Premium Essay

B Blocker

In:

Submitted By nomankhan
Words 3107
Pages 13
The Management of Hypertension
Allison A. Torbert, Pharm.D. Roberta M. Skoronski, Pharm.D.
Clinical Instructors UW School of Pharmacy

Objectives
• Explain the classification and goals of therapy in the treatment of hypertension based on JNC VI recommendations • Describe nonpharmacologic and pharmacologic treatment approaches • Recognize patients with hypertension and comorbid conditions in order to optimize therapy • Develop an approach to manage hypertensive patients

Prevalence
• Approximately 50-60 million Americans have HTN defined as: systolic BP (SBP) 140 mm Hg or > diastolic BP (DBP) 90 mm Hg or >

• • • •

Incidence increases with age Blacks > whites Men > women Greater in less educated, lower socioeconomic groups

hard disk\course\728-721\htn.ppt

1

Classification of Blood Pressure for Adults Age 18 & Older*
Category
Optimal+ Normal High-normal Hypertension++ Stage 1 Stage 2 Stage 3

Systolic (mm Hg) < 120 < 130 130-139
140-159 160-179 > 180

& & & & & &

Diastolic (mm Hg) < 80 < 85 85-89
90-99 100-109 > 110

*Not taking antiHTN drugs & not acutely ill. When SBP & DBP fall into different categories, highest classification should be used. Isolated systolic HTN defined as SBP > 140 and DBP < 90 and staged appropriately. In addition to classifying accordingly, clinicians should specify presence or absence of target organ disease & additional risk factors + Optimal BP with respect to CV risk is < 120/80; unusually low BP’s should be evaluated for clinical significance. ++Based on avg. of 2 or > readings taken at each of 2 or > visits.

Why treat hypertension?
• Increased risk of the following with increased BP – CVD (nonfatal and fatal) – CHD – Stroke – Renal disease – All cause mortality THE HIGHER THE BP THE HIGHER THE RISK

Why treat hypertension?
• Major risk factor for CHD – Accelerates atherosclerosis – Atimulates

Similar Documents

Premium Essay

Executive Sumary of Surgical Site Infections

...significant improvement in other areas. 100% compliance in all areas will have positive benefits for the patient as well as for the hospital. The goal is to improve compliance in order to ensure patient safety and decrease mortality rates for surgical patients. Assessment Appropriate hair removal and normathermia are two areas that show consistent compliance. Maintaining current processes and procedures is recommended. While antibiotic selection was meeting the desired goal as set forth in the Surgical Care Improvement Project (SCIP) Inf-2, after May a significant decrease in compliance is noted. Use of prophylactic antibiotics prior to incision (SCIP Inf-1), stopping the antibiotic within 24 hrs. of surgery end time (SCIP Inf-3), beta blockers given during perioperative period (SCIP Card-2), recommended VTE prophylaxis ordered (SCIP VTE-1) and given within 24 hrs. prior through 24 hrs. after surgery (SCIP VTE-2) Corrective Action Plan The goal of the prophylactic antibiotic before and after surgery is to promote serum levels and gain bactericidal tissue. There is no known benefit for the patient to continue these antibiotics greater than 24 hrs. post-surgery (qualitymeasures.ahrq.gov, 2013). Physicians have been educated regarding the selection of antibiotics and the importance of administering the first dose within one hour of surgery (jointcommission.org, 2014). Concurrent audits to capture data in real time of these cases will help to ensure compliance by physicians...

Words: 883 - Pages: 4

Premium Essay

Heart Failure

...This assignment will take the form of a case study on a current patient with heart failure being nursed in a community setting. Due to confidentiality and patient privacy, the patient discussed will be referred to as John¹. John is an 82 year old gentleman who lives alone in sheltered accommodation. John’s son and daughter live close and take it in turns to visit daily. John is an ex-smoker who gave up 20 years ago, has long standing hypertension and is overweight having a BMI of 30 kg/m. John was diagnosed with heart failure a year ago after being hospitalised three times in the space of four months. Stewart (2004) feels that a diagnoses of heart failure is problematic in older patients as their symptoms can often mimic other diseases. According to the National Institute for Clinical Excellence Guidelines (NICE) 2003, hospitalisation accounts² for 70% of the £716 million pounds spent on heart failure annually. In this assignment the physiology of the heart will be discussed and how heart failure affects its performance. John’s symptoms, medication and how his condition was diagnosed will be discussed³. John’s future care and how it will be managed along with who will be involved in his care4. NICE (2003) defines heart failure as a “complex syndrome” that results from any structural or functional cardiac disorder that impairs the ability of the heart to function as a pump to support a “physiological circulation”. Tendera5 (2005) states that heart failure...

