Bio230 Final Exam Question Essay

In: Science

Submitted By srhsbriann
Words 673
Pages 3
Iron is an essential trace element for many cellular functions. Iron uptake is accomplished with the aid of 2 proteins:
• Transferrin, a soluble protein which binds to Fe
• A Transferrin receptor, a transmembrane protein which binds the Transferrin/Fe
complex.
Using the table below, list each step in the Fe uptake process. Number each step and
include a description of each step. Be sure to include the events of each step and
any environmental conditions that are required or determine the action of the
molecules involved. (15 pts.)
Note: You must use the table below for your answers. While you do not need to use
every row, YOU CAN NOT CREATE MORE ROWS.

Transferrin without Fe bound does
not interact with its receptor and circulates in the
bloodstream until it catches an Fe ion. Once iron
is bound, the iron–transferrin complex can bind to
the transferrin receptor on the surface of a cell and
be endocytosed. under the acidic conditions of the
endosome, the transferrin releases its iron, but the
transferrin remains bound to the transferrin receptor,
which is recycled back to the cell surface, where it
encounters the neutral pH environment of the blood.
The neutral pH causes the receptor to release the
transferrin into the circulation, where it can pick up
another Fe ion to repeat the cycle. The iron released
in the endosome, like the LDL in Figure 15–33, moves
on to lysosomes, from where it is transported into the
cytosol.
The system allows cells to take up iron efficiently
even though the concentration of iron in the blood
is extremely low. The iron bound to transferrin is
concentrated at the cell surface by binding to transferrin
receptors; it becomes further concentrated in clathrincoated
pits, which collect the transferrin receptors.
In this way, transferrin cycles between the blood and
endosomes, delivering the iron that cells need…...

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