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Cipla Portfolio

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CIPLA LTD.

Mahesh Bhalala
Roll no-3 UNDER GUIDANCE OF

DR. ANIL ANGRISH

NIPER

Company Discription
Founded in 1935, Cipla is the second largest pharmaceutical company in India with market share of 5.4% in FY10. Company offers various drugs and healthcare products with major share in many therapeutic categories & in most dosage forms. The company has well diversified product portfolio that includes OTC products, prescription products, flavors and fragrances, pesticides, and animal products. The Company's products are certified by various recognized regulatory authorities namely Food and Drug Administration (FDA), USA; Medicines and Healthcare products Regulatory Agency (MHRA), UK and like. The Company also provides technology services for preparation of product, product and process know how and new developments with various manufacturing facilities and R&D centers located across India. Company's business model is based on international strategic alliances by focusing on pursuing organic growth while reducing capital commitment and regulatory risks. In the US, Cipla has entered into partnership for 118 products with 22 partners. Number of partners has increased from 17 to 22 over the last 12 months. Of the pipeline of ~100 ANDAs filed till date, 57 have been approved (35 commercialized)while 45ANDAs are awaiting approval.In addition, Company has developed a strong presence in the 170 countries including both developed and developing countries and derived 55.4% of its FY10 revenues from exports to regions including US, Europe, Middle East,Africa andAustralia. In May 2007, Cipla overtook Ranbaxy and GlaxoSmithKline India (GSK) to become the largest pharmaceutical company in the domestic market. Recently in May 2010, it set up a wholly owned subsidiary, Cipla Singapore Pte. Ltd. In April 2010, it commenced commercial production of pharmaceutical formulations at its Special Economic Zone project at Indore, Madhya Pradesh.

Business overview
The present businesses of Cipla can be broadly classified into:  Domestic branded formulation sales.  Domestic unbranded formulation sales.  Exports.

Products: Cipla has the largest product basket among all the pharmaceutical players in India ranging from prescription to OTC to animal health, besides a big kitty for active pharmaceutical ingredients (APIs) or bulk drugs. In FY10, company has introduced approx. 200+ brands and expects to launch 120-150 new brands over FY11-12. Prescription: Amoebicides/Antiprotozoals, Anabolic steroids, Anaesthetics, Analgesics/Antipyretics, Antacids, Anthelmintics, Anti-inflammatory drugs,Anti-TB drugs, Antiacne drugs, Antiallergic drugs, Antialzheimer drugs, Antiasthma drugs, Antibiotics and Antibacterials Anticancer drugs etc. OTC: Cipla's over-the-counter drugs portfolio comprises the following: Analgesics – Oral, Artificial Sweetener, Calcium Preparations, Child Care, Cold & Flu, Constipation, Cosmetics & Skin Care, Dental Care & Oral Hygiene, Diarrhoea, Food Supplements, Indigestion, Infant Food, Medicated Plasters, Medicated Shampoos, Veterinary etc. Cipla's animal health care products division has four sections dedicated for equine, poultry, Companion animals, livestock animals products, apart from Herbal Specialities. Active Pharmaceutical Ingredients (Api): Cipla is one of the biggest exporters of low-cost, high quality APIs across the world. Major bulk drugs and intermediates manufactured by Cipla are: Adefovir Dipivoxyl, Albendazole USP, Albuterol Sulfate, Alendronate Sodium.3H2O, Alprazolam, Amlodipine Besylate, Anastrazole, Atorvastatin, Aripiprazole, Azelastine HCl etc. R&D Spend: Aggressive launch of new products - maintains domestic growth momentum Cipla's R&D division focuses on new product development and new drug delivery systems across a range of therapies. However, Cipla has relatively low profile on its R&D initiatives compared to the domestic peers, all of whom have set their sights on discovering new chemical entities (NCEs). But lately, R&D

spend of Cipla has been increasing and in FY10, the total R&D expenditure as a percentage of total turnover was ~ 5%.

