...Binding Between Ocular Lens Crystallins Linked to Cataract Formation Abstract As biological resistance against cataracts, proteins called α-crystallins in the lens of the eye are present to keep denatured crystallins from precipitating and forming cataracts. Over time, these α-crystallins are increasingly bound to denatured proteins and contribute to the conglomeration of other crystallins themselves. Since the eye does not replace these essential proteins, the incidence of cataract formation increases without α-crystallin binding. Biochemists at the University of California-Irvine have recently observed trends in αB-crystallins’ interaction with structural γS-crystallin variations, which established a connection between cataract formation and the absence of the αB-crystallin. Molecular discoveries regarding αB-crystallin and γS-crystallin structures have also introduced the possibility of developing protein-specific drugs and corrective treatment for cataracts, as well as providing more widely available options for lower-income global populations. Introduction Cataracts are becoming increasingly prevalent in the aging world population. A study published in 2010 by the World Health Organization quoted the occurrence of visual impairment worldwide at 285 million; of these, 33% of avoidable visual impairment cases and 51% of avoidable blindness cases are caused solely by cataracts (Visual Impairment and Blindness 2010, S.P. Mariotti et al.). As defined by the American Optometric...
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...The Need for Strategic Agility: How to introduce strategic renewal and rebuild corporate strategies Copenhagen Conference on Strategic Management 2007 Copenhagen Business School, Denmark, December 11-12, 2007 The Timken Chaired Professor of Global Technology and Innovation Visiting Professor, Helsinki School of Economics/CKIR © Yves Doz, Mikko Kosonen, 2007 Professor Yves Doz INSEAD Sources of Sustained Growth and High Performance • Clear Focus • We should have a clear vision for the future of our core business • We should have a sustained effort at maximally leveraging our core business • We should have a tight focus on continuous improvement • We should have a leadership position in everything we do • High Efficiency • We should have strong business units with sufficient autonomy as they grow • We should have highly efficient business systems and processes • We should have deep collaborative relationships with our key customers and partners • Quick Commitment • We should have clear charters for all organizational units • We should have strong and experienced leaders with proven track record © Yves Doz, Mikko Kosonen, 2007 Single-minded attention to ‘clear direction and focus leads to… Driver •Clear vision for the future of our core business •Sustained effort at maximally leveraging our core business •Tight focus on continuous improvement •Leadership position in everything we do •High action orientation and self-confidence Consequence •Considering everything...
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...In this session of class we went discuss abortions and ways to get pregnant. I was feeling really uncomfortable at first since it is essential a social taboo to even speak about abortion especially since I grew up in a christian household. I was taught and still believe in not getting an abortion. Once I saw the facts and was a clinical abortion was changed how I looked at. For example, I had this assumation that the egg had developed to the point where we can distinguish them with other human but once I saw a picture of what a normal looked like. I was completely baffled when I saw it was less than the size of a dime. Another point that really stood out to me is the fact the federal act can only stop federal and state abortion clinic which only prevents safe abortions. With this in mind I changed my views to more of a pro choice for those This helped a lot since the only information I generally obtained about abortion are from the radicals who show up on campus from time to time with the graphic images of abortion. Further on in the class we begin talking about artificial insemination. This was an interesting topic to me since I been explained the full procedure or operations such as in vitro infertilization it was interesting to see the possibilities that couple who suffer from infertility.Also the other potions that people have who want a baby can have such as a suggate mother and adoption. I was familiar with adoption and everything we talk about ...
