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Acetaminophen Synthesis

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By utalizing various methodologies including solid-liquid extraction, liquid-liquid extraction, recrystallization, IR spectroscopy, and TLC, the components of Excedrin were seperated, purified and analyzed/identified. Of the 4.0058 grams of excedrin powder 77.80% was recovered yielding 3.1167 grams. The amount of acetimanophen recovered was 1.6283 grams and the amount of aspirin recovered was 1.4884 grams. The solid-liquid extraction successfully extracted the acetaminophen and the melting point range was found to be 168.3ºC to 170.3ºC for the recrystallized substance compared to the 168.4ºC to 170.1ºC for a 50-50 mixture of pure and recrystallized acetimanophene. The calculated retention factor for acetaminophen was 0.273 and no secondary dots (which would indicate a mixture) were …show more content…
The very minor change in melting point and melting point range as well as the absence of any other dots on the acetimanophen lane indecate the seperation of acetimanophen was successful. Analysis of the IR spectum of the sample shows peaks at 3319.86cm-1 (corresponding to N-H group), 3106.93cm-1 (OH group), and 1649.09cm-1 (C=O group), all corresponding to acetaminophens functional groups. The liquid-liquid extraction of asprin and caffiene did not successfuly seperate the components. The aqueous layer containing the deprotonated asprin did end up containing the predicted substance but the organic layer did not contain any caffiene. Analysis of recrystallized asprin resulted in a melting point range of 134.0 ºC to 137.0ºC and a mixed melting point range of 134.2ºC

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