Therapeutic Category ALIMENTARY T.& METABOLISM ANTINEOPLAST+IMMUNOMODUL BLOOD + B.FORMING ORGANS CARDIOVASCULAR SYSTEM CENTRAL NERVOUS SYSTEM DERMATOLOGICALS DIAGNOSTIC AGENTS G.U.SYSTEM & SEX HORMONES MUSCULO-SKELETAL SYSTEM PARASITOLOGY RESPIRATORY SYSTEM SENSORY ORGANS SYSTEMIC ANTI-INFECTIVES SYSTEMIC HORMONES VARIOUS Grand Total

Industry sales 105144.0441 3154.288091 17710.11637 45244.71794 29851.82886 23322.5752 505.645252 17281.19465 30665.09375 5943.618601 38377.49138 7015.176197 80889.74377 6449.448786 12254.22503 425250.1414

Company sales 1819.145532 350.633923 320.949345 2414.117209 630.328586 558.221474 10.545074 2188.217871 843.934971 381.472174 7035.073722 709.812616 5169.812868 5.014481 93.648545 22530.92839

Market Share 1.73 11.12 1.81 5.34 2.11 2.39 2.09 12.66 2.75 6.42 18.33 10.12 6.39 0.08 0.76 5.30

Count of BRAND 240 20 29 83 80 74 1 50 126 42 195 60 230 11 17 1258

 Wide Array Of New Products In Bouquet
 Aggressive launch of new products - maintains domestic growth momentum:  The total domestic drug market is valued at INR 40,052 crore, an increase of 17% over FY09, according to data from drug sales tracking agency, ORG-IMS. With the growth in domestic market Cipla domestic business grew at a CAGR of 13.5% during FY07-FY10 Cipla is one of the largest players in the domestic formulation market, with a market share of around 5% contributing 46% of the total turnover in FY2010. The company is the market leader in key therapeutic areas such as respiratory care, anti-viral and urological. Cipla's distribution network in India comprises a field force of around 5,100 employees and 42 exclusive and dedicated sales depots, as well as approximately 2,300 stockists and 160,000 chemists. During 2QFY11, domestic sales grew by 20% and in FY10, company has introduced approx. 200+ brands and expects to launch 120-150 new brands over FY11-12 contributing ~2-3% to sales. Cipla plans to focus on growing its market share and sales by increasing penetration in the Indian market, especially in the rural areas. It has plans to expand its product portfolio by launching biosimilars, particularly relating to the oncology, antiasthmatic and anti-arthritis categories. We expect Cipla will continue to derive its future growth from past introductions plus new brand launches in forthcoming years.  EU inhalers to lead growth:  Cipla has launched Salbutamol inhalers in the UK and received approvals for Budesonide inhalers in Germany and Portugal and Beclomethasone in Portugal. Ciplahas developed eight CFC-free inhalers for the EU region, of which six have been submitted for regulatory approvals. The company expects most of these registrations and compliances to be completed in two years. Launch of CFC-free inhalers in Europe and US with a potential market size of more than US $3 billion would be the long-term growth driver for the company. In addition, Cipla expected to launch the inhaler in

Russia and South Africa in 2HFY11. Management has also indicated that Inhaler sales contribution could increase to 25% of net sales over the next three years (from current 15% levels) if the regulatory approvals for EU come through.  Biosimilars launches in India:  Cipla has initiated investments in biotechnology in India and China. The company is setting up a factory to produce biosimilar activities and formulations at Goa. Through its joint venture in 3QFY10 with Desano, a Chinese company, CIPLA has initiated clinical trials and regulatory processes for the Indian markets and is currently working on six products. In biosimilars, the company is focusing on anticancer antiasthmatic and antiarthritis categories. Over the next three years, the company expects to invest up to USD 65 million in biosimilars, excluding any major additions in manufacturing capabilities. It plans to launch two products in the domestic market by FY2012.