Words: 2206 - Pages: 9

Free Essay

Creative Change in Healthcare

...Creative Change in Healthcare Mary Ofili HSC 587 May 19, 2014 Lanny A. Kope Creative Change in Healthcare Change in any organization, especially healthcare is a given constant, frequent and always almost inevitable. Several factors may lead to these changes and sometimes, these factors are internal and other times they are external. In the United States, the economy determines the interactions between the cost of healthcare and the way hospitals deliver care to the patients. The current persistent economic downturn continues to force Medicare to look closely at how hospitals are reimbursed and to cut reimbursement rates. With the overhaul of the healthcare system, hospitals have to evaluate how to deliver care to the patients with limited financial resources. Therefore, Medicare expects hospitals to bear the cost of any adverse outcome caused by any changes within the hospital environment. For examples, hospitals are no longer reimbursed for the cost of diabetic ulcer treatment acquired while the patient is in the hospital. The quality of the expected result is much higher while the reimbursement is much lower. Hospitals have to look closely at how the nursing staff delivers care to the patients. The traditional bedside nursing is staffed by three levels of nurses. Certified Nurse’s Assistant (CNA), Licensed Vocation Nurse (LVN), and the Registered Nurse (RN). Other levels of nurses such as Nurse Practitioners and other advanced practice nurses are not included in the...

Words: 1571 - Pages: 7

Free Essay

Study

...VERY IMPORTANT,because you may get a drug you've never heard of it, but will be able to recognize it's category, and the most common side-effects. Once you've done that you should definitely know at the very least these, their side-effects, dangerous drug interactions, safe dosage ranges, etc. Digitalis, Lasix, Nitro, Clozaril, Lithium, Theophylline, Aspirin, Nardil (know all the MAOI's since there are only a couple), Cogentin, know never to mix a MAOI with an SSRI or other antidepressants, Tylenol, Dilantin, Mag Sulfate, and the major cardiac drugs. helps for better memorization                coumadin is highly protein bound. so an increase in protein intake will decrease the effectiveness KCL must be diluted and administered no faster than 20 mEq/hr long-term use of rocephin can cause over-growth of organisms such as Candida albicans Periorbital edema is indicative of post-strept glomerulonephritis After birth, the infant of a diabetic mother is often hypoglycemic epigastric pain can be indicative of an impending seizure variable decelerations indicate a problem with cord compression Clients stered on Disulfiram (Antabuse) must avoid any form of alcohol Tetany is the major sign of hypoparathyroidism nervousness and insomnia suggest an overdose of thyroid hormone replacement therapy remember ELAIN for drugs that can be admin via endotracheal tube (epinephrine, lidocaine, atropine, isuprel, and narcan) ASA can cause hemorrhage during a sickle cell crisis Normal...

Words: 1823 - Pages: 8

Free Essay

Carvedilol

...as Coreg CR. References Press Release, FDA Approves First Generic Versions of Coreg, U.S. Food and Drug Administration, Sep. 5, 2007 Stafylas PC, Sarafidis PA (2008). "Carvedilol in hypertension treatment". Vasc Health Risk Manag 4 (1): 23–30. doi:10.2147/vhrm.2008.04.01.23. PMC 2464772. PMID 18629377. Othman AA, Tenero DM, Boyle DA, Eddington ND, Fossler MJ (2007). "Population pharmacokinetics of S(-)-carvedilol in healthy volunteers after administration of the immediate-release (IR) and the new controlled-release (CR) dosage forms of the racemate". AAPS J 9 (2): E208–18. doi:10.1208/aapsj0902023. PMC 2751410. PMID 17614362. Vanderhoff BT, Ruppel HM, Amsterdam PB (November 1998). "Carvedilol: the new role of beta blockers in congestive heart failure". Am Fam Physician 58 (7): 1627–34, 1641–2. PMID 9824960. Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Mühle C, Terfloth L, Groemer T, Spitzer G, Liedl K, Gulbins...

