...immune T-helper cell type 2 (Th2) mediated response (Navarro et al. 2010; Allan & Devereux 2011). Dendritic cell persistence and activation of the adaptive immune response upon antigen detection are important in in the clearance of pathogens via this Th2 pathway. However, in an atopic asthmatic patient, the homeostatic equilibrium between this inflammatory Th2 mediated response and the T regulatory (Treg) cell response that dampen and suppress both effector...
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...Introduction: This research paper is about an emergent disease facing the world. Ebola has affected many countries in the world including United States of America. It has brought about many sociological factors that influenced the world to come together and work together and work together to fight the pandemic disease. United States and Britain come together raised money and funded my research institutions in America and in Africa to fight the disease. Therefore, I will take you into a journey and explain what Ebola is and how it is affected the world according to my research based on this disease. I hope you will learn how it affected the social factors in the society, for example, fatality rates and how the world society was affected in terms of health, financial constraints. This research paper is dedicated to the restless efforts of scientists, and government in the United States and Britain for their great contribution to fight Ebola. To the courageous doctors who flew to Africa and risked their lives in order to help the people in West Africa. Ebola virus disease (EVD) was also known as Ebola hemorrhagic fever, it is severe, often fatal illness in humans. It is transmitted from wild animals and spreads to human population via direct human transmission. For example, it can also be transmitted through body fluids, objects and fruits from primates Also, Ebola firstly appeared in Sudan, Nzara and in the Republic of Congo in a village near Ebola River...
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...Thesis Statement Writing Tuesday, Jun. 8th 2010 Before you familiarize yourself with thesis statement writing, you need to know what the statement is in the first place. This sentence basically sums up your main objective for writing the term paper, creates a simple guide for the reader and provides the basis for your argument. All in all thesis statement writing is quite simple, as long as you keep some tips and techniques in mind. The first thing you need to do is put together one question which is only possible if you compress the entire thesis. A great way to do this is examine the main topic and create a question out of it. It will give you a basic idea of what the statement should look like and how you should answer that question. The first sentence should introduce the topic and the objective and the next few should spell out how you plan to support your argument. Thesis statement writing, therefore, is about asking yourself the fundamental question that forms the essence of your paper. When you are done writing the statement, step back and examine in from another point of view to determine whether it is strong or weak. A strong statement is one which sparkles with confidence and focuses on one and only one aspect of the issue. This means that you can’t be vague or off-hand about the topic. If you have selected a theme, you should be ready to stand up for it- now is not the time to be diplomatic or meek. In addition to that, it should also spell out the basis for...
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...Or how will the person recover from the stroke? These are all questions that this paper will discuss. The information that follows will be in great details about a stroke, about our patient by the name of Stephanie. Stephanie has had a stroke. We want to ensure that Stephanie, our patient, understands what is next to come after her stroke. We will focus on the recovery process, the do's and do not's and the functions and limitations of a person who has had a stroke. What is a stroke? According to the American Heart Association, a "Stroke is a disease that affects the arteries leading to and within the brain. It is the number 5 cause of death and a leading cause of disability in the United States. A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot; it bursts or ruptures. When that happens, part of the brain cannot get the blood (and oxygen) it needs, so it and brain cells die" (American Heart Association, 2016.) When a person has a stoke it is unpredictable and affects the brain in a major way. When a person has a stroke, they can become paralyzed, lose memory and have to learn daily functions essential to living all over again with therapy. Cause and Effect When a person has a stroke and the brain is affected you have to dig deeper below the surface and conduct research and testing. A person is given an MRI (magnetic resonance imaging). This test will...
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...Epidemic Paper Ebola In the late 2014 and early 2015 there was this great outbreak of deadly Ebola in many countries in West Africa. The Ebola virus disease was formerly referred as Ebola hemorrhagic fever. The outbreak has happened in the past, but the recent one was a massive. It proclaimed much life that the west was a no-go zone due to fear of transmission. Due to the collaboration of many world health organizations and non-government organizations the epidemic was controlled and maintained. An epidemic disease is a disease that on outbreak it proclaims many lives in a short period of time before been controlled (Chowell et al. 2015). Ebola, as stated, is caused by a virus pathogen, it a virus is from Filoviridae family which include three main genera: Cuevavirus, Marburgvirus, and Ebolavirus. These are the main viruses responsible for the massive outbreak of Ebola last year in West Africa. For an extensive period of the spell, it is believed that the virus originated from infected animals and transmitted to human through food. Fruits bat of the Pteropodidae family is seen as the carrier of the Ebola virus. The virus was introduced into the human population through close contact with body fluids like blood, saliva, and sweat. From one human to the other the virus is transmitted via direct contact with bodily fluids or material, which had a contact with, infected people (Chowell et al. 2015). The virus is such a deadly to the extent that it resides even in dead bodies...
