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Bipolar Disorder Case Study

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Bipolar Disorder

Bipolar disorder is described as a mental disorder marked by alternating periods of elation and depression. An experiment concerning emotional reactivity in bipolar disorder has been conducted with the hypothesis stating that the depressive phase in bipolar patients could modify emotional reactivity in comparison to healthy subjects.
The methods used for this experiment include IAPS (International Affective Picture System) and SAM (Self-Assessment Manikin). IAPS is considered to be the most reliable and valid research paradigm to assess emotional responses in experiments concerning emotions. SAM is used for rating emotions and putting them on 1-9 scales. The participants chosen for this experiment were 23 bipolar patients with a major depressive episode without manic symptoms (13 females and 10 males), and 27 healthy control subjects (17 females and 10 males).
To begin the experiment, ninety color pictures were selected from IAPS that showed events with three varieties of valance, i.e., 30 pleasant events, 30 neutral events, and 30 unpleasant events. The emotional evaluation of pictures was rated on valance and arousal. The participants were instructed to rate how unpleasant or pleasant the image makes you feel using a 1-9 SAM valance scale, as well as rate how emotionally intense or arousing the image makes you feel using a 1-9 SAM arousal scale. The subjects were placed individually in a dimly lit room, and were seated in front of a 15-inch computer monitor.
The results of the experiment revealed that for all subjects, average valance ratings were significantly higher for pleasant photos than for neutral photos. Also, valance ratings were significantly higher for neutral photos than unpleasant photos. Another result includes that bipolar subjects rated neutral photos more negatively than the control group. Even so, there was no significant differences between the groups for unpleasant and pleasant photos. As for arousal ratings, the experiment showed the average ratings were significantly higher for the bipolar group compared to the control group. With this we can suggest that the patients have a different arousal for all pictures regardless of their valance.
In conclusion, the results have shown that patients in the depressive phase give a more negative valance to neutral images. This can be perceived as the patients being more pessimistic in the way they view the environment as being more reactive to the emotional cues. Even with IAPS being very reliable, there are other factors that should have been considered when conducting the experiment. For example, the amount of test subjects was not very high, so it is possible inaccurate results will occur taking into account how severe a subject’s symptoms might be. Also, more ways of measuring emotional response could have been done such as skin conductance and heart rate.
For the future, this experiment of emotional reactivity can greatly contribute to understanding the different phases of bipolar disorder. By figuring out what impairs regulation of emotions in all bipolar phases, treatment for bipolar disorder and identifying biomarkers to aid diagnosis would become much easier.

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