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Diabetic

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Diabetic Mellitus –Type 2

Reason of admission-Chief Complaint: A 55-year-old Caucasian man presented with polyuria, polydipsia, and "feeling dry" during the past 2 months.
History of Present Illness: Physical examination revealed a height of 5'11", weight of 240 lb (body mass index [BMI] of 34.4 kg/m2), blood pressure of 150/88 mm Hg, and pulse of 80/min. There was no abdominal tenderness or organomegally. Laboratory evaluation showed a serum glucose of 397 mg/dl. Urinalysis revealed 3+ glucose and negative ketones.
His medical history was remarkable for a 3-year history of poorly controlled hypertriglyceridemia. His initial fasting serum cholesterol was 299 mg/dl, triglycerides were 928 mg/dl, and high-density lipoprotein (HDL) cholesterol was 30 mg/dl before treatment.
Past medical history: He was treated with gemfibrozil (Lopid) 600 mg twice daily and told to watch his diet and exercise. No referral was made to a registered dietitian.
Current medications:
A fasting triglyceride level of 570 mg/dl prompted further increase of gemfibrozil to 600 mg three times daily (this exceeds usual recommended dosing). The patient was started on 5 mg glyburide [Micronase] daily. He was also given a referral to a dietitian. That evening, the patient complained of abdominal pain, nausea, vomiting and flu-like symptoms. He collapsed at home and died a short time later. At autopsy, it was found that he died of acute hemorrhagic pancreatitis. The patient was also found to have severe arteriosclerotic cardiovascular disease with severe two-vessel coronary artery atherosclerosis.
Social History:The patient took no other medications and don’t drink alcohol and smoke.
Plan:Hypertriglyceridemia can be primary (associated with familial hypertriglyceridemia) or secondary (due to diabetes mellitus, hypothyroidism, kidney disease, or medication). Important exacerbating factors are obesity and excess alcohol intake.
In type 2 diabetes, a common abnormal lipid pattern is an elevation of very-low-density lipoprotein (VLDL) cholesterol, a reduction in HDL, and a low-density lipoprotein (LDL) cholesterol that contains a greater proportion of small, dense atherogenic LDL particles.3 Diabetes, as a possible cause of the hypertriglyceridemia, should be evaluated and treated if found, as several studies have shown that this pattern of dyslipidemia precedes the onset of type 2 diabetes mellitus.4
People with triglycerides 500 mg/dl are at risk of pancreatitis. This risk increases as triglycerides increase, becoming very high when serum triglycerides approach 2,000 mg/dl.5 Special immediate attention to lower triglycerides to

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