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Genetically Modified Animals

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Genetically Modified and Engineered Animals
Heather Swanson
Introduction to Biology
Professor Jiru
March 15, 2015

A genetically modified animal is one that has had its DNA altered, by either changing or removing certain DNA sequences in a way that does not occur naturally. The reason they do this is to modify the characteristics of an animal or introduce new traits, such as enhanced growth or disease resistance. Changes to the animals genetic make up, DNA, can then be transmitted to the next generation. Genetically modified animals are being produced for two main reasons, human medicine and agriculture. Genetic modifying is a useful technology because it enables animals to produce useful proteins. Conventional animal breeding is restrained to naturally occurring variations in the proteins that are present in a certain species. This limits the range and extent of genetic improvement that can be achieved.
Most animal research is in the field of human medicine. Many therapeutic proteins for the treatment of human disease require animal cell specific modifications to be effective, currently most are produced in mammal cell based reactors. The manufacturing capacity for therapeutic proteins can’t keep pace with the rapid progress in drug discovery and development, this has resulted in rising costs and unmet needs. Genetically modified animals may provide an important source of these protein drugs in the future because the production of recombinant (DNA formed by laboratory methods) proteins in milk, blood or eggs of modified animals presents a less expensive approach to producing therapeutic proteins in animal cells.
Genetically modified animals are also being used to produce serum products such as antibodies that can be used for treatment of infections, cancer, organ transplant rejections and autoimmune diseases. The current production system for

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