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The Unwanted Inheritance

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Dementia/Alzheimer’s – The Unwanted Inheritance
Georgeanna L. Chapman
COM/172
June 09, 2014
Janice Prewitt

Dementia/Alzheimer’s – The Unwanted Inheritance It is time to start the day by getting up moving; standing there trying to remember the reason that they are perched there in the kitchen, but their brain isn’t operating correctly. Why can’t they remember what they walked in there for? It wasn’t like this yesterday, or was it is, but with the increasing symptoms of Alzheimer’s setting in, their world is changing, and there is nothing that they can do about it. Yesterday is a blur, today is starting out in a foggy cloud. Even though, environmental factors could contribute to the onset of Alzheimer’s, 25% of all people aged 55 have family history of the disease, 50% of them will inherit the gene mutation. More studies need to be done when it comes to Alzheimer’s; a disease that is increasing in numbers and it is time to put more emphasis on this. With the number of cases rising at a fast rate, women need to stand up and take a stand and demand that more studies be performed as they are more at risk to get Alzheimer’s than Cancer; nearly two-thirds of those with Alzheimer’s are women.
“Alzheimer’s disease was first identified more than 100 years ago but still relatively little is known and understood about the aetiology, pathogenesis, treatment management and prevention of the disease. Diagnosis is difficult, particularly in the early stages, and effective treatments remain elusive.” (Shan, 2013, para.) Alzheimer’s, a gene mutation that causes loss of memory, functions and eventually leads to death. Alzheimer’s played a role in over 500,000 deaths in 2010. According to The Shriver Report, 1 in 6 women will get the disease in comparison to 1 in 11 men. This disease is as real as cancer and needs to be given the same attention. Alzheimer’s is a highly overlooked and understudied disease; therefore, it should be brought up to the front of the line in medical studies. AD (Alzheimer’s disease) is twice more likely to be developed by women in their 60’s than Breast Cancer by the year 2020.

Not only does the age play a significant role in the development of AD, but genetics are also a large factor in the onset of the disease. A person notices small bouts of forgetfulness; why did they come into this room? Why do they have this item in their possession? Where were they going when they left the house? This disease is one of the top 3 reasons for deaths in the United States, yet it is one of the least studied. There needs to be more research done to find out why so many American women are coming down with it. Two-thirds of the 3.2 million persons that have this disease are women according to the Alzheimer’s Associations. (March 2014 ALZ.org fact sheet.)
There have been studies that have proven that if there is family history of AD, the person has a 50% chance of inheriting the disease; not something that they wanted genetically, the same as cancer. It is becoming a major public health concern; something needs to be done. In the early 90’s, there was a study done on gene mutations and early on-set AD. Mutations in three of the genes have been found to cause early-onset familial AD and are inherited in an autosomal dominant fashion (“Alzheimer's disease in Women: A Clinical and Genetics Perspective,” 2009, p. 315). More needs to be found out about these mutations and remove the environment factors as being predisposing. Multiple relatives have inherited AD and people should want to know that they are at a high risk of getting this disease. Predictive genetic testing is a way to find out if a person carries the mutations and this test should be readily available for persons wanting to know.
Finding out that a person may carry the gene mutation is going to be harder as the changes in the health care system continue to roll out. People need to be aware that there are medications that can assist them in helping with the onset of Alzheimer’s, but health insurance may decide that it is not something that the persons need to be tested or treated for. A person can do exercises to work their brain, but it will not stop the disease from eventually escalating to the point where they don’t remember everyday things that happen in their lives from one moment to another. Mameletzi (2013) a growing body of evidence from epidemiological studies indicates that increased physical activity may reduce the incidence of Alzheimer’s disease or delay the progression of the disease in older adults. Exercise is an important cost-effective, safe, non-pharmacological intervention, as it appears to lower the parameters associated with the pathophysiology of the disease, improve cognitive function, functional capacity and quality of life and contribute to the prevention and rehabilitation of co-morbid chronic diseases in the elderly. According to Healy (2003) Effects of Alzheimer’s on the memory-processing area in the brain called the hippocampus; ability of people to fortify their brains to build new networks to bypass areas of injury; possibility that people with better IQs and more education have less risk of developing dementia.(p.29) Mental stimulation can help a person be less likely to develop the disease. Doing crossword puzzles, Sudoku, and reading can significantly increase brain activity and assist in leading an ordinary life. Alzheimer’s isn’t a disease to be taken lightly by any means. People need to think about the statistics and what they can do to try to avoid the onset of the disease. There are different kinds of AD and different degree’s that are associated with it. One of the worse that a person can get is called Sundowners.
With Sundowners, the person will hallucinate and get an angry disposition. They don’t sleep at night; yet sleep all day and will make it hard on their caregiver to be able to care for them properly. They roam at night and this is when person disappears and runs away. They don’t remember what it is they were doing or where they were going. They get lost in this big old world and once confused it becomes a scary situation for them and their family. It puts a lot of stress and worry on family members. They never know when their loved one is going to forget them or think that they are someone else from their childhood. Feeling lost and disorientated, who would want to feel that way? Knowing that AD has a chance to become their future; sometimes knowing makes things easier to accept the disease and to be able to plan for the their time, when they will be part of a needy and growing population.
Finding out that there is a chance they can get this awful disease is something that a person can get some control over before it is too late. With the addition in the last couple of years of medications proven to slow the onset of the disease and give a person as close to normal of a live as they can get; should be something that everyone is allowed to do and should do to make their lives easier. The so-called “AD-epidemic” will inevitably represent a major public health problem to most nations, because to date there is no effective approach in terms of cure or prevention of dementia. (Aprahamian, Stella, & Forlenza, 2013) Alzheimer’s isn’t something to take lightly; if there is a chance that it is in the family history, take all precautions and learn what to do and how to take care before it is too late. Remember that the family history of this disease is not selective. It can happen as early as someone enters their 30’s; it is rare, but it does happen.
More needs to be done to learn about Alzheimer’s disease. They know that there is an inherited factor in this. Gathering more information and getting the facts straight and out to the public is a must. This has been done for other diseases and it should be done for Alzheimer’s. The numbers of deaths associated with this disease are growing to be problematic to society. Eyes need to be opened and this needs to be treated and a major disease and not just something that isn’t a real crisis. Take this threat serious and do something about it while there is still time.

References

The Shriver Report 2010

Alzheimer’s Association March 2014, alz.org

Alzheimer's Disease in Women: A Clinical and Genetics Perspective. (2009, August, September

). AWHONN, 13(4), 314-323. Retrieved from http://http;//journalsCNE.awhonn.org, 2009

Shan, Y. (2013). Treatment of Alzheimer's disease. Primary Health Care, 23(6), 32-38

Mameletzi, D. D. (2013). The role of exercise in the incidence and treatment of Alzheimer's

disease. (English).Archives Of Hellenic Medicine/Arheia Ellenikes Iatrikes,30(5),546-554.

Aprahamian, Ivan., Stella, F., & Forlenza, O. V. (2013, October). New treatment strategies for

Alzheimer's disease: is there a hope?.Indian Journal of Medical Research., 138(4), 449-460.

Healy, B. (2003). Pumping the neurons. U.S. News & World Report,134(23), 29.

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