 Contribution Of Top Therapeutic Category Therapeutic segment BRONCHODIL.INHALANT PREP. QUINOLONES AMPICILLIN/AMOXYCILLIN MUSCULO-SKELETAL SYSTEM ANTIPROGESTOGENS CEPHALOSPORINS HYPOTENSIVE COMB. BRONCHODILATORS SOLIDS DRUGS FOR BPH MACROLIDES AND SIMILAR ANTIVIRALS EX.VACCINES BETABLOCKERS STATINS ANTIHISTAMINES,SYSTEMIC ANTIPEPTIC ULCERANTS COUGH PREPARATIONS OTHER CYTOSTATICS ANTIINFECTIVES ANTIVIRALS CIPROFLOXACIN COMB. DIURETICS PLAIN ANTICOAGULANTS TRANQUILIZERS CALCIUM CHANNEL BLOCKERS ALL OTHER ANTIBIOTICS ANTHELMINTICS EX.SCHIS. APPETITE STIMULANTS %contribution 23.28% 7.28% 6.37% 3.97% 3.63% 3.08% 3.06% 3.01% 2.51% 2.15% 2.05% 1.98% 1.86% 1.83% 1.82% 1.77% 1.55% 1.43% 1.37% 1.29% 1.28% 1.18% 1.18% 0.87% 0.84% 0.74% 0.74% Therapeutic segment INHALER DEVICE CORTICOIDS,ANTIINF.COMB. VITAMIN B COMPLEX ORAL ANTIDIABETICS NORFLOXACIN COMB. GONADOTROPHINS ANTIFUNG. SYST. EX.GRIS. ANTIEMET.,ANTINAUS INJ. ANTIEMET.,ANTINAUS SOL. AMOEBICIDES TEAR SUBSTITUTE ANTIGLAUCOMA OTH.UROLOGICAL PREP. NASAL DECONGESTANTS OTHER CORONARY VASODILAT. ANGIOTENSIN RECEPTOR BLCK HORMO.CONTRACEP.NONTOP. DIURETIC COMBINATIONS DRUGS FOR SEXUAL DISORDER COLD PREPARATIONS ANTIACNE PREPARATIONS ANTIEPILEPTICS ANTIPARKINSON DRUGS ANTIDEPRESSANT,THYMONAL DRUGS FOR ALOPECIA OFLOXACIN COMB. ACE INHIBITORS %contribution 0.73% 0.65% 0.58% 0.57% 0.57% 0.55% 0.53% 0.51% 0.48% 0.47% 0.47% 0.46% 0.43% 0.42% 0.41% 0.39% 0.39% 0.38% 0.38% 0.37% 0.35% 0.34% 0.34% 0.29% 0.27% 0.26% 0.25%

 Contribution Of Top Brands Top Brands ASTHALIN SEROFLO NOVAMOX CIPLOX MT PILL FORACORT NORFLOX AMLOPRES-AT AEROCORT DUOLIN BUDECORT %contribution 5.44% 4.39% 3.86% 3.72% 3.43% 2.88% 2.25% 2.18% 2.18% 1.59% 1.58% Top Brands2 AEROCORT-OLD AZEE CIPLOX-TZ MISOPROST THEO ASTHALIN ATORLIP METOLAR EMESET CEFADUR OFLOX URIMAX %contribution3 1.46% 1.28% 1.27% 1.23% 1.22% 1.11% 1.08% 1.03% 1.02% 1.00% 0.98%

 GE Matrix

GE Matrix THERAPEUTIC SEGMENT ATTRACTIVENESS

HIGH

MEDIUM

LOW

HIGH

SYSTEMIC ANTI-INFECTIVES G.U.SYSTEM & SEX HORMONES DIAGNOSTIC AGENTS CARDIOVASCULAR SYSTEM

RESPIRATORY SYSTEM

BUSINESS STRENGTH

MEDIUM

ANTINEOPLAST+IMMUNOMODUL

BLOOD + B.FORMING ORGANS SENSORY ORGANS

LOW

SYSTEMIC HORMONES

ALIMENTARY T.& METABOLISM PARASITOLOGY CENTRAL NERVOUS SYSTEM

MUSCULO-SKELETAL SYSTEM DERMATOLOGICALS VARIOUS

 BCG Matrix

 There are very few molecules in new launch category (i.e. Question Mark(?)  So many molecules are in cash cow category.

 Concerns
 Adverse Currency movements  Cipla derives a major proportion of its revenues from overseas markets (more than 50% of total revenues) making it highly vulnerable to currency fluctuation risks, which may affect revenues significantly.  NPPA order for overpricing  NPPA (National Pharmaceutical Pricing Authority) has fined Cipla and some other pharmaceutical companies for overpricing which could result in cash outflow (INR 15 billion) and negative impact the profitability.  Strategic partnership model to sell its products in global market  The pharma industry is undergoing a major consolidation phase. The waves of mergers and acquisitions in the global generics market and the entry of many mid-size Indian pharma companies have created additional competition which might result in losing alliance with existing clients due to acquisition or merger of the clients with other companies.

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