...Multiple sclerosis (MS) is a central nervous system disease in which the immune system attacks its own cells. It affects between 250,000 to 350,000 people in the United States. It can cause inflammation and damage to the tissues that surround the brain leading to dysfunctional nerve impulses (Curtin et al., “Clinical Development” 265; Goldenberg 175; “White Matter Matters”). The symptoms of MS include loss of body movements, some visual loss, and numbness and tingling and about 50% of patients will require assistance with walking within 15 years after disease onset (Goldenberg 175). Multiple sclerosis is also considered to be a CD4+ T-cell-mediated disease because in previous animal experiments, CD4+ T cells were able to produce a disease similar...
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...V. Racaniello page 1 Viral Pathogenesis This lecture will define and discuss the basic principles of viral pathogenesis, the entire process by which viruses cause disease. Viral disease is a sum of the effects on the host of virus replication and of the immune response. Interest in viral pathogenesis stems from the desire to treat or eliminate viral diseases that affect humans. This goal is achieved in part by identifying the viral and host genes that influence the production of disease. Progress in understanding the molecular basis of viral pathogenesis comes largely from studies of animal models. The mouse has become a particularly fruitful host for studying viral pathogenesis because the genome of this animal can be manipulated readily. In some cases, non-human hosts can be infected with the same viruses that infect humans, but close relatives of human viruses must often be used. Viral Entry Three requirements must be satisfied to ensure successful infection in an individual host: • Sufficient virus must be available to initiate infection • Cells at the site of infection must be accessible, susceptible, and permissive for the virus • Local host anti-viral defense systems must be absent or initially ineffective. To infect its host, a virus must first enter cells at a body surface. Common sites of entry include the mucosal linings of the respiratory, alimentary, and urogenital tracts, the outer surface of the eye (conjunctival membranes or cornea), and the skin (Fig. 1). Figure...
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...Although Toxoplasma gondii is not a major food-borne pathogen, but it is crucial from the public health viewpoint (Batz et al., 2011). Also, despite the initial concern that T. gondii is related to dealing with cats and cat’s litter, fifty percent of toxoplasmosis cases are food-borne (Slifko et al., 2000; Scallanet al., 2011). The main routes for transmission of T. gondii to human are ingestion of the environmentally resistant sporulated oocysts, or eating raw or undercooked meat containing the cysts or pseudocysts (Dubey, 1998b). There are other routes of transmission as Transplacental infection in congenital transmission (Jones et al., 2001) and organ transplantation. Rarely, via blood transfusion or handling infected blood by laboratory workers (Tenter et al.,...
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...Changes in climate relate to changes in surrondings and often , as an example, temperature, precipitation, and wind over the course of months to several years. More widely, climate refers to changes in atmosphere (gaseous envelope surrounding the earth), layer (water on the surface of the earth), cryosphere (snow, ice, and land on and below the surface of the world and ocean), land surface, and region (ecosystems and organisms living within the atmosphere, land, and oceans).When we point out temperature change, we tend to accept its effects on our surroundings like melting polarice caps, extreme swings in weather, additional frequent droughts, flooding, and incidences of natural disasters. When we rely on climatic changes, mental state may...
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...Microbiology Biology 299 9/18/2015 West Nile Virus The height of the summer months brings high temperatures in late afternoons. We are all smacking, swatting and spraying - knowing it’s that time of year for mosquitoes. Mosquito bites are a nuisance. Many people fear contracting the West Nile Virus. A virus is described as “a genetic element that contains either RNA or DNA and that replicate only in host cells; has an extracellular form.” (Brock Biology of Microorganism’s) A virus is also an ultramicroscopic infectious agent which replicates itself only within cells of living hosts. (Webster Dictionary) Along with being classified as a virus West Nile shows that it only infects certain and specific cells [Secondary Source]. Since Dmitri Ivanovsky's 1892 article describes a non-bacterial pathogen infecting tobacco plants, and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, about 5,000 viruses have been described in detail. [Secondary Source] Although there are millions of different types, viruses also undergo cycles in order to reproduce and harm and/or help organisms. There are two types of viral cycles known to men, the lytic cycle and the lysogenic cycle. In the lytic cycle the virus attaches itself to the host cell and nucleic acid is inserted into the cell. Next it makes copies of DNA and capsid and more viruses are assembled. Finally the viruses are released by bursting the cell and destroying it. The lysogenic cycle is slightly different...