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...September 10, 2013 Charles Bocage, MBA, MSIS, TQM Job Description and Recruiting Strategies When employers create job descriptions it increases the chances of hiring the right person for a specific job. Job descriptions provide employees with a clear definition of job duties along with the expectations for both the employer and the employee. Well-written job descriptions direct employees for success. The job description also provides a good starting point for staff performance reviews. By wording a job description correctly the business can ensure it is within legal compliance. A job description contains a list of the tasks, duties, responsibilities, reporting relationships associated with the job (“Job Descriptions to Job Fluidity: Treading the Dejobbing Path,” 2007). Job descriptions are drafted statements indicating the minimal acceptable qualifications incumbents must possess to successfully perform the essential elements of their jobs (DeCenzo & Robbins, 2007). Job Description of Receptionist The receptionist’s essential duties and responsibilities consist of greeting and directing vendors, customers, job applicants, and other visitors via the phone or in person. The receptionist must answer, screen, and route incoming calls; taking messages when the caller does not want voice mail. He or she notifies employees when customers and visitors arrive. Another duty is to assist job applicants who have arrived for interviews. The receptionist will be able...
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...This poem belongs to the “Confessional School of poets”. These poets believed that as a result of the post world war genocide, atom bombs and concentration camps, human psyche has been damaged to a large extent, leaving the poets with the responsibility to explore their own recesses of darkness. Margaret Atwood was deeply influenced by this urge to embark upon such an inner and imaginative journey. The poem “Journey To The Interior” portrays Atwood’s attitude on inner journey to discover oneself. She presents a metaphorical journey to explain a journey into the mind. She examines human behavior’s reasons, understanding one self’s mystery, lack of knowledge of individuals about themselves. Atwood has composed a metaphysical journey contrasting the similarities and differences. Her fascination with the bizarre fluidity of identity and its mystery is the focus of thy poem. The first paragraph establishes the similarities between physical and metaphysical journey. The usage of the personal pronoun ‘I’ in this introductory paragraph establishes the personal experience of the poet as it is her who undertakes the physical journey in the poem’s case an awful; bush walk. The poem starts off with a factual matter of fact in bush. The pairing knife and white mushrooms suggest the distraction that little experiences can cause and sidetrack the undertaker from their journey to the interior. The usage of parenthesis with the rhetorical questions (have I been walking in circles...
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...disenfranchised and powerless amidst the easily perceived promising future of equality. In the following response, I will argue the integration of humanist ethical ideologies that illicitly and surreptitiously generate racist ideologies that subjugate the colonized non-Western “other”. Social Darwinism, eugenics, imperialism, nationalism, cultural relativity, and multiculturalism are the main ideas that support my argument which will be subsequently elaborated on. For centuries, the doctrine of white male hegemonic enslavement has dominated, degraded, and dehumanized the disenfranchised and powerless from the privileged. The beliefs, values, culture, and ideology that all these different number of systems of thinking would create the knowledge of humanitarian effort to intervene in trying to justify and clarify racism without question. Universalism helped to fuel the binary opposition of the colonizers versus the colonized. The binary system is far from valiantly subverting stereotypes, such manufactured ideologies are deeply invested in upholding stereotypes, which in turn generates the idea of “difference” and this difference plays a role in sustaining racism. In other words, if words like “progressive” and “civilized” are tied to the group “colonizers” then in the negative antonyms of those words like “traditional” and “backwards” will be tied to the group “colonized”. This method of categorizing is innately a human construct. As a result, the majority (colonized and/or “non-Western...
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...Microeconomics and the Laws of Supply and Demand Terry Cerami ECO/365 September 21, 2015 David Flesh Microeconomics and the Laws of Supply and Demand Utilizing the supply and demand simulation ("University Of Phoenix", 2014), I will illustrate two macroeconomic and two microeconomic principles demonstrated in the simulation and expound on why these principles are categorized as microeconomic or macroeconomic. Also, one shift of the demand curve and one shift of the supply curve from the simulation will be identified with explanations for the shifts. Further, I will analyze the influence on decision making in correlation with quantity and the equilibrium of price and how these concepts of demand and supply can be pragmatic in everyday business or within the current work environment. Finally, I will explain how price elasticity of demand has an immense impact on products pricing strategy and its purchase from the consumer. Macroeconomic and Microeconomic Principles The first macroeconomic principle demonstrated within the Supply and demand Simulation is Price Ceilings. Price Ceilings ensue through legislation as laws are enacted establishing a lawful ceiling of how high the cost of a product can be ("Price Ceilings", n.d.). When a price ceiling is established, there is further demand than what is available at the equilibrium price. This is a result of there being a sufficient supply in quantity of demand than supplied quantity. For example, in the simulation the...
