Bio230 Final Exam Question Essay

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Iron is an essential trace element for many cellular functions. Iron uptake is accomplished with the aid of 2 proteins:
• Transferrin, a soluble protein which binds to Fe
• A Transferrin receptor, a transmembrane protein which binds the Transferrin/Fe complex. Using the table below, list each step in the Fe uptake process. Number each step and include a description of each step. Be sure to include the events of each step and any environmental conditions that are required or determine the action of the molecules involved. (15 pts.)
Note: You must use the table below for your answers. While you do not need to use every row, YOU CAN NOT CREATE MORE ROWS.

Transferrin without Fe bound does not interact with its receptor and circulates in the bloodstream until it catches an Fe ion. Once iron is bound, the iron–transferrin complex can bind to the transferrin receptor on the surface of a cell and be endocytosed. under the acidic conditions of the endosome, the transferrin releases its iron, but the transferrin remains bound to the transferrin receptor, which is recycled back to the cell surface, where it encounters the neutral pH environment of the blood.
The neutral pH causes the receptor to release the transferrin into the circulation, where it can pick up another Fe ion to repeat the cycle. The iron released in the endosome, like the LDL in Figure 15–33, moves on to lysosomes, from where it is transported into the cytosol. The system allows cells to take up iron efficiently even though the concentration of iron in the blood is extremely low. The iron bound to transferrin is concentrated at the cell surface by binding to transferrin receptors; it becomes further concentrated in clathrincoated pits, which collect the transferrin receptors.
In this way, transferrin cycles between the blood and endosomes, delivering the iron that cells need…...

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