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...GENETICS CASE STUDY GENETICS CASE STUDY This case study is based on a high-risk pregnancy due to advanced maternal age, genetic test indicating the fetus to have Tay-Sachs Disease and the coping strategies for this family. Rita Trosack is a 43-year old white female, married for six years to husband, Peter, a 46-year old white male. They both work in the financial district of Chicago and live downtown. They have been trying to conceive for two years. They both work an average of sixty hours a week. Rita and Peter were both raised as Catholics; however, they choose not to practice at this time. Rita missed her menstrual period, began having typical signs and symptoms of pregnancy (nausea, dry heaving, tender breasts, and fatigue). The fatigue was so severe she decreased her hours at the bank. An early pregnancy test performed by Rita tested positive. She then calculated her due date as January 27, 2009, since her last menstrual period (LMP) began on April 20, 2008. Rita met with Dr. Zimmerly an obstetrician in a high-risk obstetric clinic. On this first visit he confirmed the estimated date of delivery (EDD) as late January 2009. Due to Rita’s age, the chorionic villus sampling (CVS) was recommended to screen for fetal genetic defects. Rita had the test in early July, which would place her around eleven weeks into her pregnancy; this is the appropriate time in which to perform the CVS. Amniocentesis could have been performed, but this is usually...
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...geriatric medicine. As a physician you will be faced daily with the concepts of microbial disease and antimicrobial therapy. Microbiology is one of the few courses where much of the "minutia" is regularly used by the practicing physician. This book attempts to facilitate the learning of microbiology by presenting the information in a clear and entertaining manner brimming with memory aids. Our approach has been to: 4) Create a conceptual, organized approach to the organisms studied so the student relies less on memory and more on logical pathophysiology. The text has been updated to include current information on rapidly developing topics, such as HIV and AIDS (vaccine efforts and all the new anti-HIV medications), Ebola virus, Hantavirus, E. coli outbreaks, Mad Cow Disease, and brand-new antimicrobial antibiotics. The mnemonics and cartoons in this book do not intend disrespect for any particular patient population or racial or ethnic group but are solely presented as memory devices to assist in the learning of a complex and important medical subject. We welcome suggestions for future editions. 1) Write in a conversational style for rapid assimilation. 2) Include numerous figures serving as "visual memory tools" and summary charts at the end of each chapter. These can be used for "cram sessions" after the concepts have been studied in the text. 3) Concentrate more on clinical and infectious disease issues that are both interesting and vital to the actual practice of medicine. MARK...
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...cell multiplication mechanism. AIDS A-Acquired an acquired condition is the one that is not inborn. AIDS patient acquire a condition that makes them not able to fight infections. I - Immune A normal human being has an immune system that helps them fight disease. The immune system involves structures such as the skin to keep away entry bacteria and other pathogens. The environment we live is full of micro organisms some living in the air, others water and others in food. Our bodies are well adopted to keep away these micro organisms. D – Deficiency. When it comes to HIV AIDS there is deficiency of adequate immunity. HIV virus infect immune cell (to be particular T-helper or CD4+ cells). T - Helper cells are very instrumental in the immune system thus when they are attacked by the virus they deplete in number. S - Syndrome: A variety of different symptoms and illness. The grouping of well recognized illness connected with AIDS makes a syndrome. TYPES OF HIV Two types of HIV are currently recognized: HIV-1, HIV-2. - Transmission of both of virus is by sexual contact, through blood and from mother to child. - They cause the same clinical symptoms. HIV – 1 - It is the most predominant virus. - It is responsible for the many cases of AIDS in the US, Europe and Africa. 1 - It is divided further into subtypes; - These subtypes are named A – J. - These subtypes are unevenly distributed throughout the world....
