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Decreasing Low Grade Systemic Inflammation Through Exercise

In: Other Topics

Submitted By jonnybee
Words 2935
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Persistent low-grade inflammation has been identified as a significant contributor to the development of several chronic diseases, (Niklas et al, 2005) including heart disease and type II diabetes (Woods et al, 2009). Inflammation is indicated by an increased concentration of tumor necrosis factor (TNF), interleukin-6 (IL-6) and C-Reactive protein (CRP) in the bloodstream (Niklas et al, 2005). This elevation may be due to a number of factors, including increased visceral adipose tissue secreting cytokines (Niklas et al, 2005), decreased circulatory levels of interleukin-10 (IL-10), and elevated levels of pro-inflammatory cytokines. (4) This essays aims to show the role that exercise can play in reducing inflammation, and will examine this effect in an obese, type II diabetic population. This reduced inflammation will be looked at in terms of three different mechanisms; the first is a reduction of visceral fat from exercise, leading to a decrease in adipokine secretion, the second is the increased release of anti-inflammatory cytokines from skeletal muscle contraction, and the third is the release of adrenal hormones, leading to a release of anti-inflammatory catecholamines.
Inflammation can be acute or chronic and is indicated by a ‘two-to four-fold increase in circulating pro and anti-inflammatory cytokines’ (Woods et al, 2009) and by the presence of proteins such as CRP. The inflammation response can be due to trauma or as a result of factors such as obesity. Obesity can lead to persistent low-grade inflammation, as adipokines expand in visceral fat. This leads to an increase of the secretion of pro-inflammatory cytokines (e.g. IL-6 and TNF) and a decrease in anti-inflammatory molecules (e.g. IL-10 and Cortisol). Exercise has been shown to have the opposite effect to this, reducing the amount of pro-inflammatory cytokines in the blood.
Type II Diabetes, or

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