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Central Nervous System

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Generation of pattern and diversity in Central Nervous System

Central nervous system (CNS) is composed of brain and the spinal cord. Neurons constitute a major part of the developing CNS. An axon is an extension of a neuron. The brain grows as a swelling at the front (rostal) end of the neural tube and later leads to become a spinal cord (1,2). Development of the CNS involves many complex mechanisms beginning at the onset of transformation of a single layer of ectodermal cells, the neuroectoderm until the end of the differentiation process resulting into highly complex structure involving variety of neural cell types (1,2). A large number of cell types need to be arranged spatially and temporally to form a complex structure during an embryo development. CNS being one such complex structure formed during embryonic development involves many interlinked molecular mechanisms giving rise to interlinked and diversified neuronal circuits. Although a few of the signaling pathways (like shh) have been identified causing cellular diversity in a vertebrate CNS more studies have to be done to identify the involvements of any more of such signals. (1)

The nervous system (NS) develops from the ectoderm of a developing embryo. First to develop is the neural plate followed by formation of a neural groove in the neural plate very shortly. This is then followed by joining of the edges of the neural groove to form a neural tube, which later develops into the brain at the frontal part while the following part develops into the spinal cord. The left over cells on either side of neural tube midline form the neural crest cells, which constitute the peripheral nervous system. (1)

The vertebrate CNS originates from neural plate that in turn generates from dorsal ectoderm of gastrula- stage embryo. Neural plate closes to form the neural tube. The closure of neural tube gives rise to

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