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...(Mashpedia.com) Tourette syndrome (TS) is easily misunderstood and as a society we scrutinize these people for having bad behaviors or parents for not being able to control their children. Tourette’s can impact a person/family’s life socially and emotionally because of the misconceptions of Tourette’s. With the first symptoms of TS appearing in early childhood, they become more apparent closer to adolescences and TS can be a chronic lifelong condition with no cure, with progressing symptoms appearing in their early teens. Tics show signs of improving by mid-teens to early adulthood for the majority of individuals with TS, and for the lucky few who can actually become symptom free. The risk factors and cause of TS is unknown, though genetic studies have shown that TS is an inherited dominant gene with a fifty percent chance of a parent passing the gene onto their child. TS can be...
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...“Evolution’s a bitch” –Wiley “Suckers are good to eat” –Wiley WHAT HAS EVOLUTION DONE FOR ME What has evolution done for me • Agricultural crops and animal breeding for the past 8,000 years • With the discovery of methods to reconstruct evolutionary relationships there is been a vast increase in the relevance of evolutionary biology to human society. Reconstructing Phylogenies • 1859-1950- No coherent empirical methods • 1950-1966- Emergence of Phylogenetic Systematics • Phylogeny by discovery of the order of evolutionary innovation Ribotyping • Fingerprinting or sequencing RNA • Many diseases have unknown causes • However, diseased tissues can be ribotyped. (Wiley Death Fish) • This process involves extracting DNA from diseased tissues and then sequencing the DNA that codes for rRNA. • If a disease agent such as a bacteria is present, then we will get ribosomal DNA sequences from the host (you) and the bacteria (the infection agent). Ribotyping: Phylogeny matching • Once we have the rDNA sequences, we can plug them into a sequence matrix of all life and see where our unknowns appear on the tree of life. Our Food Chain • Some products are easy to identify, but others are not. • A slab of fish fillet from a sea bass looks like a slab of sih fillet from a farmed Asian catfish. • But the sea bass costs $10/pound while the Asian catfish costs $4/pound. • Yet, a simple phylogenetic analysis can...
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...General Information Read and translate the following definitions: Medicine: Science of diagnosing, treating, and preventing disease. The word also refers to any drug used to treat an illness or injury. Physician or Doctor: Person trained and licensed to practice medicine; one who treats the entire body is a general practitioner (G.P.) . Surgery: medical specialty of cutting into, or performing operative procedures on the patient. A doctor who does this is a surgeon. Acupuncture: Method of curing illness or relieving pain by inserting needles into the body at certain points; originally developed by the Chinese. Epidemic: Contagious disease which spreads rapidly throughout large portions of the population. The bubonic plague is a famous example of an epidemic which ravaged Europe in the Middle Ages. Modem medical science has found means of preventing most epidemics. Skeleton: Bony framework of the body, including the spinal column, the rib cage, the skull, and the bones of the arms and legs. Anatomy: Science of the structure of organisms, including the human body; can be studied by dissecting, or cutting into organisms. Pharmacy: Store where medicines are sold, especially by prescription; also known as a drugstore or an apothecary. Licensed pharmacists prepare medications, selling certain 3 drugs only when they are prescribed by a physician. Disease: Pathological condition which causes abnormal body functions and presents certain symptoms or signs; can be caused by a ...
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...Table of Contents 2. Biomedical and Electronic skin patch 2 Motivation behind the Technology 5 Applications 6 Drug delivery system 6 Health monitoring 8 Medium of Communication 11 Human Computer Interaction Interface 12 Stakeholders 12 3. Ethical and Legal Concerns with the technology 14 3.1 Legal Issues 14 Inconsistent Medication 14 Number of Impacts of Wireless Technology 15 Data Integrity and Hacking 16 3.2 Ethical dilemma 17 Cultural and religious criticism 17 Public Monitoring/privacy 19 Impact on people with disabilities 20 Cost issues 20 Social Issues/implications 20 Credibility of Source of Information 21 4. Resolutions for these dilemmas 22 4.1 Possible solution 22 Tackling health issues 22 Preventing leakage of personal information 23 Preventing Overuse of Skin Patch 24 Addressing cultural issues 24 Denying any form of tracking human information 25 4.2 Strategy for implementation 25 Conclusion 26 Reference List 26 1. Introduction The purpose of this report is to identify the legal and ethical issues related to electronic skin patch and provide a possible solution to tackle it. The limitations of current medical science lead to the advancement of biomedical science to resolve the gap. The report further deals with the new technology electronic skin patch that promises to overcome the potholes of the traditional medical science. It provides the detailed analysis of the technology and the strategy...
