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Clostridium Difficile

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Clostridium difficile
Jane Doe
A University

Clostridium difficile
Pathophysiology
Clostridium difficile is a gram positive, spore forming anaerobic bacillus, which may or may not carry the genes for toxin A-B production (Nipa, 2010). These two types of protein exotoxins produced by the Clostridium difficile bacillus, toxin A and toxin B, can have an infectious form and a non-active, non-infectious form (Grossman, 2010). The infectious form can survive for a short duration of time in the environment. The spores can survive for a longer period of time in the environment and are not infectious unless and until they are ingested or are transformed into an infectious state (Nipa, 2010). Together, the two toxins cause a large number of inflammatory mediators to descend on the colon, triggering more colitis and colonic ulcerations. Purulent debris then results, contributing to the development of a pseudomembrane. With the activation of the inflammatory response, the released mediators cause fluid secretion and increased permeability at the mucosal membrane and predispose the patient to diarrhea as well as drastic electrolyte and fluid shifts (Grossman, 2010).
Signs and Symptoms Symptoms caused by infection with Clostridium difficile range from mild diarrhea to profuse, watery diarrhea accompanied by severe inflammation of the intestine (Gould, 2010). Patient may complain of foul smelling diarrhea (Grossman, 2010). Symptoms may also include lower abdominal pain and systemic symptoms such as fever, anorexia and nausea; malaise may be seen. Gross bloody stools are uncommon but present with fecal occult blood (Nipa, 2010). Persons with more severe Clostridium difficile infection will have blood in their stools. They tend to have a fever, poor skin turgor, dry mucous membranes secondary to dehydration, and nausea (Grossman,

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