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Smoking Cessation Paper

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The Success of Smoking Cessation for Patients of Schizophrenia In Relation to Age
Alex B. Dvorak
University of San Francisco

The Success of Smoking Cessation for Patients of Schizophrenia Based on Age
Cigarette smoking is the most abused form of preventable death, counting for almost half a million deaths in the United States annually (Center for Disease Control, 2015). More startling is the prevalence of smoking among people with Schizophrenia; an estimated 53% smoke tobacco (Evins et al., 2014). This rate is up to 5 times higher than the general population, causing an increase in smoking-related death (e.g., Addington, 1998; Dutra, Stoeckel, Carlini, Pizzagalli, & Evins, 2012; Pachas et al., 2013; Zammit et al., 2003). Thus, …show more content…
This increases nicotine dependence, but addiction is strengthened further for those with negative symptoms of Schizophrenia (Pachas et al., 2012). In a study of over 50,000 men, those who smoked cigarettes daily from ages 18-20 were shown to have less chance of developing Schizophrenia later in life. This showed that nicotine has a biological effect on the brain that possibly alters the symptoms of this illness, increasing dependence (Zammit et al., 2003). These findings reveal an effect that nicotine seems to have with negative symptoms of schizophrenia. These negative symptoms can be described as negative affect, a slowing of the brain’s dopamine release causing a weakening of the brain’s reward system. Nicotine increases the release of dopamine in the brain, activating a feeling of reward generally lacking for these patients. This creates a strong dependence on nicotine for feelings of reward or relief in the brain (Dutra et al., 2011). However, over time the forced release of dopamine from nicotine weakens dopamine release, as it begins to become dependent on nicotine for release. This increases negative symptoms, in turn increasing nicotine dependence for relief. Patients of Schizophrenia who smoke usually require a stronger dose of their antipsychotic medications because of nicotine’s manipulation to dopamine release (Addington, …show more content…
The only mediated subject variable was the age; 50 participants were selected for each defined age group using a computerized random selection process. Participants were ages 18 - 70 years, with a confirmed Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnosis of Schizophrenia. All were generally healthy, were taking antipsychotic medication for their symptoms for at least 1 month prior to study, and did not use any recreational substance besides nicotine or caffeine. Every participant was a frequent smoker, with an average of 14 cigarettes smoked per day. Participants were informed of the study in full and signed consent forms, agreeing to begin a dose of the medication and attend CBT once per week. People with suicidal ideation, substance abuse other than nicotine or caffeine, another disease or illness, nicotine use other than cigarettes, or in another medical study were not used in the

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