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Amyotrophic Lateral Sclerosis

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Amyotrophic Lateral Sclerosis Throughout our lives we learn and discover the world through our self-regulated abilities to ambulate, laugh, hug, consume, and even breath. Yet there is an aggressive disease known as Amyotrophic Lateral Sclerosis (ALS) that threatens to eliminate our most basic and human capabilities. Over the course of this research paper we will explore various aspects of ALS which include the historical context of ALS, symptoms or characteristics of the disease, causes of ALS on a cellular level, as well as diagnosis and management. In 1869 ALS was first acknowledged by a french neurologist named Jean-Martin Charcot a man historically renowned as the “founder of modern neurology”. However it wasn't until 1939 that …show more content…
ALS is a neurodegenerative disease that affects aspects of the nervous system that control voluntary muscle movement necessary for survival. When we review each aspects of the name ALS (Amyotrophic Lateral Sclerosis) there is a simple descriptive of what defines the nature of this disease. Amyotrophic means “muscles without nourishment” which also alludes to the weakening of the muscle cells as the nerve cells fail to send signals as this disease advances. “Lateral” means “side of” which indicates where the damage of this disease occurs and “Sclerosis” means “hardening or scarring” referring to the scar tissue that develops along the spinal cord. From this we understand that ALS deteriorates the motor neurons in our brain and our spinal cord. These motor neurons are crucial in sending signals to our muscles to move therefore as these neurons deteriorate and eventually disappear, the muscles shrink, grow weak and eventually develop paralysis. When patients lose their voluntary muscle movement they eventually become machine dependent and usually die from respiratory failure. Although there is a strong understand for how ALS affects your body it is still relatively unknown how ALS develops in patients. ALS is defined as “sporadic” and “familial” meaning that 90% of known cases have no hereditary history but 5-10% of the diagnosed cases do carry a family history of the disease. Some of the proposed causes of sporadic ALS include: oxidative stress, mitochondrial dysfunction, immune system abnormalities, glutamate

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