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...Occupational Health Q1.( A) Define Health Hazards. Explain the processes that can be hazardous for the health of workers with examples. ANS. Health hazard is the state of events which has the potential to threaten and / or adversely affect health of the exposed employees. Or A danger to health resulting from exposure to environmental pollutants, such as asbestos or ionizing radiation, or to a life-style choice, such as cigarette smoking or chemical abuse. Health hazards may be classified as below 1. Chemical 2. Physical 3. Mechanical 4. Biological 5. Psychosocial Above mentioned hazards as well as all other health hazards are disastrous due to their adverse effects on exposed people like Bodily injury, Disease, Change in the way the body functions, grows, or develops, Effects on a developing fetus (teratogenic effects, fetotoxic effects), Effects on children, grandchildren, etc. (inheritable genetic effects) Decrease in life span, Change in mental condition resulting from stress, traumatic experiences, exposure to solvents. Effects on the ability to accommodate additional stress Following are some processes that can be hazardous for the health of workers 1. Abrasive blasting; abrasive blasting operations can create high levels of dust and noise. Abrasive material and the surface being blasted may contain toxic materials (e.g., lead paint, silica) that are hazardous to workers. Silica sand (crystalline) can cause silicosis...
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...4 Main Idea • • • • • What is a main idea? What is a topic? How do you recognize the difference between general and specific ideas? What is a stated main idea? What is an unstated main idea? Everyday Reading Skills: Selecting a Book Copyright ©2010 by Pearson Education, Inc. 118 CHAPTER 4 Main Idea What Is a Main Idea? The main idea of a passage is the core of the material, the particular point the author is trying to convey. The main idea of a passage can be stated in one sentence that condenses specific ideas or details in the passage into a general, allinclusive statement of the author’s message. In classroom discussions, all of the following words are sometimes used to help students understand the meaning of the main idea. thesis main point central focus gist controlling idea central thought Whether you read a single paragraph, a chapter, or an entire book, many experts agree that your most important single task is to understand the main idea of what you read. Topic Main Idea Major Detail Major Detail Major Detail Minor Detail Minor Detail Minor Detail Minor Detail Minor Detail Recognize General and Specific Words The first step in determining the main idea of a selection is to look at the specific ideas presented in the sentences and try to decide on a general topic or subject under which you can group these ideas. Before tackling sentences, begin with words. Pretend that the sentence ideas in a selection have been reduced...
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...Section A: Basic Microbiology 1 SCOPE AND HISTORICAL DEVELOPMENTS IN MICROBIOLOGY “Science contributes to our culture in many ways, as a creative intellectual activity in its own right, as a light which has served to illuminate man’s place in the uni-verse, and as the source of understanding of man’s own nature” —John F. Kennedy (1917–63) The President of America The bacterium Escherichia coli INTRODUCTION AND SCOPE MICROBIOLOGY is a specialized area of biology (Gr. bios-life+ logos-to study) that concerns with the study of microbes ordinarily too small to be seen without magnification. Microorganisms are microscopic (Gr. mikros-small+ scopein-to see) and independently living cells that, like humans, live in communities. Microorganisms include a large and diverse group of microscopic organisms that exist as single cell or cell clusters (e.g., bacteria, archaea, fungi, algae, protozoa and helminths) and the viruses, which are microscopic but not cellular. While bacteria and archaea are classed as prokaryotes (Gr. pro-before+ karyon-nucleus) the fungi, algae, protozoa and helminths are eukaryotes (Gr. eu-true or good+ karyon-nucleus). Microorganisms are present everywhere on earth, which includes humans, animals, plants and other living creatures, soil,water and atmosphere. Microorganisms are relevant to all of our lives in a multitude of ways. Sometimes, the influence of microorganisms on human life is beneficial, whereas at other times, it is detrimental. For example...
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