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Desert Hedgehog Research Paper

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The desert hedgehog gene is a key gene to the human reproductive system. It plays a vital role in the development of important sexual organs. Along with the other hedgehog proteins, the hedgehog protein family and signaling pathway are also important to the overall development of many parts and systems of the human body. Each protein within the family has its own role to play in overall expression of cells and growth. There are a total of three proteins within the family; the Indian hedgehog (IHH), the sonic hedgehog (SHH), and the desert hedgehog (DHH) gene. The term hedgehog refers to the terminal domains within the genes of this family. The “hog” domain makes up the C-terminal of the gene and the “hedge” domain makes up the N-terminal of …show more content…
They are separated into two similar sized globular fragments during an auto-cleavage reaction creating that create HhN and HhC globular fragments. (1) The “hedge” and “hog” domains are both highly conserved. With the addition of a cholesterol moiety and signaling sequence, one before the auto-cleavage and one after, the HhN and HhC peptides are formed within the endoplasmic reticulum. (1) The development of the nervous and skeletal systems is assisted by the sonic hedgehog gene (Shh). The Ihh, or Indian hedgehog gene, aids in such functions as bone formation and the desert hedgehog gene, (Dhh), helps in the formation of the peripheral neurvous system, differentiation of myoid cells and formation of the testis cord. (1) In this paper we will explore more about the desert hedgehog gene and important research surrounding this gene with the intent to show that the desert hedgehog gene is not only important to the growth of the reproductive system and its sexual organs, but to the whole

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