Words: 554 - Pages: 3

Premium Essay

Nursing Meds

...University of Pennsylvania School of Nursing Medication Tracking Sheet Tracking Medications Across the Curriculum Major Drug Classification (s): beta blocker Generic drug name: Metoprolol Trade (Brand) name: Lopressor Normal dosage range:______25-50mg Safe dosage range: Route(s) of administration: PO once a day Drug action (s): Blocks simulation of beta1 adrenergic receptors. * Uses: * Hypertension. * Angina pectoris. * Prevention of MI and decreased mortality in patients with recent MI. * Management of stable, symptomatic (class II or III) heart failure due to ischemic, hypertensive or cardiomyopathc origin (may be used with ACE inhibitors, diuretics and/or digoxin; Toprol XL only). * * * Significant side effects: fatigue, weakness * Significant adverse reactions: CV- bradycardia, tachycardia, pulmonary edema, hypotension Significant drug/drug interactions: Drug-Drug * General anesthesia, IVphenytoin, and verapamil may cause ↑ myocardial depression. * ↑ risk of bradycardia when used with digoxin, verapamil, diltiazem, or clonidine . * ↑ hypotension may occur with other antihypertensives, acute ingestion of alcohol, or nitrates . * Concurrent use with amphetamines, cocaine, ephedrine, epinephrine, norepinephrine, phenylephrine, or pseudoephedrine may result in unopposed alpha-adrenergic stimulation (excessive hypertension...

Words: 687 - Pages: 3

Free Essay

Top 200 Drugs for 2009 with Classification.Docx

...TOP 200 DRUGS FOR 2009 WITH CLASSIFICATION, ROUTE, AND USE GENERIC | BRAND | CLASS | MAJOR USE | SCHEDULE | ROUTES | atorvastatin | Lipitor | HMA-CoA reductase inhibitor | hypercholesterolemia | not controlled | PO | amoxicillin | Amoxil, Trimox | Penicillin antibiotic | infection | not controlled | PO | hydrochlorothiazide | Microzide | Thiazide Diuretic | Hypertension/edema | not controlled | PO | azithromycin | Zithromax | macrolide antibiotic | infection | not controlled | PO, IV | metformin | Glucophage, Glucophage XR | antidiabetic | Type 2 Diabetes | not controlled | PO | atenolol | Tenormin | beta blocker (B1) | hypertension/angina/acute M.I. | not controlled | PO, IV | Simvastatin | Zocor | HMG-CoA Redctase inhibitor | hypercholesterolemia | not controlled | PO | alprazolam | Xanax, Xanax XR | benzodiazepeine | anxietty/panic disorder | schedule 4 | PO | furosemide | Lasix | loop diuretic | edema/hypertension | not controlled | PO, IV | zolpidem | Ambien, Ambien CR | anxiolytic/hypnotic | insomnia | schedule 4 | PO | potassium chloride | K-Dur, Klor-Con, Micro-K | posassium supplement/electrolyte | hypokalemia | not controlled | PO, IV | sertraline | Zoloft | selective serotonin reuptake (SSRI) | major depression/ocd/panic disorder | not controlled | PO | montelukast | Singulair | leukotriene inhibitor | asthma maintenence | not controlled | PO | escitalopram | Lexapro | selective serotonin reuptake inhibitor (SSRI) | major depression/anxiety...

Words: 2310 - Pages: 10

Free Essay

Case Study

...Mastering the art Memorizing does not have to be as hard as most people make it. The problem is that most people only know how to memorize by reading the same thing over and over again.  * Memorization - The property of permanent terms to be stored in permanent memory and be amenable to retrieval. * How to memorize * Practice Recalling not Repeating * Reading is the way a person gets information from written letters and words. * Speaking from notes- There is a right way and wrong way to use speaking notes when delivering a presentation. The wrong way is to read directly from your notes. The right way is to glance at them throughout your presentation to keep it on track. If you want to use speaking notes, here are a few tips you can use to ensure that you do not end up reading them word for word: * Use speaking notes to capture the outline of your presentation. If you write out everything you want to say, you will likely end up reading it to your audience. * Use speaking notes to capture additional points or points of interest you want to mention. * Put your speaking notes on index cards, instead of full sheets of paper. Index cards are easier to hold (and have less space for notes!). * * Impromptu speaking * without preparation * Made or done without previous preparation: an impromptu address to the unexpected crowds. * Overcome Anxiety and stage fright * The first step in mastering stage fright, and all kinds of...

