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Epigenetic Summary

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The field of epigenetics allows us to get a better understanding of the effects of stress and how it can have a prolonged impact on gene activity. Many studies(N.A Hazel et al., 2005, V.J. Felitti 2002, Franklin et al., 2010) carried out on humans and animals have shown that even early life stress can lead to epigenetic changes which can affect us in adulthood. These changes can make us more susceptible to many neuropsychiatric and cardiovascular disorders. In a study carried out by Nätt et al., 2015 the epigenetic mechanisms caused by high stress levels were studied in children. They measured the levels of cortisol in children’s hair (assuming that stress levels were correlated with cortisol levels), according to this the children were divided into high and low stress groups. …show more content…
They used a “rat model of infant maltreatment by a caregiver”, to investigate whether “early-life adversity leaves lasting epigenetic marks at the Brain-derived Neurotrophic Factor (BDNF) gene” in the central nervous system. They examined DNA methylation patterns and gene expression in the rats that experienced maltreatment and in their offspring and concluded that the changes in methylation due to stress that they were investigating can be passed onto future generations. Could this research provide an explanation on how we inherit disorders such as depression? Depression is also a stress-related disease (Hammen, 2005) and has a heritability rate of 31-42% (Sullivan et al,. 2000) It has been estimated that around 350 million people (of all ages) suffer from depression today, it is the most common mental disorder in the world. Due to the enormity of this problem it is important to study how depression can be passed on to children and what exactly causes it, in order to come up with medication that will be able to cure or prevent it, I believe that epigenetics could be the key for discovering answers to many of these

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