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Fatigue Case Study Essay

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Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.

The occurrence of fatigue in an adult is about 27% and one third of that try to find medical treatment. Research is showing that oral administration of vitamin C is less effective because of low bioavailability of vitamin C in plasma. The lack of randomized controlled experiments to evaluate the usefulness of intravenous vitamin C to reduce fatigue influenced investigators to conduct this experiment.
The purpose of the study was to determine the efficacy of an intravenous dose of vitamin C on fatigue in healthy office workers. The independent variable was a high dose of vitamin C (10g) injection, and the dependent variable was fatigue in healthy workers. Researchers …show more content…
The age variation may also cause impact on the individual’s fatigue status and the baseline levels of plasma vitamin C concentrations. Study participants were recruited from two different companies without randomization so; the lack of randomization negatively affected the outcome of the experiment to the target population. The principle investigators suggested that varying results of previous studies might be due to the different route of dosing or disregarding the baseline vitamin C levels. Principle investigators did find that vitamin C is very effective in subjects with low baseline levels of vitamin C and the effect lasted for 24 hours after dosing. Further studies are required to determine the effective dose ranges of vitamin C as a treatment for the fatigue and the frequency of intravenous dosing to enhance the therapeutic effect of vitamin C. Patients with severe fatigue and patients at risk for vitamin C deficiency would better elaborate the potential clinical implications of intravenous dosing of vitamin C on

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