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...Tropical Regions of Africa and South America name University professor date Yellow Fever Yellow fever is a viral infection which is potentially fatal. Statistics kept by WHO, the World Health Organization, estimates that out of 200,000 cases of yellow fever each year, there are 30,000 deaths as a result of the infectious process (“Yellow Fever Fact,” 2010). Yellow Fever is endemic to tropical regions. The World Health Organization (WHO) reports that yellow fever is endemic to 30 sub-Saharan African countries and 13 Central and South American countries. In the 1900’s research discovered that yellow fever is transmitted by the Aedes aegypti mosquito and the development of a vaccine followed shortly after (Hill, 2009). Despite the development of a vaccine, today yellow fever is a serious health risk to the inhabitants of tropical South America, Africa, and to any travelers visiting these areas. This paper will discuss the infectious process of yellow fever, how yellow fever is diagnosed, and its’ signs and symptoms. Next, the pathophysiological changes caused by yellow fever will be explained. Lastly, available treatments and education to prevent yellow fever will be explored. Disease and Infectious Process The vector of the yellow fever virus is the Aedes aegypti mosquito. Meanwhile, humans and monkeys are the principle reservoirs for the virus. The process of infection starts with a female mosquito that feeds on an infected carrier of the yellow fever virus. The mosquito...
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...Abstract Since joint destruction begins within a few weeks of symptom onset in rheumatoid arthritis (RA), early diagnosis and treatment are crucial to decrease impairment of physical function and halt disease progression. A delay in therapy of as little as 3 months has demonstrated to cause irreversible joint damage. Treatment plans for RA includes pharmacological as well as non-pharmacological modalities. Treatments for rheumatoid arthritis (RA) have involved a variety of single agent and combination therapies with a goal, to slow disease progression and bone destruction. The research indicates that not all drug combinations are equally effective in all patients with RA. To more accurately distinguish how to best manage early RA, and because treating RA within 3 months of diagnosis appears crucial for improved outcomes, this paper review studies that compare combination to mono-therapies in RA. Introduction Rheumatoid Arthritis (RA) is considered to be an inflammatory arthritis (Gardner, 2010). It is a disease that is chronic and characterized by diffuse inflammation and degeneration of the connective tissues, often characterized by joint stiffness in the morning that lasts at least 30 minutes but can range to several hours (Gardner, 2010). Pain improves with activity as fluid accumulated in the joints during inactivity is forced back into the system through the lymphatics. RA has a different cause from Osteoarthritis (OA). It is considered to be...
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...Edwin Hill Professor Skolnik English 1280-05 Final Research Paper HIV: Introspective Overview What is HIV? Figure 1 HIV 1 virus electron micrograph, (Goldsmith) Human immunodeficiency virus (HIV) is a retrovirus of the lentivirus genus. HIV attacks the immune system by invading and destroying certain white blood cells such as helper T cells (mainly CD4+ T cells), dendritic cells, and macrophages. The infection and destruction of the CD4+ T cells takes place through three methods: The direct viral killing of the infected cells, the apoptosis (programmed cell death) of infected cells, and the killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. Once the CD4+ T cells are diminished to a certain critical level, the immunity catalyzed and mediated by these cells is lost, leaving the body vulnerable to infection from other viruses (Noble, AVERT). The last stage of HIV infection is AIDS (acquired immunodeficiency syndrome). This stage is reached due to lack of treatment while in the earlier stage of HIV. Those who reach this stage commonly die due to infections associated with the progressive failure of the immune system. There are two known types of HIV: HIV-1 and HIV-2. Both are transmitted by either sexual contact, through blood, or from mother to child, and they both appear to cause clinically indistinguishable AIDS. However, HIV-2 is less easily transmitted, and the period between initial infection...
