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Fish Accurate Toxicity

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The EPA uses the fish acute toxicity to determine the lethal concentration of a toxin but there is a growing demand for alternative testes. The reason for this is the possibility for finding a test that can lower the cost of materials and labor. There has also been an increasing concern for decreasing the number of animals used for research. While there are different methods that can replace the fish acute toxicity there are none that have been widely accepted by governmental agencies. Alternative methods can be replaced by computational methods and by vitro cell-based techniques. Accurate estimations of lethal concentrations can be determined by using computer programs, such as using (Q)SARs with data provided by previous research. Using computer

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