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...station demands much more from a railway concourse. The National Rail has chalked out the key requirements for every station with Security, Information, Navigation and Facilities as one of the few Basic needs followed by Higher-level needs such as Retail and Catering. In the life of all cities, the railway station plays an important role in the day-to-day life of its citizens and thereby a constant effort has been made to keep up with increasing requirements of the concourse yet maintaining the fluidity of spaces. This report discusses the effect of a concourse layout and its relation with the urban context on the process of ‘navigation’ and ‘way finding’ in the system. Another aspect of railways stations is the way it fits into the urban system which determines the nature of the concourse and the way people interact with the space. Liverpool street station gives an impression of it being an enclosed public square, accompanied by way finding as an easy process and thereby the fluidity of space is maintained. A contrasting observation is made at Victoria station, where many visits can yet sustain an unfamiliar environment. A comparative between Liverpool street station and Victoria station in this area of study and understanding the integration of the concourses of stations into the urban...
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...Discussion at Alumni Symposia- 2013 References ● Wikinomics: How Mass Collaboration Changes Everything (ISBN 1591841380) Don Tapscott and Anthony D. Williams Mckinsey Quarterly Sloan Review Mint Blogs ● ● ● ● ● GigaOm Wired Techcrunch Wall Street Journal Ross Dawson ● ● ● ● ● Many others So What is the the Future of Human Resource And this is just the good news ! Why ? Technology & Outsourcing will replace transactional work Individualism will trash most HR Policies – especially in Hi-tech and then other sectors Collaboration tools will make real engagement possible and not just a Gallup Score – which has presence & meaning more in corporate presentations and resumes than real life Fluidity & Change will replace most Stable HR Constructs and Premises- Organisation Structure/ Design , Compensation, Jobs, Value chains Why ? Technology & Outsourcing will replace transactional work 2006- Unilever outsourced- HR operations, payroll, resourcing and even some of the learning services to Accenture . As Unilever said “The outsourcing programme is part of the company’s One Unilever initiatives to increase leverage of its scale, improve its marketplace competitiveness, deliver functional excellence, and create a more competitive cost-structure allowing it to focus on its consumers and customers.” p.s.- got renewed in Dec 2012 Intelligent programmes – will scavenge every social media site and come out with a report on how your...
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...Michael Huemer is a professor at the University of Colorado. He studies ethics and theory of knowledge while teaching philosophy at the university. His work with ethical intuitionism, moral realism, anarcho-capitalism, and libertarianism shaped many discussions Huemer has fore fronted, and brings us to “Three Skeptical Arguments,” an excerpt from Skepticism and the Veil of Perception. The debate question Huemer touches on is “can humans truly know anything?” He takes the negative position, stating that no human can or will ever truly possess knowledge. He breaks his main theory into an argument, which is then separated into three sections that he uses to support his disputation: ‘the infinite regress argument,’ ‘the problem of criterion,’...
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...An Occurrence at Owl Creek Bridge Ambrose Bierce A man and his executioners stand on a railroad bridge in Alabama. The Civil War has begun and military justice is about to be served; the only spectators are a handful of soldiers. The man to be executed is a civilian dressed in the clothes of a plantation owner, and his executioners are Union soldiers. As he waits for his executioners to start, the man looks down at the water below him and imagines ways he could escape home to his wife and children. With a nod of the captain's head, the hanging begins. Part 2 introduces Peyton Farquhar, a wealthy Alabamian slave owner. Farquhar is not in the army because of personality issues, but he is determined to support the Confederate cause. An opportunity appears when a soldier dressed in a gray Confederate uniform rides up to his house. The soldier tells him that Union troops are repairing railroads in the surrounding area and have recently rebuilt the nearby bridge over Owl Creek. Apparently the chief has issued an order saying that any civilian caught tampering with the railroad will be hanged. The soldier leaves after informing Farquhar that a pile of flammable timber was piled up near the bridge. An hour later, the soldier rides past the Farquhar residence heading north. It turns out that he is actually a Union scout. Part 3 begins with Farquhar falling through the bridge. Unable to think wisely, he feels himself freeing his hands from their bindings, removing the noose around...