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...of Neuroscience, March 24, 2010 • 30(12):4467– 4480 • 4467 Development/Plasticity/Repair Demonstration of a Neural Circuit Critical for Imprinting Behavior in Chicks Tomoharu Nakamori,1,3 Katsushige Sato,2,4 Yasuro Atoji,5 Tomoyuki Kanamatsu,6 Kohichi Tanaka,1 and Hiroko Ohki-Hamazaki1,3,7 1 Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute and 2Department of Physiology and Cell Biology, Faculty of Medicine, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan, 3Division of Biology, College of Liberal Arts and Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan, 4Department of Health and Nutrition Sciences, Faculty of Human Health, Komazawa Women’s University, Inagi-shi, Tokyo 206-8511, Japan, 5Laboratory of Veterinary Anatomy, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan, 6Department of Environmental Engineering for Symbiosis, Faculty of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan, and 7Recognition and Formation, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan Imprinting behavior in birds is elicited by visual and/or auditory cues. It has been demonstrated previously that visual cues are recognized and processed in the visual Wulst (VW), and imprinting memory is stored in the intermediate medial mesopallium (IMM) of the telencephalon...
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...[pic] HIV/AIDS INFECTION: A THREATHENING VIRAL DISEASE By Raymond G. Cervantes John Rey Hesita March, 2010 Mr. Armando Torrente Professor OUTLINE I. Introduction-------------------------------------------------------------------------------------------1 A. Background of the Research-------------------------------------------------------------------------1 B. Statement of the Problem------------------------------------------------------------------ ----------3 C. Importance of the Paper------------------------------------------------------------------------------3 D. Definition of Terms ----------------------------------------------------------------------------------3 II. Body----------------------------------------------------------------------------------------------------5 A.Modes of Transmission of HIV/Aids (Direct Factors) ----------------------------------------5 1.Sexual Transmission-----------------------------------------------------------------------------------5 2,Mother to Child Transmission------------------------------------------------------------------------5 3.Transmission via Fomites-----------------------------------------------------------------------------5 4. Needles--------------------------------------------------------------------------------------------------5 5. Blood Traces--------------------------------------------------------------------------------------------6 6. Routine Medical...
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...Travis Block Dominic Marino BME 262 – Cell and Tissue Engineering Professor Hani Awad Cellular Therapy for the Treatment of Moderate to Severe Traumatic Brain Injury Introduction: Traumatic brain injuries occur when external forces cause traumatic injury to the brain. They directly affect 1.5 million Americans annually, and annually result in 100,000 cases of life-long impairment with substantial loss of function. Today there are 3.2 million Americans living with long-term disability as a result of brain injury (Congressional Brain Injury Task Force, 2012). It is estimated that 2.5 to 6.5 million individuals live with consequences of TBI (National Institue of Health). In addition to the devastating effects on the families and friends of those injured due to cognitive, social, emotional, and behavioral effects; TBIs are also responsible for significant economic cost to society. Annual societal economic impact of TBIs has been estimated at $60 billion. This cost accounts for 29% of the total cost of all injuries in the United States (Max, MacKenzie, & Rice, 1991). Even though the NIH considers the burden of disease when allocating funding, acute treatments for TBI are still limited to attempting to control intracranial pressure and optimizing cerebral perfusion to prevent further edema, inflammation and cell death, and chronic treatment is limited to motor, cognitive, and behavioral rehabilitation (Varmus, 1999). While these treatments are limited...
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...1 A Critical Evaluation of the Use of Neonicotinoid Insecticides on Human Health Jess A. White School of Health, University of Northampton (2015). Insecticides are universally used, not just by farmers, but by household gardener’s as a way to prevent, mitigate or repel pests. Due to outbreaks of infectious disease in honey bees and amphibians, the use of systematic insecticides has significantly increased over the last 20 years (Mason et al., 2012). And is now thought to be the preferred choice; because of their toxicity and mechanistic action. One type, in particular, seen to show a usage increase is – neonicotinoids - a class of agrochemicals derived from nicotine (a substance found in cigarettes). It is thought this derivative form is solely based on the chemical similarity of the two (Calderon-Segura et al., 2012). First introduced within the 1990’s, neonicotinoids were principally used for their systematic nature. While most insecticides are placed on the surfaces of yielding crops, neonicotinoids are taken up by the roots and translocated to separate areas. This, therefore, makes the plant toxic to certain insect species (Pisa et al., 2014). It is this mechanism of action that has now simultaneously been linked to the adverse impacts on several other invertebrate and vertebrate species (Sluijs et al., 2014). There are currently, five authorised neonicotinoid insecticides available for use in the UK, including (1) acetamiprid, (2) clothianidin, (3)...
