sepsis 14 days after a Splenectomy. The organism most likely to be involved is: A. Staph. aureus B. Strep. Pyogenes C. Hemophilus influenza D. E. coli E. Klebsiella sp. 4) The most reliable protection for the surgeon against Hepatitis B infection is by: A. adherence to universal precautions B. administration of gamma globulins C. active immunization D. double gloving E. administration of interferons 5) Pro-inflammatory mediators in shock, EXCEPT: A. IL-4 B. IL-2 C. TNF D. IL-6 E. IL-8 6) Hypotension occurs in healthy patients if blood volume is decreased by: A. 15-30% B. More than 40% C. Up to 15 % ...
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...Stable Angina Case 2 Questions: C.C. is a previously healthy 27-year-old man admitted to the critical care unit after an accident in which he was hit by a car and dragged along the pavement for nearly 100 feet. He suffered a frontal contusion, fractured clavicle and ribs, and extensive abrasions on his arms, legs, side, back, and buttocks. He was tachycardic, hypotensive, unresponsive, and ventilating poorly when admitted. He was placed on a mechanical ventilator and given IV fluids for shock. C.C. responded well to fluids, with an increase in blood pressure and an improvement in urine output. 1. Based on his case history and responsiveness to fluid therapy, what type of shock was C.C. experiencing? Hypovolemic Shock 2. What other clinical findings would be helpful in confirming the type of shock? Low blood pressure, weak pulse, cyanosis of the lips and fingertips, shallow breathing 3. Because of his many open wounds and invasive lines, C.C. is at risk for sepsis and septic shock. What clinical findings would suggest that this complication has developed? Chills, light-headedness, little or no urine, palpitations, skin rash or...
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...Emergencies An emergency situation occurs when a person suddenly becomes ill or is injured and requires an immediate medical response. Emergencies can happen at any time. For example, imagine two friends at an amusement park, talking and laughing while waiting in line to ride a rollercoaster. One friend tells the other that she does not feel well. She looks pale. Suddenly, she falls to the ground. If her friend knows what to do, she may be able to prevent further harm to her friend, or even save her life. First Aid In many cases, emergency care may require some form of first aid. In a best-case scenario, emergency care is performed by an emergency care professional. However, in some cases, emergency care procedures are required before a professional can arrive on the scene. For this reason, it is important that the general population and, more importantly, all health care workers know how to perform emergency care. Agencies such as the American Red Cross and the American Heart Association train people to perform these life-saving procedures. Top of Form Question # 1 An emergency situation occurs when a person suddenly becomes ill or is injured and requires an immediate medical response. • [pic]True • [pic]False [pic] Correct Answer. Bottom of Form Top of Form [pic][pic] [pic][pic][pic] Question # 2 In a best-case scenario, emergency care is performed by whom? • [pic]An emergency care professional • [pic]The general population • [pic]A...
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...Clinical guidelines Diagnosis and treatment manual for curative programmes in hospitals and dispensaries guidance for prescribing 2010 EDITION © Médecins Sans Frontières – January 2010 All rights reserved for all countries. No reproduction, translation and adaptation may be done without the prior permission of the Copyright owner. ISBN 2-906498-81-5 Clinical guidelines Diagnosis and treatment manual Editorial Committee: I. Broek (MD), N. Harris (MD), M. Henkens (MD), H. Mekaoui (MD), P.P. Palma (MD), E. Szumilin (MD) and V. Grouzard (N, general editor) Contributors: P. Albajar (MD), S. Balkan (MD), P. Barel (MD), E. Baron (MD), M. Biot (MD), F. Boillot (S), L. Bonte (L), M.C. Bottineau (MD), M.E. Burny (N), M. Cereceda (MD), F. Charles (MD), M.J de Chazelles (MD), D. Chédorge (N), A.S. Coutin (MD), C. Danet (MD), B. Dehaye (S), K. Dilworth (MD), F. Fermon (N), B. Graz (MD), B. Guyard-Boileau (MD), G. Hanquet (MD), G. Harczi (N), M. van Herp (MD), C. Hook (MD), K. de Jong (P), S. Lagrange (MD), X. Lassalle (AA), D. Laureillard (MD), M. Lekkerkerker (MD), J. Maritoux (Ph), J. Menschik (MD), D. Mesia (MD), A. Minetti (MD), R. Murphy (MD), J. Pinel (Ph), J. Rigal (MD), M. de Smet (MD), S. Seyfert (MD), F. Varaine (MD), B. Vasset (MD) (S) Surgeon, (L) Laboratory technician, (MD) Medical Doctor, (N) Nurse, (AA) Anaesthetist-assistant, (Ph) Pharmacist, (P) Psychologist We would like to thank the following doctors for their invaluable help:...
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...dictionary, n.d.). Shock advertising is a marketing strategy that deliberately, rather than unintentionally, startles and offends its audience by violating norms for social values and personal ideals (Wikipedia, 2011). The Free Dictionary continues to state that the shock advertising technique is ideally intended to push boundaries and separate itself from the norm in hopes of attracting an audience and to provoke conversation. As its name states, shock advertising is usually presented in a controversial, bold, and offensive manner. Advertisers are hoping to revolutionize how one views the status quo for the sole purpose of selling a product. Further, shock advertising is created by the use of the images or words that are communicated. Shock advertising may disregard societal manners through nudity or by creating a sense of fear through brutal violence or because the product itself is deemed inappropriate (The free dictionary, n.d.). For example, the clothing brand FCUK’s creative arrangement of letters is unmistakably provocative (B&T, 2004). Shock advertising is not only controversial because of how its message is presented, but also whether it is effective (Wikipedia, 2011). Shock is a successful means of advertising because it creates an emotional persuasion, which ultimately leads to action from the consumer (Huntington, 2009). Thus, shock is useful because it generates action from an emotional reaction, not due to the outrageous images and headlines. Shock advertising is...
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