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Disorders of the Lymphatic System

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Disorders and Diseases affecting the Lymphatic System
Non-Hodgkin’s Lymphoma

Non-Hodgkin lymphoma (NHL) is the most commonly occurring blood related malignancy effecting the lymphatic system. It is the sixth leading cause of cancer death in the United States, and its incidence is on the rise, since the early 1970's, incidence rates for NHL have nearly doubled. Of the nearly 500,000 Americans with lymphoma, approximately 332,000 have this form. Over 65,000 cases of NHL are diagnosed annually in the United States. (www.LYMPHOMA. Org 2015, n.d.)
Lymphoma occurs when lymphocytes, a type of white blood cell, grow abnormally. The body has two main types of lymphocytes that can develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Cancerous lymphocytes can travel to many parts of the body, including the lymph nodes, spleen, bone marrow, blood or other organs, and can accumulate to form tumors. The two main forms of lymphoma are Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Non-Hodgkin lymphoma is not a single disease, but a group of several closely related cancers. The World Health Organization estimates that there are at least 61 types of NHL. (www.LYMPHOMA. Org 2015, n.d.)
Non-Hodgkin lymphomas are broadly divided into two major groups: B-cell lymphomas and T-cell lymphomas. B-cell lymphomas develop from abnormal B-lymphocytes and account for 85 percent of all NHLs. T-cell lymphomas develop from abnormal T-lymphocytes and account for the remaining 15 percent of all NHLs. Non-Hodgkin lymphomas may also be classified as indolent (slow-growing) or aggressive (fast-growing). (King, (2014). )

Although the various types of NHL have some things in common, they differ in their appearance under the microscope, their molecular features, their growth patterns, their impact on the body and how they are treated. Treatment...

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