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...Journal 6 Trauma and Memory Brain in a Search for the Living Past written by Peter Levine is a fascinating book that explains the fluidity of memories combined with the different ways in which they are stored. I enjoy that it is well written incorporating science in an easy to read manner. He highlights the reconstructive process stating that it is continuously adding, deleting, rearranging, and updating information. Understanding that memory is not concrete is extremely important to a counselor. Comprehending that our mood at the time of the event effects how the memory is stored increases our understanding of our clients when they relay details of the past. Helpful memories are ones we learn from and move on. Ordinary memories change over time. Traumatic memories are static. Realizing that there are explicit (conscious) and implicit (unconscious) memories were valuable because we must remember that the body knows what happened even if the client cannot remember the event consciously. This will help us to understand why a client may be reacting abnormally to certain situations. It allows us to hypothesis are they reacting to smells, touch, visual or sounds. We can then ask the client questions that may assist them to clarify. When you feel anxiety what do you notice? Is there a smell? What does the environment look like? Is there...
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...Assignment#2 SOCI 1301 July 25th , 2000 Micro level theories aimed at understanding social life at the intimate level of individuals and their interactions. The micro sociological approach places emphasis on face-to-face social interaction, or what people do when they are in the presence of one another. Roles are sets of expectations, rights, and duties that are associated with a given status. The dramaturgical analysis provided by Erving Goffman analyzes everyday life in terms of the stage. Socialization prepares people for learning to perform on the stage of everyday life. Core of this approach is the analysis of the impressions we attempt to make on others by using sign-vehicles like setting, appearance, and manner, teamwork, and face-saving behavior. Human actions are dependent on time, place, and audience and the favorable presentation of self by an individual via the use of impression management. An example for this is even if a couple is not in terms; they still act intimate and conceal their anger in the presence of others in order to save face. In a structural functionalist perspective, the family system regulates sexual activity, provides socialization processes, and transmits culture and the members of the family act their roles as father, mother and child. In dramaturgical analysis humans are like actors on a stage in which there are roles (scripts) and statuses (parts of the play) to carry out. Defining the social situation states that the perception of reality...
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...human behaviour in a social context. Sociologists focus upon relationships between society and what we can describe as thought and action, or understanding and behavior as well as their contributing social factors in order to enhance our understanding of individual human experience and to consequently improve society (Furze et al, 2015). In reflection of my sociology studies this semester, the key concept that highlights what I’ve learned and how the knowledge gained as a result has impacted my personal experiences is the “Sociological Imagination”. The Sociological Imagination is a unique way of thinking that allows individuals to see the interrelation between private troubles...
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...Using your own knowledge as well as the extract identify and explain two sources of the British constitution (10) A constitution is a framework of rules that dictate the way a country is run, it defines the relationship between the state and individual and also the way in which power is divided between the various parts of the state, for example between the house of commons, the house of Lords and parliament. There are different types of constitutions, the most basic way of dividing constitutions is placing them into two groups; codified (written in one single document) for example in the USA and uncodified (unwritten, no single, formal document) in the UK. One source of the British constitution is statute law, this is law that is written down and codified into law. Statutes begin as bills: there are public and private bills. Public Acts are those that affect either the whole of the UK or some of its constituent countries; England, Scotland, Wales and Northern Ireland, whereas private Acts may grant limited powers to public bodies such as local authorities (councils), or apply only to specific locations within the UK. To begin with, a bill is scrutinised and then refined if needed before the final draft is created. Then it is given its first reading, and after its second reading there is a general debate as to its contents. Once at the ‘Committee stage’ both the House of Commons and the House of Lords may make amendments to it. Then further amendments may be made when it...
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