Words: 728 - Pages: 3

Free Essay

The Nervous System

...The Nervous System Noradrenaline - Noradrenaline is a hormone that is produced naturally by the body. It is synthesized and released by the central nervous system, and also by a division of the autonomic nervous system called the sympathetic nervous system. Norepinephrine acts on target cells by binding to and activating noradrenergic receptors located on the cell surface. It is the main neurotransmitter of the sympathetic nerves in the cardiovascular system and is released as a response to stress. Function: The sympathetic nervous system triggers a response that is commonly referred to as our 'fight or flight response.' When faced with a dangerous situation, our body needs to decide whether to stay and face the problem, or run away. So, In order to make our body work as efficiently as possible, norepinephrine causes several changes in our body function. These include the following: 1. An increase in the amount of oxygen going to our brain - this helps us think clearer and faster. 2. An increase in our heart rate - this pumps more blood around our body, helping our muscles work faster and more efficiently. 3. An increase in glucose (or sugar) release - this additional sugar gives our muscles something to 'feed on,' which helps them work better and faster. 4. An increase in breathing rate - when we breathe faster, we are delivering more oxygen to the body and brain. This helps our entire body work better. 5. A shutting down of metabolic processes...

Words: 843 - Pages: 4

Free Essay

Information Cause and Effect

...GENERIC NAME:LABETALOL - ORAL (luh-BET-uh-lol) BRAND NAMES: Normodyne, Trandate DRUG CLASS AND MECHANISM: Labetalol is a drug that is used for treating high blood pressure. Nerves from the adrenergic nervous system travel from the spinal cord to arteries where they release norepinephrine. Norepinephrine attaches to adrenergic receptors on arteries and causes the arteries to contract, narrowing the arteries, and increasing blood pressure. Labetalol blocks receptors of the adrenergic nervous system. When labetalol attaches to and blocks the receptors, arteries expand, resulting in a fall in blood pressure. GENERIC AVAILABLE: Yes PRESCRIPTION: Yes PREPARATION: Tablets: of 100, 200 and 300 mg; Injection: 5 mg/ml STORAGE: Tablets should be stored between 2-30 C (36-86 F). PRESCRIBED FOR: Labetalol is used alone or in combination with other drugs to reduce blood pressure. DOSING: The recommended starting oral dose of labetalol is 100 mg twice daily and the dose can be increased by 100 mg twice daily every 2-3 days based on the response of the blood pressure. Usual maintenance doses are 200-400 mg twice daily. Patients with severely high blood pressure may require 1.2 to 2.4 g daily. Stopping or changing the dose of the drug should be directed by a physician because serious side effects may occur. The initial intravenous dose of labetalol is 20 mg injected over 2 minutes. Additional injections of 40 or 80 mg may be administered every 10 minutes as needed up to a total dose...

Words: 652 - Pages: 3

Free Essay

Beta-Blockers

...Beta-blockers xxxx Collin College HPRS 1310-WW1 April 15, 2012 The first beta-blocker drug approved by the FDA in 1967 was developed by Sir James Black, an accomplishment for which he was awarded the Nobel Prize in Medicine in 1988 (Stapleton, 1997). Sir Black took a different approach to the treatment of angina pectoris—instead of using drugs to increase the amount of oxygen delivered to the heart, Black sought to find a drug that could reduce the amount of oxygen required by the heart. The drugs in this classification are subdivided into two categories: non-selective and selective (cardioselective). Major drugs in the non-selective beta-blocker category include carteolol, nadolol, penbutolol, pindolol, propranolol, sotalol, and timolol. Major drugs in the cardioselective category include acebutolol, atenolol, betaxolol, esmolol, metroprolol, and nebivolol. Some others, including carvedilol and labetalol also have alpha-adrenergic blocking effects, but are outside the scope of this paper. (Vallerand, 2013; Turley, 2010) Beta-blockers are prescribed for the treatment of hypertension, angina pectoris, cardiac arrhythmias, hypertrophic subaortic stenosis, prevention of myocardial infarction, congestive heart failure, migraine headaches, and glaucoma. (Vallerand, 2013; Hodgson & Kizior, 2013) Beta-blockers work to compete with sympathetic neurotransmitters1 for beta1 and beta2 adrenergic receptor sites. Beta1 receptors are found in cardiac muscle, and beta2 receptors...