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...Review Paper Inulin - a versatile polysaccharide with multiple pharmaceutical and food chemical uses. Thomas Barclaya, Milena Ginic-Markovica, Peter Cooperb,c, Nikolai Petrovskyc,d a Flinders University, Adelaide, Australia 5042 Cancer Research Laboratory, ANU Medical School at the Canberra Hospital, Australian National University, Canberra, Australia 2605 c Vaxine Pty Ltd, Flinders Medical Centre, Adelaide Australia 5042 d Department of Endocrinology, Flinders Medical Centre, Adelaide, Australia 5042 b Received: 27 August 2010 Accepted: 10 October 2010 ABSTRACT á-D-glucopyranosyl-[â-D-fructofuranosyl](n-1)-D-fructofuranoside, commonly referred to as inulin, is a natural plant-derived polysaccharide with a diverse range of food and pharmaceutical applications. It is used by the food industry as a soluble dietary fibre and fat or sugar replacement, and in the pharmaceutical industry as a stabiliser and excipient. It can also be used as a precursor in the synthesis of a wide range of compounds. New uses for inulin are constantly being discovered, with recent research into its use for slow-release drug delivery. Inulin, when in a particulate form, possesses anti-cancer and immune enhancing properties. Given its increasing importance to industry, this review explains how inulin's unique physico-chemical properties bestow it with many useful pharmaceutical applications. KEY WORDS: Inulin, polysaccharide, fructose, excipient, vaccine, adjuvant INTRODUCTION ...
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...of Materials Cranfield University, United Kingdom the aim of this book series is to disseminate the latest developments in small scale technologies with a particular emphasis on accessible and practical content. these books will appeal to engineers from industry, academia and government sectors. for more information about the book series and new book proposals please contact the publisher, Dr. Nigel hollingworth at nhollingworth@williamandrew.com. http://www.williamandrew.com/MNt NaNotechNology applicatioNs for cleaN Water edited by Nora savage Office of Research and Development, US Environmental Protection Agency and (in alphabetical order) Mamadou Diallo Materials and process simulation center, Division of chemistry and chemical engineering, california institute of technology Jeremiah Duncan Nanoscale Science and Engineering Center, University of Wisconsin-Madison anita street Office of Research and Development, US Environmental Protection Agency and Center of Advanced Materials for the Purification of Water with Systems, University of Illinois at Urbana-Champaign richard sustich N o r w i c h , N Y, U S A copyright © 2009 by William andrew inc. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. ISBN: 978-0-8155-1578-4 Library of Congress Cataloging-in-Publication...
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...From www.bloodjournal.org by guest on March 10, 2015. For personal use only. How I treat How I treat enteropathy-associated T-cell lymphoma Antonio Di Sabatino,1 Federico Biagi,1 Paolo G. Gobbi,1 and Gino R. Corazza1 1First Department of Medicine, Centro per lo Studio e la Cura della Malattia Celiaca, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, University of Pavia, Pavia, Italy Enteropathy-associated T-cell lymphoma (EATL) is a complication of celiac disease (CD). This tumor derives from the neoplastic transformation of aberrant intraepithelial T lymphocytes emerging in celiac patients unresponsive to a gluten-free diet. Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD. Recurrence of diarrhea, unexplained weight loss, abdominal pain, fever, and night sweating should alert physicians to this complication. The suspicion of EATL should lead to an extensive diagnostic workup in which magnetic resonance enteroclysis, positron emission tomography scan, and histologic identification of lesions represent the best options. Treatment includes high-dose chemotherapy preceded by surgical resection and followed by autologous stem cell transplantation, although biologic therapies seem to be promising. Strict adherence to a gluten-free diet remains the only way to prevent EATL. (Blood. 2012;119(11): 2458-2468) Introduction Celiac disease (CD) is a chronic...
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