Words: 1215 - Pages: 5

Premium Essay

Marketing Manamnet

...Antiarrhythmics Antiarrhythmia drugs are used to treat abnormal heart rhythms resulting from irregular electrical activity of the heart. There are many different types of antiarrhythmic drugs. Examples include: * Tambocor (flecainide) * Procanbid (procainamide) * Cordarone (amiodarone) * Betapace (sotalol) In addition, there are other types of heart drugs that can be used to treat arrhythmias, including: Read the Do You Know Which Symptoms Signal a Heart Attack in Women? article > > * Beta-blockers such as metoprolol or Toprol XL, which reduce the heart's workload and heart rate. * Calcium channel blockers such as Calan, which also reduces the heart rate. There are also a variety of drugs used by the doctor in an emergency situation to control or convert an abnormal heart rhythm. Why Do I Need to Take an Antiarrhythmia Drug? Your doctor has determined that you have an abnormal heart rhythm that would be best treated with drugs alone or in addition to a procedure, such as putting in an implantable cardioverter defibrillator (ICD). Because these drugs only control abnormal heart rhythms, not cure them, you may have to take them for life. Can I Take Other Drugs While Taking Antiarrhythmics? If you are taking an antiarrhythmic, talk to your doctor before taking any other drugs (prescription or over-the-counter), herbal remedies, or supplements. Are There Side Effects Associated With Antiarrhythmics? Yes, antiarrhythmics do have side effects...

Words: 322 - Pages: 2

Premium Essay

Mock Code

...In: Other Topics Mock Code Cardiopulmonary Arrest PNCI - Learner Robert Johnson Age: 60 Weight: 70 kg Base: Stan D. Ardman Patient History Past Medical History: Hypertension well-controlled by medication, hypercholesterolemia and obesity; minor car accident three weeks ago in which he sustained whiplash Allergies: No known drug allergies Medications: Lopressor (metoprolol), Zocor (simvastatin) Code Status: Full Code Social/Family History: Married with two adult children who live locally; Does not smoke, drink or use illicit drugs Handoff Report Situation: The patient is a 60-year-old male in room 425 on the Orthopedic Unit who is recovering from an anterior-posterior interbody fusion of L4 – L5 performed two days ago. His has had an uneventful recovery. He is in his room eating breakfast. Background: Hypertension, hypercholesterolemia and obesity. The hypertension has been well controlled by his medication. He is wearing a soft neck collar for support following a minor car accident three weeks ago in which he sustained whiplash. The patient has no known drug allergies and is awake and alert. Assessment: Vital signs: HR 87, BP 128/62, RR 18, SpO2 has been 98% on room air, Temp 37.1oC Cardiovascular: No telemetry; HR regular Respiratory: Clear in both lung fields GI: Advanced to full liquid diet and tolerating it well GU: Voiding clear, yellow urine Extremities: Pink, warm and with adequate turgor; Movement is strong in all...

Words: 311 - Pages: 2

Free Essay

Discuss Biological or Psychological Methods of Stress Management

...using drugs called Benzodiazepines (BZs). These are the most common type of drug to relieve stress and anxiety issues. They work by slowing down the Central Nervous System activity. GABA, the hormone responsible for anxiety relief naturally in the human body is enhanced by the BZs. The BZs will also help to reduce the serotonin activity in the brain, which is the neurotransmitter which causes stimulation, and reduces anxiety as a result. Benzodiazepines have a number of effects that all lead to the reduction of stress in people without much effort. The other type of drug that could be used to treat stress and anxiety issues are Beta Blockers (BBs). When the body detects stress, the SNS is activated which leads to raised heart rate, which leads to higher blood pressure which can lead to Chronic Heart Disease, heart attack, stroke etc. The Beta Blocker is taken then and it acts by reducing activity of adrenaline and noradrenaline and also binds to the receptors of the heart and other areas of the body stimulated by arousal. As a result of blocking these receptors, it is therefore harder to stimulate them and so the heart beat is slowed, and therefore lower blood pressure. An advantage of drugs is that they work very quickly and are effective in reducing stress almost immediately. Their use can be therefore be justified, provided that the stressor is a short-term one rather than a long-term one. Another advantage is that drugs are also relatively inexpensive compared to psychological...

Words: 420 - Pages: 2

Free Essay

Li Solaiman

...SIROY, Shanayne SOLAIMAN, Alyssa PATIENT D: Acetazolamide 250mg Levodopa/Carbidopa 25/250 Pilocarpine 4% Reserpine 0.25mg Diltiazem 30mg Vitamin B Complex with Vitamin C Entacapone Tablets Tolcapone POSSIBLE DRUG INTERACTIONS LEVODOPA + DILTIAZEM Levodopa and diltiazem may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. MONITOR: The hypotensive effects of levodopa and antihypertensive agents may be additive. Postural hypotension may occur. MANAGEMENT: Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Dose adjustments of the antihypertensive agent may be required. Patients should be advised to notify their physician if they experience dizziness or syncope. LEVODOPA...

Words: 1620 - Pages: 7